Research Articles

2017 Research Articles

September

2015 Research Articles

December
November
September
Neonatal anesthesia: how we manage our most vulnerable patients
Korean J Anesthesiol. 2015 Oct; 68(5): 434–441.
Published online 2015 Sep 30.

 

 

August
Efficacy of rutin in inhibiting neuronal apoptosis and cognitive disturbances in sevoflurane or propofol exposed neonatal mice
Int J Clin Exp Med. 2015; 8(8): 14397–14409.
Published online 2015 Aug 15.

 

 

Pediatric dental sedation: challenges and opportunities
Clin Cosmet Investig Dent. 2015; 7: 97–106.
Published online 2015 Aug 26.

 

July
Long-Term Behavioral Effects in a Rat Model of Prolonged Postnatal Morphine Exposure
Behavioral Neuroscience, Vol 129(5),
Craig, M. M., & Bajic, D. (2015, July 27).

 

 

Long-term action of propofol on cognitive function and hippocampal neuroapoptosis in neonatal rats
Int J Clin Exp Med. 2015; 8(7): 10696–10704.
Published online 2015 Jul 15.

Neuroprotective properties of vitamin C on equipotent anesthetic concentrations of desflurane, isoflurane, or sevoflurane in high fat diet fed neonatal mice
Int J Clin Exp Med. 2015; 8(7): 10444–10458.
Published online 2015 Jul 15.

Anesthetic use in newborn infants: the urgent need for rigorous evaluation
Pediatr Res. 2015 Jul; 78(1): 2–6.
Published online 2015 Apr 8.

Cognition and Brain Structure Following Early Childhood Surgery With Anesthesia
Pediatrics, June 2015
Barynia Backeljauw, Scott K. Holland, Mekibib Altaye, Andreas W. Loepke

Propofol: A Review of its Role in Pediatric Anesthesia and Sedation
CNS Drugs, July 2015, Volume 29, Issue 7, pp 543-563

Age-dependent electroencephalogram (EEG) patterns during sevoflurane general anesthesia in infants
eLIFE, July 2015

Age-dependency of sevoflurane-induced electroencephalogram dynamics in children
British Journal of Anaesthesia, 2015

June
Cognition and Brain Structure Following Early Childhood Surgery With Anesthesia
Pediatrics, June 2015
Backeljawu B, Holland SK, Altaye M, Loepke AW

 

 

microRNA Expression Profiling of Propofol-Treated Developing Rat Hippocampal
DNA Cell Biol, June 2015.
Sun W, Pei L

Regional (spinal, epidural, caudal) versus general anaesthesia in preterm infants undergoing inguinal herniorrhaphy in early infancy
Cochrane Database Syst Rev., June 2015.
Jones LJ, Craven PD, Lakkundi A, Foster JP, Badawi N

Ketamine-Induced Toxicity in Neurons Differentiated from Neural Stem Cells
Mol Neurobiol, June 2015.
Slikker W Jr, Liu F, Rainosek SW, Patterson TA, Sadovova N, Hanig JP, Paule MG, Wang C

Early Exposure to General Anesthesia Disrupts Spatial Organization of Presynaptic Vesicles in Nerve Terminals of the Developing Rat Subiculum
Mol Neurobiol, June 2015.
Lunardi N, Oklopcic A, Prillaman M, Erisir A, Jevtovic-Todorovic V.

Long-term NMDA receptor inhibition affects NMDA receptor expression and alters glutamatergic activity in developing rat hippocampal neurons
Toxicology, June 2015. 
Sinner B, Friedrich O, Lindner R, Bundscherer A, Graf BM 

Anesthesia-related critical incidents in the perioperative period in children; a proposal for an anesthesia-related reporting system for critical incidents in children
Paediatr Anaesth, June 2015.
De Graaff JC, Sarfo MC, van Wolfswinkel L, van der Werff DB, Schouten AN

Safe Anesthesia For Every Tot – The SAFETOTS initiative.
Curr Opin Anaesthesiol, June 2015. Weiss M, Vutskits L, Hansen TG, Engelhardt T

Surgical Anesthesia in Young Children Linked to Effects on IQ, Brain Structure
Cincinnati Surgical, June 08, 2015

May
Carbon monoxide modulates Cytochrome Oxidase Activity and Oxidative Stress in the Developing Murine Brain During Isoflurane Exposure
Free Radic Biol Med.
2015 May 29. pii: S0891-5849(15)00252-X. doi: 10.1016/j.freeradbiomed.2015.05.029. [Epub ahead of print] Cheng Y1, Mitchell-Flack MJ2, Wang A<2, Levy RJ

