Research Articles
2021 Research Articles
April
Ketamine inhibits neuronal differentiation by regulating brain-derived neurotrophic factor (BDNF) signaling
Toxicology in Vitro April 2021
Repeated exposure to propofol in the neonatal period impairs hippocampal synaptic plasticity and the recognition function of rats in adulthood
Brain Research Bulletin April 2021
March
Dexmedetomidine and Clonidine Attenuate Sevoflurane-Induced Tau Phosphorylation and Cognitive Impairment in Young Mice via α-2 Adrenergic Receptor
Anesthesia & Analgesia March 1, 2021
Predictors of Anesthetic Exposure in Pediatric MRI.
American Journal of Roentgenology March 2021
February
A synthetic peptide rescues rat cortical neurons from anesthetic-induced cell death, perturbation of growth and synaptic assembly
Scientific Reports February 25, 2021
Developmental exposure to general anaesthesia: missed connections?
British Journal of Anaesthesia February 11, 2021
General anaesthesia during infancy reduces white matter micro-organisation in developing rhesus monkeys
British Journal of Anaesthesia February 3, 2021
Regulation of CRMP2 by Cdk5 and GSK-3β participates in sevoflurane-induced dendritic development abnormalities and cognitive dysfunction in developing rats
Toxicology Letters February 3, 2021
January
Expression Signature of lncRNAs and mRNAs in Sevoflurane-Induced Mouse Brain Injury: Implication of Involvement of Wide Molecular Networks and Pathways
International Journal of Molecular Sciences January 30, 2021
Detrimental effects of general anaesthesia on young primates: are we closer to understanding the link?
British Journal of Anaesthesia January 25, 2021
Prenatal Exposure to General Anesthesia and Childhood Behavioral Deficit
Pediatric Anesthesia January 22, 2021
The effects of early anesthesia on neurodevelopment: A systematic review
The Journal of Pediatrics January 19, 2021
The Role of the lncRNA-LRCF in Propofol-Induced Oligodendrocyte Damage in Neonatal Mouse
Neurochemical Research January 7, 2021
Dexmedetomidine attenuates sevoflurane‑induced neurocognitive impairment through α2‑adrenoceptors
Molecular Medicine Reports January 2021
Fundamentals and innovations in regional anaesthesia for infants and children.
Anaesthesia January 2021
General anesthesia activates the mitochondrial unfolded protein response and induces age-dependent, long-lasting changes in mitochondrial function in the developing brain
NeuroToxicology January 2021
2020 Research Articles
December
Resveratrol ameliorates sevoflurane-induced cognitive impairment by activating the SIRT1/NF-κB pathway in neonatal mice
Journal of Nutritional Biochemistry December 31, 2020
Emerging Role of Long Noncoding RNAs in Perioperative Neurocognitive Disorders and Anesthetic-Induced Developmental Neurotoxicity
Anesthesia & Analgesia December 16, 2020
Hypotension and adverse neurodevelopmental outcomes among children with multiple exposures to general anesthesia: Subanalysis of the Mayo Anesthesia Safety in Kids (MASK) Study
Paediatric Anaesthesia December 15, 2020
Sevoflurane-induced neuronal apoptosis in neonatal mice is prevented with intranasal administration of insulin
American Journal of Translational Research December 15, 2020
Neurodevelopmental Outcomes after Premedication with Atropine/Propofol vs Atropine/Atracurium/Sufentanil for Neonatal Intubation: 2-Year Follow-Up of a Randomized Clinical Trial
The Journal of Pediatrics December 8, 2020
Sevoflurane Exposure Induces Neuronal Cell Parthanatos Initiated by DNA Damage in the Developing Brain via an Increase of Intracellular Reactive Oxygen Species
Frontiers in Cellular Neuroscience December 3, 2020
Neonatal exposure to ketamine disrupts developmental synapse unsilencing and predisposes adult mice for stressor-evoked anxiety
Neuropharmacology December 1, 2020
Prenatal sevoflurane exposure: Effects of iron metabolic dysfunction on offspring cognition and potential mechanism
International Journal of Developmental Neuroscience December 1, 2020
November
Prospectively assessed neurodevelopmental outcomes in studies of anaesthetic neurotoxicity in children: a systematic review and meta-analysis
British Journal of Anaesthesia November 27, 2020
Interval-dependent neurotoxicity after multiple ketamine injections in late postnatal mice
Journal of Anesthesia November 24, 2020
Infant isoflurane exposure affects social behaviours, but does not impair specific cognitive domains in juvenile non-human primates
British Journal of Anaesthesia November 13, 2020
The differential effects of isoflurane and sevoflurane on neonatal mice
Scientific Reports November 9, 2020
Early Childhood General Anesthesia and Neurodevelopmental Outcomes in the Avon Longitudinal Study of Parents and Children Birth Cohort
Anesthesiology November 1, 2020
Anesthesia in Childhood and Neurodevelopmental Outcome: The Ongoing Hunt for a Phenome
Anesthesiology November 2020
Hot Topics in Safety for Pediatric Anesthesia
Children November 2020
October
Neuroprotection of the Developing Brain by Dexmedetomidine Is Mediated by Attenuating Single Propofol-induced Hippocampal Apoptosis and Synaptic Plasticity Deficits
Experimental Neurobiology October 31, 2020
Behavior and Regional Cortical BOLD Signal Fluctuations Are Altered in Adult Rabbits After Neonatal Volatile Anesthetic Exposure
Frontiers in Neuroscience October 23, 2020
Attention deficit hyperactivity disorder and educational level in adolescent and adult individuals after anesthesia and abdominal surgery during infancy
PLOS One October 21, 2020
miR-455-3p alleviates propofol-induced neurotoxicity by reducing EphA4 expression in developing neurons
Biomarkers October 18, 2020
An Overview on the Mechanisms of Neuroprotection and Neurotoxicity of Isoflurane and Sevoflurane in Experimental Studies
Brain Research Bulletin October 17, 2020
MicroRNA-204-5p mediates sevoflurane-induced cytotoxicity in HT22 cells by targeting brain-derived neurotrophic factor
Histology & Histopathology October 2, 2020
Androgenic Modulation of the Chloride Transporter NKCC1 Contributes to Age-dependent Isoflurane Neurotoxicity in Male Rats
Anesthesiology October 1, 2020
A Methyltransferase Inhibitor (Decitabine) Alleviates Intergenerational Effects of Paternal Neonatal Exposure to Anesthesia With Sevoflurane
Anesthesia & Analgesia October 2020
Effects of ketamine on neurogenesis, extracellular matrix homeostasis and proliferation in hypoxia-exposed HT22 murine hippocampal neurons.
Biomedical Reports October 2020
Sevoflurane leads to learning and memory dysfunction via breaking the balance of tPA/PAI-1.
Neurochemistry International October 2020
September
Maternal sevoflurane exposure affects differentiation of hippocampal neural stem cells by regulating miR-410-3p and ATN1
Stem Cell Research & Therapy September 29, 2020
Anesthesia plus surgery in neonatal period impairs preference for social novelty in mice at the juvenile age.
Biochemical and Biophysical Research Communications September 24, 2020
Early childhood general anesthesia exposure associated with later developmental delay: A national population-based cohort study
PLOS One September 24, 2020
Protective role of protocatechuic acid in sevoflurane-induced neuron apoptosis, inflammation and oxidative stress in mice
Restorative Neurology and Neuroscience September 24, 2020
Conditions requiring hospitalisations, more than general anaesthesia itself, are associated with diagnosis of learning disorders in children
Anaesthesia Critical Care & Pain Medicine September 23, 2020
Effects of early postnatal sevoflurane exposure on oligodendrocyte maturation and myelination in cerebral white matter of the rat
Biomedicine & Pharmacotherapy September 18, 2020
Neonatal exposure to sevoflurane expands the window of vulnerability to adverse effects of subsequent exposure to sevoflurane and alters hippocampal morphology via decitabine-sensitive mechanisms
Neuroscience Letters September 14, 2020
Sevoflurane Post-Conditioning Ameliorates Neuronal Deficits and Axon Demyelination After Neonatal Hypoxic Ischemic Brain Injury: Role of Microglia/Macrophage
Cellular and Molecular Neurobiology September 2, 2020
Propofol inhibits the expression of Abelson nonreceptor tyrosine kinase without affecting learning or memory function in neonatal rats
Brain and Behavior September 1, 2020
Is Anesthesia Bad for the Brain? Current Knowledge on the Impact of Anesthetics on the Developing Brain.
Anesthesiology Clinics September 2020
Sevoflurane Induces Hippocampal Neuronal Apoptosis by Altering the Level of Neuropeptide Y in Neonatal Rats.
Neurochemical Research September 2020
Tau Contributes to Sevoflurane-induced Neurocognitive Impairment in Neonatal Mice
Anesthesiology September 2020
The protective effect of trilobatin against isoflurane-induced neurotoxicity in mouse hippocampal neuronal HT22 cells involves the Nrf2/ARE pathway
Toxicology September 2020
The Unspoken Question!
Anesthesia & Analgesia September 2020
Yes‑associated protein protects and rescues SH‑SY5Y cells from ketamine‑induced apoptosis
Molecular Medicine Reports September 2020
August
Propofol Exposure Disturbs the Differentiation of Rodent Neural Stem Cells via an miR-124-3p/Sp1/Cdkn1b Axis
Frontiers in Cell and Developmental Biology August 27, 2020
Dexmedetomidine: What’s New for Pediatrics? A Narrative Review
Journal of Clinical Medicine August 24, 2020
Dusp4 Contributes to Anesthesia Neurotoxicity via Mediated Neural Differentiation in Primates
Frontiers in Cell and Developmental Biology August 19, 2020
Research progress and treatment strategies for anesthetic neurotoxicity.
Brain Research Bulletin August 13, 2020
Anesthesia Exposure during Therapy Predicts Neurocognitive Outcomes in Survivors of Childhood Medulloblastoma
The Journal of Pediatrics August 2020
Sevoflurane Induces Learning and Memory Impairment in Young Mice Through a Reduction in Neuronal Glucose Transporter 3
Cellular and Molecular Neurobiology August 2020
July
Regions of the basal ganglia and primary olfactory system are most sensitive to neurodegeneration after extended sevoflurane anesthesia in the perinatal rat.
Neurotoxicology and Teratology July-August 2020
Association between surgical procedures under general anesthesia in infancy and developmental outcomes at 1 year: the Japan Environment and Children’s Study.
Environmental Health and Preventive Medicine July 25, 2020
LncRNA Rik-203 Contributes to Sevoflurane Induced Neurotoxicity?
Frontiers in Medicine (Lausanne) July 22, 2020
Increasing the interval between repeated anesthetic exposures reduces long‐lasting synaptic changes in late post‐natal mice
Journal of Neurochemistry July 8, 2020
Coenzyme Q10 Alleviates sevoflurane‑induced Neuroinflammation by Regulating the Levels of Apolipoprotein E and Phosphorylated Tau Protein in Mouse Hippocampal Neurons
Molecular Medicine Reports July 2020
Maternal Treadmill Exercise Reduces the Neurotoxicity of Prenatal Sevoflurane Exposure in Rats via Activation of p300 Histone Acetyltransferase.
Neurochemical Research July 2020
Neonatal Isoflurane Anesthesia or Disruption of Postsynaptic Density-95 Protein Interactions Change Dendritic Spine Densities and Cognitive Function in Juvenile Mice.
Perioperative Medicine July 2020
Neurotoxicity effects of anesthetic exposure on the developing brain of non-human primates
Medical Hypotheses July 2020
June
LncRNA LINC00641 Sponges miR-497-5p to Ameliorate Neural Injury Induced by Anesthesia via Up-Regulating BDNF.
Frontiers in Molecular Neuroscience June 30, 2020
General anesthesia affecting on developing brain: evidence from animal to clinical research.
Journal of Anesthesia June 29, 2020
Autophagic Network Analysis of the Dual Effect of Sevoflurane on Neurons Associated with GABARAPL1 and 2.
BioMed Research International June 26, 2020
Dexmedetomidine in children – when should we be using it?
Anaesthesia June 24, 2020
Neonatal sevoflurane exposure induces impulsive behavioral deficit through disrupting excitatory neurons in the medial prefrontal cortex in mice.
Translational Psychiatry June 20, 2020
An appropriate level of autophagy reduces emulsified isoflurane-induced apoptosis in fetal neural stem cells.
Neural Regeneration Research June 19, 2020
Safety of anesthetic exposure on the developing brain – Do we have the answer yet?
Journal of Anaesthesiology Clinical Pharmacology June 15, 2020
Propofol Attenuates Isoflurane-Induced Neurotoxicity and Cognitive Impairment in Fetal and Offspring Mice
Anesthesia & Analgesia June 10, 2020
Use of Dexmedetomidine and Opioids as the Primary Anesthetic in Infants and Young Children: A Retrospective Cohort Study
Pediatric Anesthesia June 8, 2020
Anesthetic Drugs in Children and Pregnant Women – Implications of the Recent FDA Warning.
Harefuah June 2020
May
Optimization of Ultrasound Backscatter Spectroscopy to Assess Neurotoxic Effects of Anesthesia in the Newborn Non-human Primate Brain
Ultrasound in Medicine and Biology May 29, 2020
Neonatal Exposure to Anesthesia Leads to Cognitive Deficits in Old Age: Prevention With Intranasal Administration of Insulin in Mice
Neurotoxicity Research May 26, 2020
Neonatal Ketamine Alters High-Frequency Oscillations and Synaptic Plasticity in the Subiculum But Does not Affect Sleep Macrostructure in Adolescent Rats
Frontiers in Systems Neuroscience May 26, 2020
Neuroendocrine, epigenetic, and intergenerational effects of general anesthetics
World Journal of Psychiatry May 19, 2020
Upregulation of miR-215 attenuates propofol-induced apoptosis and oxidative stress in developing neurons by targeting LATS2.
Molecular Medicine May 6, 2020
Neurotoxicity of Sub-Anesthetic Doses of Sevoflurane and Dexmedetomidine Co-Administration in Neonatal Rats
NeuroToxicology May 5, 2020
Upregulation of miR-496 Rescues Propofol-Induced Neurotoxicity by Targeting Rho Associated Coiled-Coil Containing Protein Kinase 2 (ROCK2) in Prefrontal Cortical Neurons
Current Neurovascular Research May 5, 2020
Acetyl-l-carnitine Does Not Prevent Neurodegeneration in a Rodent Model of Prolonged Neonatal Anesthesia
Neurotoxicology and Teratology May 3, 2020
Standards for Preclinical Research and Publications in Developmental Anaesthetic Neurotoxicity: Expert Opinion Statement From the SmartTots Preclinical Working Group
British Journal of Anaesthesia May 2020
April
Potential Neurodevelopmental Effects of Pediatric Intensive Care Sedation and Analgesia: Repetitive Benzodiazepine and Opioid Exposure Alters Expression of Glial and Synaptic Proteins in Juvenile Rats
Critical Care Explorations April 29, 2020
The Effects of Hesperidin on Neuronal Apoptosis and Cognitive Impairment in the Sevoflurane Anesthetized Rat are Mediated Through the PI3/Akt/PTEN and Nuclear Factor-κB (NF-κB) Signaling Pathways
Medical Science Monitor April 16, 2020
HSP90 inhibitor 17AAG attenuates sevoflurane-induced neurotoxicity in rats and human neuroglioma cells via induction of HSP70
Journal of Translational Medicine April 15, 2020
The Role of Histone Acetylation in the Sevoflurane-induced Inhibition of Neurogenesis in the Hippocampi of Young Mice.
Neuroscience April 15, 2020
Pediatric anesthesiologists’ attitudes about neurotoxicity and the FDA drug safety communication
Pediatric Anesthesia April 12, 2020
Iron Overload Contributes to General Anaesthesia-Induced Neurotoxicity and Cognitive Deficits
Journal of Neuroinflammation April 11, 2020
PDE-7 Inhibitor BRL-50481 Reduces Neurodegeneration and Long-Term Memory Deficits in Mice Following Sevoflurane Exposure
ACS Chemical Neuroscience April 9, 2020
Sevoflurane Inhibits Neuronal Migration and Axon Growth in the Developing Mouse Cerebral Cortex
Aging April 9, 2020
How Should Trainees’ Influences on Postoperative Outcomes Be Disclosed?
AMA Journal of Ethics April 2020
March
Inhibition of the electron transport chain in propofol induced neurotoxicity in zebrafish embryos
Neurotoxicology and Teratology March-April 2020
Ketamine promotes the neural differentiation of mouse embryonic stem cells by activating mTOR
Molecular Medicine Reports March 30, 2020
GAS, PANDA, and MASK: Comment. Williams & Sartorelli.
Anesthesiology March 26, 2020
Effects of propofol on hippocampal neuron viability
Child’s Nervous System March 16, 2020
Evaluation of the Toxicity of Sugammadex in Zebrafish Larvae
Journal of Korean Medical Science March 9, 2020
Compound Porcine Cerebroside and Ganglioside Injection (CPCGI) Attenuates Sevoflurane-Induced Nerve Cell Injury by Regulating the Phosphorylation of p38 MAP Kinase (p38MAPK)/Nuclear Factor kappa B (NF-κB) Pathway.