 

 

Apnea after Awake Regional and General Anesthesia in Infants: The General Anesthesia Compared to Spinal Anesthesia Study-Comparing Apnea and Neurodevelopmental Outcomes, A Randomized Controlled Trial
Anesthesiology,
May 2015.  Davidson AJ, Morton NS, Arnup SJ, de Graaff JC, Disma N, Withington DE, Frawley G, Hunt RW, Hardy P, Khotcholava M, von Ungern Sternberg BS, Wilton N, Tuo P, Salvo I, Ormond G, Stargatt R, Locatelli BG, McCann ME

Predictors of Failure of Awake Regional Anesthesia for Neonatal Hernia Repair: Data from the General Anesthesia Compared to Spinal Anesthesia Study-Comparing Apnea and Neurodevelopmental Outcomes. Anesthesiology. 2015 May 14. Frawley G1, Bell G, Disma N, Withington DE, de Graaff JC, Morton NS, McCann ME, Arnup SJ, Bagshaw O, Wolfler A, Bellinger D, Davidson AJ; General Anesthesia compared to Spinal anesthesia (GAS) Consortium.


Is this your (paediatric patient’s) brain on (anaesthetic) drugs?: The search for a potential neurological phenotype of anaesthesia-related neurotoxicity in humans

European Journal of Anaesthesiology, May 2015.  Loepke AW, Hansen TG.<

Risk of autistic disorder after exposure to general anaesthesia and surgery: A nationwide, retrospective matched cohort study
European Journal of Anaesthesiology, May 2015. Ko WR, Huang JY, Chiang YC, Nfor ON, Ko PC, Jan SR, Lung CC, Chang HC, Lin LY, Liaw YP

Anesthesia and the developing brain: a way forward for clinical research.
Paediatr Anaesth, May 2015. Davidson AJ, Becke K, de Graff J, Giribaldi G, Habre W, Hansen T, Hunt RW, Ing C, Loepke A, McCann ME, Ormond GD, Pini Prato A, Salvo I, Sun L, Vutskits L, Walker S, Disma N.

Impact of propofol anaesthesia on cytokine expression profiles in the developing rat brain: A randomised placebo-controlled experimental in-vivo study
Eur J Anaesthesiol, May 2015. Kargaran P, Lenglet S, Montecucco F, Mach F, Copin JC, Vutskits L

Regional anaesthesia in neonates, infants and children: An educational review
European Journal of Anaesthesiology, May 2015. Martin J

Elevation of Sestrin-2 expression attenuates Sevoflurane induced neurotoxicity
Metab Brain Dis, May 2015. Yi W, Zhang Y, Guo Y, Li D, Li X

April
Only extra-high dose of ketamine affects l-glutamate-induced intracellular Ca2+ elevation and neurotoxicity Neurosci Res, April 2015.  Shibuta S, Morita T, Kosaka J, Kamibavashi T, Funino Y

 

 

Dexmedetomidine Attenuates Neurotoxicity Induced by Prenatal Propofol Exposure.
J Neurosurg Anesthesiol, April 2015.
Li J, Xiong M, Nadavaluru PR, Zuo W, Ye JH, Eloy JD, Bekker A.

Repeated Exposure to Ketamine-Xylazine during Early Development Impairs Motor Learning-dependent Dendritic Spine Plasticity in Adulthood
Anesthesiology, April 2015.  Huang L, Yang G

Neurodevelopmental implications of the general anesthesia in neonate and infants
Exp Neurol, April 2015.
Lee JH, Zhang J, Wei L, Yu SP

Neurotoxicity of Generic Anesthesia Agents in Infants and Children: An Orphan Research Question in Search of a Sponsor
JAMA, April 2015. Psaty BM, Platt R, Altman RB

Low-dose sevoflurane promotes hippocampal neurogenesis and facilitates the development of dentate gyrus-dependent learning in neonatal rats.
ASN Neuro. April 2015. Chen C, Shen FY, Zhao X, Zhou T, Xu DJ, Wang ZR, Wang YW

Perioperative effects of caudal and transversus abdominis plane (TAP) blocks for children undergoing urologic robot-assisted laparoscopic surgery.
J Pediatr Urol, April 2015. Faasse MA, Lindgren BW, Frainey BT, Marcus CR, Szczodry DM, Glaser AP, Suresh S, Gong EM

Developmental stage-dependent impact of midazolam on calbindin, calretinin and parvalbumin expression in the immature rat medial prefrontal cortex during the brain growth spurt.