Medical Science Monitor March 1, 2020
Dexmedetomidine attenuates ethanol-induced inhibition of hippocampal neurogenesis in neonatal mice
Toxicology and Applied Pharmacology March 1, 2020
Anesthesia for Major Surgery in the Neonate
Anesthesiology Clinics March 2020
GAS, PANDA, and MASK: Comment
Anesthesiology March 2020
GAS, PANDA, and MASK: Reply. Vutskits & Culley
Anesthesiology March 2020
Neurotoxicity of Drugs in Children During Antenatal and Postnatal Development Periods
American Journal of Pediatrics March 2020
Sex differences in neurodevelopmental abnormalities caused by early-life anaesthesia exposure: a review.
British Journal of Anaesthesia March 2020
February
False Interpretation of Scientific Data Leads to Biased Conclusions About the Association Between Cesarean Deliveries Under General Anesthesia and Risk of Autism Spectrum Disorder.
Journal of Autism and Developmental Disorders February 19, 2020
Resveratrol Mitigates Sevoflurane-Induced Neurotoxicity by the SIRT1-Dependent Regulation of BDNF Expression in Developing Mice
Oxidative Medicine and Cellular Longevity February 19, 2020
Neuroprotective effects of dexmedetomidine against the ketamine-induced disturbance of proliferation and differentiation of developing neural stem cells in the subventricular zone
BMC Neuroscience February 16, 2020
Cyclophilin D Contributes to Anesthesia Neurotoxicity in the Developing Brain
Frontiers in Cell and Developmental Biology February 11, 2020
MicroRNA-582-5p reduces propofol-induced apoptosis in developing neurons by targeting ROCK1.
Current Neurovascular Research February 7, 2020
Definition of Clinical Outcomes in Pediatric Anesthesia Research: It Is Like the Tower of Babel!
Anesthesia & Analgesia February 2020
Desflurane and Surgery Exposure During Pregnancy Decrease Synaptic Integrity and Induce Functional Deficits in Juvenile Offspring Mice.
Neurochemical Research February 2020
Exogenous GM1 Ganglioside Attenuates Ketamine-Induced Neurocognitive Impairment in the Developing Rat Brain
Anesthesia & Analgesia February 2020
General anesthesia risk across pediatric surgical specialties: Low in otolaryngology
International Journal of Pediatric Otorhinolaryngology February 2020
January
Dexmedetomidine Alleviates Neurogenesis Damage Following Neonatal Midazolam Exposure in Rats through JNK and P38 MAPK Pathways
ACS Chemical Neuroscience January 30, 2020
Effects of embryonic propofol exposure on axonal growth and locomotor activity in zebrafish
Journal of Applied Toxicology January 30, 2020
The mTOR Inhibitor Rapamycin Prevents General Anesthesia-Induced Changes in Synaptic Transmission and Mitochondrial Respiration in Late Postnatal Mice
Frontiers in Cellular Neuroscience January 28, 2020
Downregulation of CDK5 Restores Sevoflurane-Induced Cognitive Dysfunction by Promoting SIRT1-Mediated Autophagy.
Cellular and Molecular Neurobiology January 16, 2020
Conflicting Actions of Inhalational Anesthetics, Neurotoxicity and Neuroprotection, Mediated by the Unfolded Protein Response
International Journal of Molecular Sciences January 10, 2020
General Anesthetic-Induced Neurotoxicity in the Immature Brain: Reevaluating the Confounding Factors in the Preclinical Studies.
Hindawi January 8, 2020
Exposure to Surgery and Anesthesia in Early Childhood and Subsequent Use of Attention Deficit Hyperactivity Disorder Medications.
Anesthesia & Analgesia January 8, 2020
Paediatric Anaesthesia Neurotoxicity: Bring Back the Papoose Board?
Oral Health January 7, 2020
Effects of Xenon-Based Anesthetic Exposure on the Expression Levels of Polysialic Acid Neural Cell Adhesion Molecule (PSA-NCAM) on Human Neural Stem Cell-Derived Neurons.
Molecular Neurobiology January 2020
General anesthesia in infants: neurobiological and neuropsychological concerns.
Boletin medico del Hospital Infantil de Mexico 2020
Ketamine exerts neurotoxic effects on the offspring of pregnant rats via the Wnt/β-catenin pathway.
Environmental Science and Pollution Research January 2020
NR2B receptor- and calpain-mediated KCC2 cleavage resulted in cognitive deficiency exposure to isoflurane
NeuroToxicology January 2020
Paeonol attenuates isoflurane anesthesia-induced hippocampal neurotoxicity via modulation of JNK/ERK/P38MAPK pathway and regulates histone acetylation in neonatal rat.
Journal of Maternal-Fetal and Neonatal Medicine January 2020
Vitexin improves neuron apoptosis and memory impairment induced by isoflurane via regulation of miR-409 expression.
Advances in Clinical and Experimental Medicine January 2020
2018 Research Articles
December
Drug Design, Development and Therapy December 28, 2018
Electron microscopy techniques employed to explore mitochondrial defects in the developing rat brain following ketamine treatment.
Experimental Cell Research. December 15, 2018
What anesthetic technique should we use in order to prevent alterations in the neuro development over the pediatric population?
Revista de la Facultad de Ciencias Médicas de Córdoba December 12, 2018
Lipidomics reveals a systemic energy deficient state that precedes neurotoxicity in neonatal monkeys after sevoflurane exposure.
Analytica Chimica Acta. December 11, 2018
CORRESPONDENCE: Reply to Ritchie‐McLean, Susanna; Wilmshurst, Sally, regarding their comment “Can population cohort studies assess the long‐term impact of anesthesia in children?”
Pediatric Anesthesia. December 4, 2018
Sevoflurane induces neurotoxicity in the developing rat hippocampus by upregulating connexin 43 via the JNK/c-Jun/AP-1 pathway.
Biomedicine & Pharmacotherapy December 2018
Neurocognitive Impact of Anesthesia in Children
Advances in Anesthesia. December 2018
November
Urologic Clinics of North America. November 2018
Anesthesia affects excitatory/inhibitory synapses during the critical synaptogenic period in the hippocampus of young mice: Importance of sex as a biological variable.
Neurotoxicology. November 28, 2018
A Systematic Review and Narrative Synthesis on the histological and neurobehavioral long term effects of dexmedetomidine.
Pediatric Anesthesia. November 26, 2018
A case report of multiple anesthesia for pediatric surgery: 80 anesthesia applications in a period of 6 years.
BMC Anesthesiology. November 20, 2018
Early life exposure to extended general anesthesia with isoflurane and nitrous oxide reduces responsivity on a cognitive test battery in the nonhuman primate.
Neurotoxicology. November 14, 2018
Influence of Surgical Procedures and General Anesthesia on Child Development Before Primary School Entry Among Matched Sibling Pairs.
JAMA Pediatrics. November 5, 2018
October
Current Treatment Options in Neurology. October 13, 2018
Fetal Surgery Decreases Anesthesia-Induced Neuroapoptosis in the Mid-Gestational Fetal Ovine Brain
Fetal Diagnosis and Therapy. October 12, 2018
MicroRNA-107 regulates anesthesia-induced neural injury in embryonic stem cell derived neurons
IUBMB Life. October 11, 2018
CORRESPONDENCE: Can population cohort studies assess the long‐term impact of anesthesia in children?
Pediatric Anesthesia. October 9, 2018
September
Brain Research Bulletin. September 29, 2018
Signaling network between the dysregulated expression of microRNAs and mRNAs in propofol-induced developmental neurotoxicity in mice
Scientific Reports. September 21, 2018
Reduction the risk in pediatric anesthesia-what should we know-what should we do
Wiener Medizinische Wochenschrift. September 18, 2018
Sedative and Anesthetic Neurotoxicity in Infants and Young Children: Not Just an Operating Room Concern
The Journal of Pediatrics. September 2018
Lipid profiling as an effective approach for identifying biomarkers/adverse events associated with pediatric anesthesia
Toxicology and Applied Pharmacology. September 2018
Intravenous versus inhalational anesthesia for pediatric inpatient surgery – A systematic review and meta-analysis.
Journal of Clinical Anesthesia. September 2018
Anesthesia and the developing brain: A way forward for laboratory and clinical research
Paediatric Anaesthesia. September 2018
August
Neuropsychiatric Disease and Treatment. August 28, 2018
N-acetylcysteine prevents ketamine-induced adverse effects on development, heart rate and monoaminergic neurons in zebrafish
Neuroscience Letters. August 24, 2018
Dexmedetomidine mitigates sevoflurane-induced cell cycle arrest in hippocampus
Journal of Anesthesia. August 20, 2018
Cognitive Impairment and Endoplasmic Reticulum Stress Induced by Repeated Short-Term Sevoflurane Exposure in Early Life of Rats
Frontiers in Psychiatry. August 2, 2018
Expert Available to Discuss Children and Anesthesia
American Society of Anesthesiologists. August 1, 2018
The effect of xenon-augmented sevoflurane anesthesia on intraoperative hemodynamics and early postoperative neurocognitive function in children undergoing cardiac catheterization: A randomized controlled pilot trial
Paediatric Anaesthesia. August 2018
Role of epigenetic mechanisms in transmitting the effects of neonatal sevoflurane exposure to the next generation of male, but not female, rats
British Journal of Anaesthesia. August 2018
Neonatal exposure of ketamine inhibited the induction of hippocampal long-term potentiation without impairing the spatial memory of adult rats
Cognitive Neurodynamics. August 2018
July
Frontiers in Physiology July 31, 2018
Early Developmental Exposure to General Anesthetic Agents in Primary Neuron Culture Disrupts Synapse Formation via Actions on the mTOR Pathway
International Journal of Molecular Sciences. July 26, 2018
Neonatal anesthesia exposure impacts brain microRNAs and their associated neurodevelopmental processes
Scientific Reports. July 13, 2018
Comparison of neurotoxicity of dexmedetomidine as an adjuvant in brachial plexus block in rats of different age
Neurotoxicology and Teratology. July 11, 2018
When Your Child Needs Surgery, Don’t Fear Anesthesia, Says American Society of Anesthesiologists
American Society of Anesthesiologists. July 9, 2018
Long-Term Neurobehavioral Consequences of a Single Ketamine Neonatal Exposure in Rats: Effects on Cellular Viability and Glutamate Transport in Frontal Cortex and Hippocampus
Neurotoxicity Research. July 2, 2018
Pediatric Neuroanesthesia
Current Opinion in Anaesthesiology. July 2018
June
Anesthesiology Research and Practice. June 19, 2018
Does pediatric anesthesia cause brain damage? Addressing parental and provider concerns in light of compelling animal studies and seemingly ambivalent human data.
Korean Journal of Anesthesiology. June 4, 2018
Epidemiology of general anesthesia prior to age 3 in a population-based birth cohort
Pediatric Anesthesia. June 2018
Role of autophagy in sevoflurane-induced neurotoxicity in neonatal rat hippocampal cells.
Brain Research Bulletin June 2018
The impact of general anesthesia on child development and school performance: a population-based study
Paediatric Anaesthesia. June 2018
The postoperative effect of sevoflurane inhalational anesthesia on cognitive function and inflammatory response of pediatric patients.
European Review for Medical and Pharmacological Sciences. June 2018
May
Journal of Pediatric Pharmacology and Therapeutics. May – June 2018
Choosing Wisely in pediatric anesthesia: An interpretation from the German Scientific Working Group of Paediatric Anaesthesia (WAKKA).
Pediatric Anesthesia. May 30, 2018
Spinal anesthesia for surgery longer than 60 min in infants: experience from the first 2 years of a spinal anesthesia program.
Journal of Anesthesia. May 28, 2018
Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain.
Journal of Visualized Experiments. May 12, 2018
Spinal anesthesia instead of general anesthesia for infants undergoing tendon Achilles lengthening.
Local and Regional Anesthesia. May 3, 2018
Estimating pediatric general anesthesia exposure: Quantifying duration and risk
Pediatric Anesthesia. May 2, 2018
Fentanyl Induces Cerebellar Internal Granular Cell Layer Apoptosis in Healthy Newborn Pigs
Frontiers in Neurology May 1, 2018
April
Scientific Reports. April 28, 2018
Effect of multiple neonatal sevoflurane exposures on hippocampal apolipoprotein E levels and learning and memory abilities
Pediatrics & Neonatology. April 2018
Persistent alteration in behavioural reactivity to a mild social stressor in rhesus monkeys repeatedly exposed to sevoflurane in infancy.
British Journal of Anaesthesia. April 2018
A neurosteroid analogue with T-type calcium channel blocking properties is an effective hypnotic, but is not harmful to neonatal rat brain.
British Journal of Anaesthesia. April 2018
Neuropsychological and Behavioral Outcomes after Exposure of Young Children to Procedures Requiring General Anesthesia: The Mayo Anesthesia Safety in Kids (MASK) Study.
Anesthesiology. April 2018
Clinical Evidence for Any Effect of Anesthesia on the Developing Brain.
Anesthesiology. April 2018
Anesthesia and Neurodevelopment in Children – perhaps the end of the beginning.
Anesthesiology. April 2018
Young Brain and Anesthesia: Refusal of Anesthesia Is Not an Option!
Anesthesiology. April 2018
The Challenges of Translation.
Anesthesiology. April 2018
Exposure of the Developing Brain to General Anesthesia: What is the Animal Evidence?
Anesthesiology. April 2018
SmartTots Update Regarding Anesthetic Neurotoxicity in the Developing Brain
Anesthesia & Analgesia. April 2018
SmartTots: Quo Vadis?
Anesthesia & Analgesia. April 2018
March
Pediatric Radiology. March 17, 2018
Effects on adult cognitive function after neonatal exposure to clinically relevant doses of ionising radiation and ketamine in mice
British Journal of Anaesthesia. March 2018
Postoperative Delirium, Learning, and Anesthetic Neurotoxicity: Some Perspectives and Directions.
Frontiers in Neurology. March 2018
Reducing the Number of Anesthetic Exposures in the Early Years of Life: Circumcision and Myringotomy as an Example.
Clinical Pediatrics. March 2018
A Systematic Review of Risk Factors Associated With Cognitive Impairment After Pediatric Critical Illness.
Pediatric Critical Care Medicine. March 2018
S100β in newborns after C-section with general vs. epidural anesthesia: a prospective observational study.
Acta Anaesthesiologica Scandinavica. March 2018
February
Current Opinion in Anaesthesiology. February 9, 2018
Changes in sensory processing after anesthesia in toddlers.
Minerva Anestesiologica. February 5, 2018
Lipoic acid inhibited desflurane-induced hippocampal neuronal apoptosis through Caspase3 and NF-KappaB dependent pathway.
Tissue & Cell.” February 2018
January
Neurotoxicology and Teratology. January – February 2018
Changes in tissue and cerebral oxygenation following spinal anesthesia in infants: a prospective study.
Journal of Anesthesia. January 12, 2018
Reducing sedation for pediatric body MRI using accelerated and abbreviated imaging protocols.
Pediatric Radiology. January 2018
Food and Drug Administration warning on anesthesia and brain development: implications for obstetric and fetal surgery.
American Journal of Obstetrics and Gynecology. January 2018
An International, Multicenter, Observational Study of Cerebral Oxygenation during Infant and Neonatal Anesthesia
Anesthesiology January 2018
Influence of nitrous oxide on granule cell migration in the dentate gyrus of the neonatal rat
BioMed Research. 2018
2016 Research Articles
December
REUTERS Dec 29, 2016
FDA warns of anesthesia risk in pregnant women, kids under 3
CBS NEWS HEALTHDAY December 15, 2016
Exposure to sevoflurane anesthesia during development does not impair aspects of attention during adulthood in rats
Neurotoxicol Teratol. 2016 Dec 2
Caffeine combined with sedative/anesthetic drugs triggers widespread neuroapoptosis in a mouse model of prematurity
J Matern Fetal Neonatal Med. 2016 Dec 7
Anesthesia Kills Brain Cells, but What Does It Mean?
Anesthesiology Editorial Views December 2016
A holistic approach to anesthesia-induced neurotoxicity and its implications for future mechanistic studies
Neurotoxicology and Teratology 2016.12.004
November
JAMA Pediatr. November 7, 2016
The Relevance of Anesthetic Drug-Induced Neurotoxicity
AMA Pediatr. 2016
Review of preclinical studies on pediatric general anesthesia-induced developmental neurotoxicity
Neurotoxicol Teratol. 2016 Nov 18
Neonatal Repeated Exposure to Isoflurane not Sevoflurane in Mice Reversibly Impaired Spatial Cognition at Juvenile-Age
Neurochem Res. 2016 Nov 24
Lasting impact of general anesthesia on the brain: mechanism and relevance
Nature Reviews Neuroscience
Anesthetic Neurotoxicity: New Findings and Future Directions
The Journal of Pediatrics
Neonatal inhibition of Na+-K+-2Cl−-cotransporter prevents ketamine induced spatial learning and memory impairments
Neurotoxicology and Teratology 2016.11.01
Isoflurane exposure leads to apoptosis of neurons and oligodendrocytes in 20- and 40-day old rhesus macaques
Neurotoxicology and Teratology 2016.11.06
Anesthetic neurotoxicity: Apoptosis and autophagic cell death mediated by calcium dysregulation
Neurotoxicology and Teratology 2016.11.04
October
Anesthesia Patient Safety Foundation. October 2016
Is a short anesthetic exposure in children safe? Time will tell: a focused commentary of the GAS and PANDA trials
Ann Transl Med. 2016 Oct
Do anesthetics harm the developing human brain? An integrative analysis of animal and human studies
Neurotoxicol Teratol. 2016 Oct 26
Minimally invasive biomarkers of general anesthetic-induced developmental neurotoxicity
Neurotoxicology and Teratology 2016.10.07
The genetics of isoflurane-induced developmental neurotoxicity
Neurotoxicology and Teratology 2016.10.07
Neurogenesis and developmental anesthetic neurotoxicity
Neurotoxicology and Teratology 2016.10.01
September
Brain and Behavior
Carbon monoxide and anesthesia-induced neurotoxicity.