Int J Dev Neurosci, April 2015. Osterop SF, Virtanen MA, Loepke JR, Joseph B, Loepke AW, Vutskits L

Surgical Injury in the Neonatal Rat Alters the Adult Pattern of Descending Modulation from the Rostroventral Medulla
Anesthesiology. 2015 Apr 13. Walker SM, Fitzgerald M, Hathway GJ

Neurosurgical conditions and procedures in infancy are associated with mortality and academic performances in adolescence: a nationwide cohort study
Paediatr Anaesth, February 2015. Hansen TG, Pedersen JK, Henneberg SW, Morton NS, Christensen K

2013 Research Articles

November
A systematic review and quantitative analysis of neurocognitive outcomes in children with four chronic illnesses.
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, Calgary, AB, Canada., November 2013.

October
September
August
Anesthetic neurotoxicity in the newborn and infant
Department of Anesthesiology and Perioperative Medicine Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Portland, OR, August 29, 2013.

July
Safety first, safety at early age: The quagmire of neurotoxicity in pediatric anaesthesia
Indian Journal of Anaesthesia, July 25, 2013.

Ketamine as Anesthetics can Damage Children’s Learning and Memory Ability
Science Codex, July 19, 2013.

Long-term effects of neonatal single or multiple isoflurane exposures on spatial memory in rats.
Department of Experimental Psychology, University of Oxford, Oxford , UK ; Glickenhaus Laboratory of Neuropsychology, Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai , New York, NY , USA., July 2013.

June
Cell age-specific vulnerability of neurons to anesthetic toxicity
Department of Anesthesiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH; Program in Neuroscience, University of Cincinnati, Cincinnati, OH, June 2013.
March
Neonatal Sevoflurane Anesthesia Induces Long-Term Memory Impairment and Decreases Hippocampal PSD-95 Expression without Neuronal Loss
Anesthesiology, March 2013. Department of Anesthesia, ZhongShan hospital, Fudan University, Shanghai, China

2011 Research Articles

December
The abolishment of anesthesia-induced cognitive impairment by timely protection of mitochondria in the developing rat brain: The importance of free oxygen radicals and mitochondrial integrity
Neurobiology of Disease. 2011 Dec 14. [Epub ahead of print] Boscolo A, Starr JA, Sanchez V, Lunardi N, Digruccio MR, Ori C, Erisir A, Trimmer P, Bennett J, Jevtovic-Todorovic V.

Protective Function of Nicotinamide Against Ketamine-induced Apoptotic Neurodegeneration in the Infant Rat Brain
Journal of Molecular Neuroscience. 2011 Dec 8. [Epub ahead of print] Ullah N, Ullah I, Lee HY, Naseer MI, Seok PM, Ahmed J, Kim MO.

October
Anesthetics and Sedatives: Toxic or Protective for the Developing Brain?
Pharmacological Research [Epub ahead of print] Ward CG, Loepke AW

Cognitive and Behavioral Outcomes After Early Exposure to Anesthesia and Surgery
Pediatrics. [Epub adhead of print] Flick RP, Katusic SK, Colligan RC, Wilder RT, Voigt RG, Olson MD, Sprung J, Weaver AL, Schroeder DR, Warner DO

September
Anesthetic-Related Neurotoxicity and the Developing Brain: Shall We Change Practice?
Paediatric Drugs [Epub ahead of print] Vutskits L

Neurotoxicity of Anesthetic Drugs in the Developing Brain
Anesthesia & Analgesia [Epub ahead of print] Stratmann G

Neonatal Desflurane Exposure Induces More Robust Neuroapoptosis than Do Isoflurane and Sevoflurane and Impairs Working Memory
Anesthesiology [Epub ahead of print] Kodama M, Satoh Y, Otsubo Y, Araki Y, Yonamine R, Masui K, Kazama T

GABAergic Excitotoxicity Injury of the Immature Hippocampal Pyramidal Neurons’ Exposure to Isoflurane Anesthesia & Analgesia [Epub ahead of print] Zhao YL, Xiang Q, Shi QY, Li SY, Tan L, Wang JT, Jin XG, Luo AL

General Anesthesia Causes Long-term Impairment of Mitochondrial Morphogenesis and Synaptic Transmission in Developing Rat Brain
Anesthesiology [Epub ahead of print] Sanchez V, Feinstein SD, Lunardi N, Joksovic PM, Boscolo A, Todorovic SM, Jevtovic-Todorovic V

August
Anesthesia and the developing brain: are we getting closer to understanding the truth?
Current Opinion in Anesthesiology Jevtovic-Todorovic V

Developmental Stage-dependent persistent impact of propofol anesthesia on dendritic spines in the rat medial prefrontal cortex
Anesthesiology Briner A, Nikonenko I, De Roo M, Dayer A, Muller D, Vutskits L

Propofol induces neuronal apoptosis in infant rat brain under hypoxic conditions
Brain Research Bulletin Tu S, Wang X, Yang F, Chen B, Wu S, He W, Yuan X, Zhang H, Chen P, Wei G

July
Are anaesthetics toxic to the brain?
British Journal of Anaesthesia Hudson AE, Hemmings HC Jr

Disruption of blastomeric F-actin: a potential early biomarker of developmental toxicity in zebrafish Molecular and Cellular Biochemistry Kanungo J, Paule MG

May
Academic Performance in Adolescence after Inguinal Hernia Repair in Infancy: A Nationwide Cohort Study Anesthesiology Hansen TG, Pedersen JK, Henneberg SW, Pedersen DA, Murray JC, Morton NS, Christensen K

FDA considers data on potential risks of anesthesia use in infants, children
The Journal of the American Medical Association Kuehn BM

April
Defining safe use of anesthesia in children
The New England Journal of Medicine Rappaport B, Mellon RD, Simone A, Woodcock J

Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeys Neurotoxicology and Teratology Paule MG, Li M et al.

2016 Research Articles

2014 Research Articles

October
Anesthesia in Children: Perspectives From Nonsurgical Pediatric Specialists
Journal of Neurosurgical Anesthesiology, October 2014.

Clinical Research Into Anesthetic Neurotoxicity: Does Anesthesia Cause Neurological Abnormalities in Humans?
Journal of Neurosurgical Anesthesiology, October 2014.

Engaging Stakeholders in Research Related to Anesthesia and Neurodevelopment in Children
Journal of Neurosurgical Anesthesiology, October 2014.

Isoflurane Impairs the Capacity of Astrocytes to Support Neuronal Development in a Mouse Dissociated Coculture Model
Journal of Neurosurgical Anesthesiology, October 2014.

Ketamine Affects the Neurogenesis of Rat Fetal Neural Stem Progenitor Cells via the PI3K/Akt-p27 Signaling Pathway.
Birth defects research. Part B, Developmental and reproductive toxicology, October 2014.

Neurodevelopmental Outcomes After Initial Childhood Anesthetic Exposure Between Ages 3 and 10 Years Journal of Neurosurgical Anesthesiology, October 2014.

Pediatric Surgeons and Anesthesiologists Expand the Dialogue on the Neurotoxicity Question, Rationale for Early and Delayed Surgeries, and Practice Changes While Awaiting Definitive Evidence
Journal of Neurosurgical Anesthesiology, October 2014.

Postoperative Cognitive Function Following General Versus Regional Anesthesia: A Systematic Review Journal of Neurosurgical Anesthesiology, October 2014.

Report of the Fourth PANDA Symposium on Anesthesia and Neurodevelopment in Children Journal of Neurosurgical Anesthesiology, October 2014.

Review: effects of anesthetics on brain circuit formation.
Journal of Neurosurgical Anesthesiology, October 2014.

2012 Research Articles

December
Perioperative Central Nervous System Injury in Neonates
British Journal of Anaesthesia. 2012 Dec;109 Suppl 1. McCann ME, Soriano SG.

Early Developmental Exposure to Volatile Anesthetics Causes Behavioral Defects in Caenorhabditis elegans Anesth Analg. 2012 Dec 7. [Epub ahead of print] Gentry KR, Steele LM, Sedensky MM, Morgan PG.

November
Newly Postulated Neurodevelopmental Risks of Pediatric Anesthesia: Theories That Could Rock Our World The Journal of Urology. J Urol. 2012 Nov 20. [Epub ahead of print] Hays SR, Deshpande JK.
October
Preclinical research into the effects of anesthetics on the developing brain: promises and pitfalls
J Neurosurg Anesthesiol. 2012 Oct;24(4):362-7. Mintz CD, Wagner M, Loepke AW.

Anesthetics interfere with the polarization of developing cortical neurons
J Neurosurg Anesthesiol. 2012 Oct;24(4):368-75. Mintz CD, Smith SC, Barrett KM, Benson DL.

Isoflurane-induced apoptosis of oligodendrocytes in the neonatal primate brain
Ann Neurol. 2012 Oct;72(4):525-35. Brambrink AM, Back SA, Riddle A, Gong X, Moravec MD, Dissen GA, Creeley CE, Dikranian KT, Olney JW.

Report of the third PANDA symposium on “Anesthesia and Neurodevelopment in Children”
J Neurosurg Anesthesiol. 2012 Oct;24(4):357-61. Miller TL, Park R, Sun LS.