Neurotoxicol Teratol. 2016 Sep 9
Astragaloside IV protects new born rats from anesthesia-induced apoptosis in the developing brain.
Exp Ther Med. 2016 Sep;12
Isoflurane provides neuroprotection in neonatal hypoxic ischemic brain injury by suppressing apoptosis.
Rev Bras Anestesiol. 2016
Long-lasting behavioral effects in neonatal mice with multiple exposures to ketamine-xylazine anesthesia.
Neurotoxicol Teratol. 2016 Sep 10
Altered hippocampal microRNA expression profiles in neonatal rats caused by sevoflurane anesthesia: MicroRNA profiling and bioinformatics target analysis.
Exp Ther Med. 2016 Sep;12
Long-term Fate Mapping to Assess the Impact of Postnatal Isoflurane Exposure on Hippocampal Progenitor Cell Productivity
Anesthesiology 2016 Sep 21
The effect of anaesthesia on the infant brain
Early Hum Dev. 2016 Sep 10
Intelligence quotient scores at the age of 6 years in children anaesthetised before the age of 5 years
26 September 2016
August
Journal of Bioenergetics and Biomembranes August 2016
June
Drug and Chemical Toxicology. June 2, 2016
May
Congenital Heart Disease, May/June 2016
April
Neurotoxicology and Teratology, April 2016
Ketamine exposure during embryogenesis inhibits cellular proliferation in rat fetal cortical neurogenic regions
Acta Anaesthesiologica Scandinavica, April 2016
Paediatric anaesthesia and neurotoxicity: can we translate findings from animals to humans?
Minerva Anestesiologica, April 2016
Oral Clefts and Academic Performance in Adolescence: The Impact of Anesthesia-Related Neurotoxicity, Timing of Surgery, and Type of Oral Clefts
Cleft Palate Craniofac J., April 2016
Increasing cumulative exposure to volatile anesthetic agents is associated with poorer neurodevelopmental outcomes in children with hypoplastic left heart syndrome.
J Thorac Cardiovasc Surg., April 2016
rno-miR-665 targets BCL2L1 (Bcl-xl) and increases vulnerability to propofol in developing astrocytes
J Neurochem, April 2016
Xenon depresses aEEG background voltage activity whilst maintaining cardiovascular stability in sedated healthy newborn pigs
J Neurol Sci. April 2016
March
International Journal of Developmental Neuroscience, March 2016
Potential neurotoxicity of anesthetic drugs in young children: who cares? A survey among European anesthetists
Minerva Anestesiologica, March 2016
Preterm Versus Term Children: Analysis of Sedation/Anesthesia Adverse Events and Longitudinal Risk
Pediatrics, March 2016
Neuronal apoptosis may not contribute to the long-term cognitive dysfunction induced by a brief exposure to 2% sevoflurane in developing rats
Biomedicine & Pharmacotherapy, March 2016
Lithium Protects Against Anesthesia Neurotoxicity in the Infant Primate Brain
Scientific Reports, March 2016
Dexmedetomidine and ketamine show distinct patterns of cell degeneration and apoptosis in the developing rat neonatal brain
The Journal of Maternal-Fetal & Neonatal Medicine, March 2016
The mitochondrial division inhibitor Mdivi-1 rescues mammalian neurons from anesthetic-induced cytotoxicity
Mol Brain, March 2016
February
Archives of Disease in Childhood, February, 2016
Inflammation Increases Neuronal Sensitivity to General Anesthetics.
Anesthesiology, February 2016.
Isoflurane Is More Deleterious to Developing Brain Than Desflurane: The Role of the Akt/GSK3β Signaling Pathway
BioMed Research International, February, 2016
January
Acta Anaesthesiologica Scandinavica, January, 2016
Increased mitochondrial ATP production capacity in brain of healthy mice and a mouse model of isolated complex I deficiency after isoflurane anesthesia
Journal of Inherited Medicine, January 2016
Acute and Long-Term Effects of Brief Sevoflurane Anesthesia During the Early Postnatal Period in Rats
Toxicol. Sci., January 2016
α-Lipoic acid inhibits sevoflurane-induced neuronal apoptosis through PI3K/Akt signalling pathway
Cell Biochemistry and Function, January 2016
Midazolam dose correlates with abnormal hippocampal growth and neurodevelopmental outcome in preterm infants
Annals of Neurology, January 2016
Differential Suppression of Spontaneous and Noxious-evoked Somatosensory Cortical Activity by Isoflurane in the Neonatal Rat
Anesthesiology, January 2016
Etomidate exposure in early infant mice does not induce apoptosis or affect behavior
Acta Anaesthesiol Scand, January 2016
2014 Research Articles
December
Contemp Clin Trials, December 2014.
Propofol inhibits proliferation and induces neuroapoptosis of hippocampal neurons in vitro via downregulation of NF-κB p65 and Bcl-2 and upregulation of caspase-3
Cell Biochem Funct, December 2014.
November
Anesthesia & Analgesia, November 2014.
Vitamin C Attenuates Isoflurane-Induced Caspase-3 Activation and Cognitive Impairment
Molecular Neurobiology, November 2014.
October
Journal of Neurosurgical Anesthesiology, October 2014.
Clinical Research Into Anesthetic Neurotoxicity: Does Anesthesia Cause Neurological Abnormalities in Humans?
Journal of Neurosurgical Anesthesiology, October 2014.
Engaging Stakeholders in Research Related to Anesthesia and Neurodevelopment in Children
Journal of Neurosurgical Anesthesiology, October 2014.
Isoflurane Impairs the Capacity of Astrocytes to Support Neuronal Development in a Mouse Dissociated Coculture Model
Journal of Neurosurgical Anesthesiology, October 2014.
Ketamine Affects the Neurogenesis of Rat Fetal Neural Stem Progenitor Cells via the PI3K/Akt-p27 Signaling Pathway.
Birth defects research. Part B, Developmental and reproductive toxicology, October 2014.
Neurodevelopmental Outcomes After Initial Childhood Anesthetic Exposure Between Ages 3 and 10 Years Journal of Neurosurgical Anesthesiology, October 2014.
Pediatric Surgeons and Anesthesiologists Expand the Dialogue on the Neurotoxicity Question, Rationale for Early and Delayed Surgeries, and Practice Changes While Awaiting Definitive Evidence
Journal of Neurosurgical Anesthesiology, October 2014.
Postoperative Cognitive Function Following General Versus Regional Anesthesia: A Systematic Review Journal of Neurosurgical Anesthesiology, October 2014.
Report of the Fourth PANDA Symposium on Anesthesia and Neurodevelopment in Children Journal of Neurosurgical Anesthesiology, October 2014.
Review: effects of anesthetics on brain circuit formation.
Journal of Neurosurgical Anesthesiology, October 2014.
September
Paediatric Anaesthesia, September 2014.
Cognitive Outcomes After Infant Spinal Anesthesia: The Other Side of the Coin
Anesthesia & Analgesia, September 2014.
Neurosurgical conditions and procedures in infancy are associated with mortality and academic performances in adolescence: a nationwide cohort study
Pediatric Anesthesia, September 2014.
Sevoflurane induces tau phosphorylation and glycogen synthase kinase 3β activation in young mice
Anesthesiology, September 2014.
August
Anesthesia & Analgesia, Aug. 5, 2014.
Long term neurotoxicity by general anesthetics in infants
Anaesthesia, Pain & Intensive Care, 2014.
July
Cell Biol Int., July 23, 2014.
Both JNK and P38 MAPK pathways participate in the protection by dexmedetomidine against isoflurane-induced neuroapoptosis in the hippocampus of neonatal rats.
Brain Res Bull, July 2014.
Dexmedetomidine provides neuroprotection: impact on ketamine-induced neuroapoptosis in the developing rat brain
Acta Anaesthesiol Scand, July 2014.
Down-regulation of MicroRNA-21 Is Involved in the Propofol-induced Neurotoxicity Observed in Human Stem Cell-derived Neurons.
Anesthesiology, July 2014.
Endocrine and Neurobehavioral Abnormalities Induced by Propofol Administered to Neonatal Rats.
Anesthesiology, July 2014.
Erythropoietin protects newborn rat against sevoflurane-induced neurotoxicity Pediatric Anesthesia, July 2014.
June
The Cleft Palate-Craniofacial Journal, June 18, 2014.
Cognitive Outcome after Spinal Anesthesia and Surgery During Infancy
Anesthesia & Analgesia, June 2014.
Comparison of neurodegeneration and cognitive impairment in neonatal mice exposed to propofol or isoflurane.
PLoS One, June 2014.
Effect of General Anesthesia in Infancy on Long-Term Recognition Memory in Humans and Rats
Neuropsychopharmacology, June 2014.
Impact of ketamine on learning and memory function, neuronal apoptosis and its potential association with miR-214 and PTEN in adolescent rats.
PLoS One, June 2014.
The Neonatologist’s Role in Pediatric Anesthesia Neurotoxicity
JAMA Pediatrics, June 2014.
May
International Journal of Neuroscience, May 13, 2014.
General anaesthetics and the developing brain: an overview.
Anaesthesia, May 14, 2014.
Propofol anesthesia induces proapoptotic tumor necrosis factor-α and pro-nerve growth factor signaling and prosurvival Akt and XIAP expression in neonatal rat brain.
J Neurosci Res, May 14, 2014.
Repeated Administration of Ketamine can Induce Hippocampal Neurodegeneration and Long-Term Cognitive Impairment via the ROS/HIF-1α Pathway in Developing Rats.
Cell Physiol Biochem, May 2014.
Neurotoxic effects of dexmedetomidine in fetal cynomolgus monkey brains
J Toxicol Sci, 2014.
April
Neurobiol Dis, April 26, 2014.
Comparative Analysis of Outcome Measures Used in Examining Neurodevelopmental Effects of Early Childhood Anesthesia Exposure
Anesthesiology, April 2014.
Dexmedetomidine Reduces Isoflurane-Induced Neuroapoptosis Partly by Preserving P13K/Akt Pathway in the Hippocampus of Neonatal Rats
PLoS One, April 2014.
Dual effects of ketamine: neurotoxicity versus neuroprotection in anesthesia for the developing brain
J Neurosurg Anesthesiol, April 2014.
Involvement of RAGE in isoflurane-induced neuronal apoptosis
The FASEB Journal, April 2014.
Isoflurane exposure in newborn rats induces long-term cognitive dysfunction in males but not females Neuropharmacology, April 2014.
Neuroprotective gases–fantasy or reality for clinical use?
Prog Neurobiol, April 2014.
Sevoflurane in combination with propofol, not thiopental, induces a more robust neuroapoptosis than sevoflurane alone in the neonatal mouse brain
Journal of Anesthesia, April 2014.
The role of miR-21 in propofol-induced neurotoxicity in developing human neurons (1093.2)
The FASEB Journal, April 2014.
March
Int. J. Mol. Sci., March 3, 2014.
Repeated Exposure to Anesthetic Ketamine Can Negatively Impact Neurodevelopment in Infants: A Prospective Preliminary Clinical Study.
J Child Neurol, March 20, 2014.
Anesthesia considerations in pediatric glaucoma management
Curr Opin Ophthalmol, March 2014.
Anaesthetics-Induced Neurotoxicity in Developing Brain: An Update on Preclinical Evidence
Brain Sci, March 2014.
Anesthetic neurotoxicity
Anesthesiol Clin, March 2014.
Exposure to general anesthesia in early life and the risk of attention deficit/hyperactivity disorder development: a nationwide, retrospective matched-cohort study
Paediatr Anaesth, March 2014.
Inflammation and the developing brain: consequences for hippocampal neurogenesis and behavior.
Neurosci Biobehav Rev., March 2014.
Isoflurane-induced Apoptosis of Neurons and Oligodendrocytes in the Fetal Rhesus Macaque Brain
Anesthesiology, March 2014.
Neonatal Morphine in Extremely and Very Preterm Neonates: Its Effect on the Developing Brain, a Review
J Matern Fetal Neonatal Med, March 2014.
The association between brain injury, perioperative anesthetic exposure, and 12-month neurodevelopmental outcomes after neonatal cardiac surgery: a retrospective cohort study.
Paediatr Anaesth, March 2014.
The potential dual effects of sevoflurane on AKT/GSK3beta signaling pathway
Med Gas Res, March 2014.
February
Med Gas Res, February 2014.
Anesthesia and the Developing Brain: Relevance to the Pediatric Cardiac Surgery
Brain Sci, February 2014.
Inhibition of aberrant cyclin-dependent kinase 5 activity attenuates isoflurane neurotoxicity in the developing brain
Neuropharmacology, February 2014.
January
Br. J. Anaesth, January 2014.
Physiological disturbance may contribute to neurodegeneration induced by isoflurane or sevoflurane in 14 day old rats
PLoS One, January 2014.
Subclinical Carbon Monoxide Limits Apoptosis in the Developing Brain After Isoflurane Exposure
Anesth Analg, January 2014.
2012 Research Articles
December
British Journal of Anaesthesia. 2012 Dec;109 Suppl 1. McCann ME, Soriano SG.
Early Developmental Exposure to Volatile Anesthetics Causes Behavioral Defects in Caenorhabditis elegans Anesth Analg. 2012 Dec 7. [Epub ahead of print] Gentry KR, Steele LM, Sedensky MM, Morgan PG.
November
October
J Neurosurg Anesthesiol. 2012 Oct;24(4):362-7. Mintz CD, Wagner M, Loepke AW.
Anesthetics interfere with the polarization of developing cortical neurons
J Neurosurg Anesthesiol. 2012 Oct;24(4):368-75. Mintz CD, Smith SC, Barrett KM, Benson DL.
Isoflurane-induced apoptosis of oligodendrocytes in the neonatal primate brain
Ann Neurol. 2012 Oct;72(4):525-35. Brambrink AM, Back SA, Riddle A, Gong X, Moravec MD, Dissen GA, Creeley CE, Dikranian KT, Olney JW.
Report of the third PANDA symposium on “Anesthesia and Neurodevelopment in Children”
J Neurosurg Anesthesiol. 2012 Oct;24(4):357-61. Miller TL, Park R, Sun LS.
Feasibility and pilot study of the Pediatric Anesthesia NeuroDevelopment Assessment (PANDA) project
J Neurosurg Anesthesiol. 2012 Oct;24(4):382-8. Sun LS, Li G, DiMaggio CJ, Byrne MW, Ing C, Miller TL, Bellinger DC, Han S, McGowan FX.
Elective procedures and anesthesia in children: pediatric surgeons enter the dialogue on neurotoxicity questions, surgical options, and parental concerns
J Neurosurg Anesthesiol. 2012 Oct;24(4):396-400. Byrne MW, Ascherman JA, Casale P, Cowles RA, Gallin PF, Maxwell LG.
Pediatric anesthesia and neurodevelopmental impairments: a Bayesian meta-analysis
J Neurosurg Anesthesiol. 2012 Oct;24(4):376-81. DiMaggio C, Sun LS, Ing C, Li G.
Anesthesia-Induced Developmental Neurodegeneration: The Role of Neuronal Organelles
Front Neurol. 2012; 3: 141. Published online 2012 October 11. doi: 10.3389/fneur.2012.00141 Vesna Jevtovic-Todorovic, A. Boscolo, V. Sanchez, N. Lunardi
Advanced pre-clinical research approaches and models to studying pediatric anesthetic neurotoxicity
Front Neurol. 2012;3:142. doi: 10.3389/fneur.2012.00142. Epub 2012 Oct 17. Wang C.
SmartTots: A Public-Private Partnership Between the United States Food and Drug Administration (FDA) and the International Anesthesia Research Society (IARS)
Paediatr Anaesth. 2012 Oct;22(10):969-72. Ramsay JG, Roizen M, Davidson A
September
Anesthesiology. 2012 Sep 20. [Epub ahead of print] Sall JW, Stratmann G, Leong J, Woodward E, Bickler PE
Neonatal Exposure to Sevoflurane Causes Apoptosis and Reduces nNOS Protein Expression in Rat Hippocampus
Mol Med Report. 2012 Sep;6(3):543-6. doi: 10.3892/mmr.2012.976. Epub 2012 Jul 2. Zhou X, Song FH, He W, Yang XY, Zhou ZB, Feng X, Zhou LH.
Are Anesthesia and Surgery during Infancy Associated with Altered Academic Performance during Childhood?
Anesthesiology. 2012 Sep;117(3):494-503. Block RI, Thomas JJ, Bayman EO, Choi JY, Kimble KK, Todd MM.
Long-term Differences in Language and Cognitive Function After Childhood Exposure to Anesthesia Pediatrics. 2012 Sep;130(3):e476-85. Ing C, Dimaggio C, Whitehouse A, Hegarty MK, Brady J, von Ungern-Sternberg BS, Davidson A, Wood AJ, Li G, Sun LS.
Review Article: Neuraxial Analgesia in Neonates and Infants: A Review of Clinical and Preclinical Strategies for the Development of Safety and Efficacy Data
Anesthesia & Analgesia. 2012 Sep;115(3):638-62. Epub 2012 Jul 13. Walker SM, Yaksh TL.