Feasibility and pilot study of the Pediatric Anesthesia NeuroDevelopment Assessment (PANDA) project
J Neurosurg Anesthesiol. 2012 Oct;24(4):382-8. Sun LS, Li G, DiMaggio CJ, Byrne MW, Ing C, Miller TL, Bellinger DC, Han S, McGowan FX.

Elective procedures and anesthesia in children: pediatric surgeons enter the dialogue on neurotoxicity questions, surgical options, and parental concerns
J Neurosurg Anesthesiol. 2012 Oct;24(4):396-400. Byrne MW, Ascherman JA, Casale P, Cowles RA, Gallin PF, Maxwell LG.

Pediatric anesthesia and neurodevelopmental impairments: a Bayesian meta-analysis
J Neurosurg Anesthesiol. 2012 Oct;24(4):376-81. DiMaggio C, Sun LS, Ing C, Li G.

Anesthesia-Induced Developmental Neurodegeneration: The Role of Neuronal Organelles
Front Neurol. 2012; 3: 141. Published online 2012 October 11. doi: 10.3389/fneur.2012.00141 Vesna Jevtovic-Todorovic, A. Boscolo, V. Sanchez, N. Lunardi

Advanced pre-clinical research approaches and models to studying pediatric anesthetic neurotoxicity
Front Neurol. 2012;3:142. doi: 10.3389/fneur.2012.00142. Epub 2012 Oct 17. Wang C.

SmartTots: A Public-Private Partnership Between the United States Food and Drug Administration (FDA) and the International Anesthesia Research Society (IARS)
Paediatr Anaesth. 2012 Oct;22(10):969-72. Ramsay JG, Roizen M, Davidson A

September
Propofol at Clinically Relevant Concentrations Increases Neuronal Differentiation But Is Not Toxic to Hippocampal Neural Precursor Cells In Vitro
Anesthesiology. 2012 Sep 20. [Epub ahead of print] Sall JW, Stratmann G, Leong J, Woodward E, Bickler PE

Neonatal Exposure to Sevoflurane Causes Apoptosis and Reduces nNOS Protein Expression in Rat Hippocampus
Mol Med Report. 2012 Sep;6(3):543-6. doi: 10.3892/mmr.2012.976. Epub 2012 Jul 2. Zhou X, Song FH, He W, Yang XY, Zhou ZB, Feng X, Zhou LH.

Are Anesthesia and Surgery during Infancy Associated with Altered Academic Performance during Childhood?
Anesthesiology. 2012 Sep;117(3):494-503. Block RI, Thomas JJ, Bayman EO, Choi JY, Kimble KK, Todd MM.

Long-term Differences in Language and Cognitive Function After Childhood Exposure to Anesthesia Pediatrics. 2012 Sep;130(3):e476-85. Ing C, Dimaggio C, Whitehouse A, Hegarty MK, Brady J, von Ungern-Sternberg BS, Davidson A, Wood AJ, Li G, Sun LS.

Review Article: Neuraxial Analgesia in Neonates and Infants: A Review of Clinical and Preclinical Strategies for the Development of Safety and Efficacy Data
Anesthesia & Analgesia. 2012 Sep;115(3):638-62. Epub 2012 Jul 13. Walker SM, Yaksh TL.

August
General Anesthesia: A Gateway to Modulate Synapse Formation and Neural Plasticity?
Vutskits L Anesthesia & Analgesia. 2012 Aug 2. [Epub ahead of print]
February
Attention-deficit/hyperactivity disorder after early exposure to procedures requiring general anesthesia Mayo Clinic Proceedings. 2012 Feb;87(2):120-9. Sprung J, Flick RP, Katusic SK, Colligan RC, Barbaresi WJ, Bojanić K, Welch TL, Olson MD, Hanson AC, Schroeder DR, Wilder RT, Warner DO.
Propofol Neurotoxicity Is Mediated by p75 Neurotrophin Receptor Activation

Anesthesiology. Pearn, Matthew L. M.D.; Hu, Yue B.S.; Niesman, Ingrid R. M.S.; Patel, Hemal H. Ph.D.; Drummond, John C. M.D.; Roth, David M. Ph.D., M.D.; Akassoglou, Katerina Ph.D.; Patel, Piyush M. M.D.; Head, Brian P. M.S., Ph.D.

January
Ketamine-induced neuroapoptosis in the fetal and neonatal rhesus macaque brain
Anesthesiology. 2012 Jan 4. [Epub ahead of print] Brambrink AM, Evers AS, Avidan MS, Farber NB, Smith DJ, Martin LD, Dissen GA, Creeley CE, Olney JW.