August
Vutskits L Anesthesia & Analgesia. 2012 Aug 2. [Epub ahead of print]
March
Anesthesiology. 2012 Mar;1
Delayed environmental enrichment reverses sevoflurane-induced memory impairment
Anesthesiology. 2012 Mar;1
Maternal anesthesia and fetal neurodevelopment
Int J Obstet Anesth. 2012
February
Propofol Neurotoxicity Is Mediated by p75 Neurotrophin Receptor Activation
Anesthesiology. Pearn, Matthew L. M.D.; Hu, Yue B.S.; Niesman, Ingrid R. M.S.; Patel, Hemal H. Ph.D.; Drummond, John C. M.D.; Roth, David M. Ph.D., M.D.; Akassoglou, Katerina Ph.D.; Patel, Piyush M. M.D.; Head, Brian P. M.S., Ph.D.
January
Anesthesiology. 2012 Jan 4. [Epub ahead of print] Brambrink AM, Evers AS, Avidan MS, Farber NB, Smith DJ, Martin LD, Dissen GA, Creeley CE, Olney JW.
2019 Research Articles
December
Playing with dexmedetomidine pharmacokinetics!
British Journal of Anaesthesia December 23, 2019
Dexmedetomidine improves neurodevelopment and cognitive impairment in infants with congenital heart disease
Personalized Medicine December 16, 2019
Analysis of 1478 Cases of Hypospadias Repair: The Incidence of Requiring Repeated Anesthetic Exposure as Well as Exploration of the Involvement of Trainees on Case Duration
Anesthesia & Analgesia December 9, 2019
Does general anesthesia affect neurodevelopment in infants and children?
BMJ December 9, 2019
Ketamine Regulates Phosphorylation of CRMP2 To Mediate Dendritic Spine Plasticity
Journal of Molecular Neuroscience December 5, 2019
Hemin treatment protects neonatal rats from sevoflurane-induced neurotoxicity via the phosphoinositide 3-kinase/Akt pathway
Life Sciences December 2019
November
Maternal exposure to volatile anesthetics induces IL-6 in fetal brains and affects neuronal development.
European Journal of Pharmacology November 15, 2019
Traditional Chinese medicine, Kami-Shoyo-San protects ketamine-induced neurotoxicity in human embryonic stem cell-differentiated neurons through activation of brain-derived neurotrophic factor.
NeuroReport November 6, 2019
“Pediatric Anesthetic Neurotoxicity” Time to Stop!
Anesthesia & Analgesia November 5, 2019
Neurodevelopmental Effect of General Anesthesia on the Pediatric Patient.
Journal of Pediatric Ophthalmology and Strabismus November 1, 2019
Beyond Anesthesia Toxicity: Anesthetic Considerations to Lessen the Risk of Neonatal Neurological Injury
Anesthesia & Analgesia November 2019
Dexmedetomidine pretreatment attenuates isoflurane-induced neurotoxicity via inhibiting the TLR2/NF-κB signaling pathway in neonatal rats
Experimental and Molecular Pathology November 2019
Early Postnatal Exposure to Isoflurane Disrupts Oligodendrocyte Development and Myelin Formation in the Mouse Hippocampus
Perioperative Medicine November 2019
Sirtuin 2 Inhibition Attenuates Sevoflurane-Induced Learning and Memory Deficits in Developing Rats via Modulating Microglial Activation
Cellular and Molecular Neurobiology November 2019
Using animal models to evaluate the functional consequences of anesthesia during early neurodevelopment
Neurobiology of Learning and Memory November 2019
Voluntary Exercise Rescues the Spatial Memory Deficit Associated With Early Life Isoflurane Exposure in Male Rats
Anesthesia & Analgesia November 2019
October
Should nitrous oxide ever be used in oncology patients receiving methotrexate therapy?
Pediatric Anesthesia October 31, 2019
MicroRNA-665 mediates propofol-induced cell apoptosis in human stem cell-derived neurons
Bioengineered October 26, 2019
Influence of general anesthetic exposure in developing brain on cognition and the underlying mechanisms
October 25, 2019
Sedation practices in pediatric patients with acute lymphoblastic leukemia.
Pediatric Blood & Cancer October 18, 2019
Distinct, sex-dependent miRNA signatures in piglet hippocampus induced by a clinically relevant isoflurane exposure: a pilot study.
Journal of Anesthesia October 14, 2019
General anesthetic neurotoxicity in the young: Mechanism and prevention.
Neuroscience & Biobehavioral Reviews October 10, 2019
Cognitive impairment and transcriptomic profile in hippocampus of young mice after multiple neonatal exposures to sevoflurane.
Aging October 3, 2019
Protective Effects of Xenon on Propofol-Induced Neurotoxicity in Human Neural Stem Cell-Derived Models.
Molecular Neurobiology October 2, 2019
The expression of glucose transporters and mitochondrial division and fusion proteins in rats exposed to hypoxic preconditioning to attenuate propofol neurotoxicity.
International Journal of Neuroscience October 2, 2019
Hypoxia, hypercarbia, and mortality reporting in studies of anaesthesia-related neonatal neurodevelopmental delay in rodent models: A systematic review.
European Journal of Anaesthesiology October 2019
LncRNA MALAT1 is involved in sevoflurane-induced neurotoxicity in developing rats.
Journal of Cellular Biochemistry October 2019
Maternal surgery during pregnancy has a transient adverse effect on the developing fetal rabbit brain
American Journal of Obstetrics and Gynecology October 2019
Mild hypothermia ameliorates anesthesia toxicity in the neonatal macaque brain
Neurobiology of Disease October 2019
The positive allosteric modulation of GABAA receptors mRNA in immature hippocampal rat neurons by midazolam affects receptor expression and induces apoptosis.
International Journal of Neuroscience October 2019
Xenon reduces sevoflurane-induced respiratory depression and neuro-apoptosis in immature rats
British Journal of Anaesthesia October 2019
September
British Journal of Anaesthesia September 27, 2019
Early exposure to general anesthesia impairs social and emotional development in rats.
Molecular Neurobiology September 7, 2019
Sevoflurane-Induced Dysregulation of Cation-Chloride Cotransporters NKCC1 and KCC2 in Neonatal Mouse Brain.
Molecular Neurobiology September 6, 2019
The Role of Free Oxygen Radicals in Lasting Hyperexcitability of Rat Subicular Neurons After Exposure to General Anesthesia During Brain Development.
Molecular Neurobiology September 6, 2019
Defining the Vulnerability Window of Anesthesia-Induced Neuroapoptosis in Developing Dentate Gyrus Granule Cells – A Transgenic Approach Utilizing POMC-EGFP Mice.
Neuroscience September 1, 2019
Knockdown of lncRNA MALAT1 alleviates bupivacaine-induced neurotoxicity via the miR-101-3p/PDCD4 axis.
Life Sciences September 1, 2019
Perioperative Neurocognitive Disorder
Anesthesiology September 2019
August
PLOS Biology August 21, 2019
Anesthesia-induced developmental neurotoxicity in children: past, present, and future
Chinese Medical Journal August 20, 2019
Anesthesia Neurotoxicity in the Developing Brain: Basic Studies Relevant for Neonatal or Perinatal Medicine.
Clinics in Perinatology August 14, 2019
Human Studies of Anesthesia-Related Neurotoxicity in Children: A Narrative Review of Recent Additions to the Clinical Literature.
Clinics in Perinatology August 14, 2019
Anesthetics: from modes of action to unconsciousness and neurotoxicity.
Journal of Neurophysiology August 2019
Exposure to General Anesthesia May Contribute to the Association between Cesarean Delivery and Autism Spectrum Disorder.
Journal of Autism and Developmental Disorders August 2019
Potential role of the cAMP/PKA/CREB signalling pathway in hypoxic preconditioning and effect on propofol‑induced neurotoxicity in the hippocampus of neonatal rats.
Molecular Medicine Reports August 2019
July
Frontiers in Neuroscience July 11, 2019
Overexpression of lncRNA Gm15621 alleviates apoptosis and inflammation response resulting from sevoflurane treatment through inhibiting miR-133a/Sox4.
Journal of Cellular Physiology July 2, 2019
Neonatal general anesthesia causes lasting alterations in excitatory and inhibitory synaptic transmission in the ventrobasal thalamus of adolescent female rats
Neurobiology of Disease July 2019
Parental understanding of their child’s risk of anaesthesia
British Journal of Anaesthesia July 2019
Toxicity mechanism of sevoflurane in neural stem cells of rats through DNA methylation.
Experimental and Therapeutic Medicine July 2019
June
JAMA Oncology June 20, 2019
GAS, PANDA, and MASK – No Evidence of Clinical Anesthetic Neurotoxicity!
Vutskits & Culley June 20, 2019
17β-Estradiol Treatment Attenuates Neurogenesis Damage and Improves Behavior Performance After Ketamine Exposure in Neonatal Rats.
Frontiers in Cellular Neuroscience June 13, 2019
Propofol induces impairment of mitochondrial biogenesis through inhibiting the expression of peroxisome proliferator-activated receptor-γ coactivator-1α
Journal of Cellular Biochemistry June 12, 2019
Both GSK-3β/CRMP2 and CDK5/CRMP2 pathways participate in the protection of dexmedetomidine against propofol-induced learning and memory impairment in neonatal rats.
Toxicological Sciences June 10, 2019
The Effects of Anesthesia on the Pediatric Developing Brain: Strategies to Reduce Anesthesia Use in Pediatric MRI and Nursing’s Role in Driving Patient Safety
Journal of PeriAnesthesia Nursing June 10, 2019
Anesthesia Exposure in the Young Child and Long-term Cognition: An Integrated Review.
AANA Journal June 2019
Euxanthone Ameliorates Sevoflurane-Induced Neurotoxicity in Neonatal Mice.
Journal of Molecular Neuroscience June 2019
Mayo Anesthesia Safety in Kids continued: two new studies and a potential redirection of the field
British Journal of Anaesthesia June 2019
May
Frontiers in Neuroscience May 28, 2019
microRNA‐124 attenuates isoflurane‐induced neurological deficits in neonatal rats via binding to EGR1
Journal of Cellular Physiology May 27, 2019
Cell cycle activation contributes to isoflurane-induced neurotoxicity in the developing brain and the protective effect of CR8.
CNS Neuroscience & Therapeutics May 25, 2019
Neonatal exposure to the experimental environment or ketamine can induce long-term learning dysfunction or overmyelination in female but not male rats.
NeuroReport May 1, 2019
Disrupted folate metabolism with anesthesia leads to myelination deficits mediated by epigenetic regulation of ERMN
EBioMedicine May 2019
Limb Remote Ischemic Preconditioning Reduces Repeated Ketamine Exposure-Induced Adverse Effects in the Developing Brain of Rats
Journal of Molecular Neuroscience May 2019
Patterns of neuropsychological changes after general anaesthesia in young children: secondary analysis of the Mayo Anesthesia Safety in Kids study
British Journal of Anaesthesia May 2019
Pre-administration of luteoline attenuates neonatal sevoflurane-induced neurotoxicity in mice.
Acta Histochemica May 2019
April
Journal of American Association for Pediatric Ophthalmology and Strabismus April 14, 2019
Combined spinal/caudal catheter anesthesia: extending the boundaries of regional anesthesia for complex pediatric urological surgery
Journal of Pediatric Urology April 11, 2019
Dexmedetomidine reduced sevoflurane-induced neurodegeneration and long-term memory deficits in neonatal rats
International Journal of Developmental Neuroscience April 5, 2019
Erythropoietin Reduces Neurodegeneration and Long-Term Memory Deficits Following Sevoflurane Exposure in Neonatal Rats
Neurotoxicity Research April 5, 2019
Quantitative ultrasound and apoptotic death in the neonatal primate brain
Neurobiology of Disease April 2, 2019
Assessing Long-term Neurodevelopmental Outcome Following General Anesthesia in Early Childhood: Challenges and Opportunities
Anesthesia & Analgesia April 2019
Caudal epidural blocks in paediatric patients: a review and practical considerations
British Journal of Anaesthesia April 2019
Female rats are more vulnerable to lasting cognitive impairment after isoflurane exposure on postnatal day 4 than 7
British Journal of Anaesthesia April 2019
Lasting effects of general anesthetics on the brain in the young and elderly: “mixed picture” of neurotoxicity, neuroprotection and cognitive impairment.
Journal of Anesthesia April 2019
Neuroinflammation in the Developing Brain: Risk Factors, Involvement of Microglial Cells, and Implication for Early Anesthesia
Anesthesia & Analgesia April 2019
Performance on the Operant Test Battery in young children exposed to procedures requiring general anaesthesia: the MASK study
British Journal of Anaesthesia April 2019
March
PLOS One March 21, 2019
Anaesthetic neuroprotection in children: does it exist or is it all just bad?
Current Opinion in Anesthesiology March 2019
Effects of non-obstetric surgery under ketamine anaesthesia in the middle stage of pregnancy on cognition in the offspring and underlying mechanisms
British Journal of Anaesthesia March 2019
Sevoflurane-induced learning deficits and spine loss via nectin-1/corticotrophin-releasing hormone receptor type 1 signalling in neonatal mice
British Journal of Anaesthesia March 2019
February
Bosnian Journal of Basic Medical Sciences February 26, 2019
Effects of Perinatal Exposure to Ketamine on the Developing Brain
Frontiers in Neuroscience February 22, 2019
Dexmedetomidine attenuates the neurotoxicity of propofol toward primary hippocampal neurons in vitro via Erk1/2/CREB/BDNF signaling pathways
Drug Design, Development and Therapy February 19, 2019
Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised, controlled equivalence trial
The Lancet. February 16, 2019
Neurodevelopment after general anaesthesia in infants
The Lancet. February 16, 2019
Inhibition of microRNA-375 ameliorated ketamine-induced neurotoxicity in human embryonic stem cell derived neurons.
European Journal of Pharmacology February 5, 2019
Fundamentals of fetal toxicity relevant to sevoflurane exposures during pregnancy.
International Journal of Developmental Neuroscience. February 2019
Neonatal exposure to propofol affects interneuron development in the piriform cortex and causes neurobehavioral deficits in adult mice.
Psychopharmacology February 2019
January
Brazilian Journal of Anesthesiology. January – February 2019
Neurotoxicity of anesthetics: Mechanisms and meaning from mouse intervention studies
Neurotoxicology and Teratology January – February 2019
Neurotoxicity of general anesthetics in children: evidence and uncertainties.
Current Opinion in Pediatrics January 31, 2019
Juvenile Rats Show Altered Gut Microbiota After Exposure to Isoflurane as Neonates
Neurochemical Research January 2, 2019
Astragaloside suppresses tumor necrosis factor receptor-associated factor 5 signaling pathway and alleviates neurodegenerative changes in retinal pigment epithelial cells induced by isoflurane.
Journal of Cellular Biochemistry January 2019
A Review of Clinical Poster Presentations at the Sixth Biennial Pediatric Anesthesia Neurodevelopment Assessment (PANDA) Symposium
Journal of Neurosurgical Anesthesiology January 2019
An Open Label Pilot Study of a Dexmedetomidine-Remifentanil-Caudal Anesthetic for Infant Lower Abdominal/Lower Extremity Surgery: The T REX Pilot Study.
Pediatric Anesthesia. January 2019
Anesthesia and Neurodevelopment in Children: Many Important Questions Remain Unanswered
Journal of Neurosurgical Anesthesiology January 2019
Anesthesia Exposure in Children, Practitioners Respond to the 2016 FDA Drug Safety Communication
Journal of Neurosurgical Anesthesiology January 2019
Developmental Neurotoxicity: An Update
Journal of Neurosurgical Anesthesiology January 2019
Early Developmental Exposure to Repetitive Long Duration of Midazolam Sedation Causes Behavioral and Synaptic Alterations in a Rodent Model of Neurodevelopment
Journal of Neurosurgical Anesthesiology January 2019
Engaging Stakeholders to Promote Safe Anesthesia and Sedation Care in Young Children
Journal of Neurosurgical Anesthesiology January 2019
Epidemiology and Resource Utilization of Simple Febrile Seizure-associated Hospitalizations in the United States, 2003-2012
Journal of Neurosurgical Anesthesiology January 2019
Introduction to “Anesthesia and Neurodevelopment in Children”: A Supplement from the Sixth Pediatric Anesthesia Neurodevelopmental Assessment (PANDA) Symposium
Journal of Neurosurgical Anesthesiology January 2019
Outcomes Research in Vulnerable Pediatric Populations
Journal of Neurosurgical Anesthesiology January 2019
Prolonged Anesthetic Exposure in Children and Factors Associated With Exposure Duration
Journal of Neurosurgical Anesthesiology January 2019
Reaching Parents Through an Online Community
Journal of Neurosurgical Anesthesiology January 2019
Report on the Sixth Pediatric Anesthesia Neurodevelopmental Assessment (PANDA) Symposium, “Anesthesia and Neurodevelopment in Children.”
Journal of Neurosurgical Anesthesiology January 2019
SmartTots Outcomes Workshop 2017: Notes From a Round Table Discussion About Outcome Measures
Journal of Neurosurgical Anesthesiology January 2019
Summary of Preclinical Poster Presentations at the Sixth Biennial Pediatric Anesthesia Neurodevelopment Assessment (PANDA) Symposium
Journal of Neurosurgical Anesthesiology January 2019
The association between attention deficit hyperactivity disorder and general anaesthesia – a narrative review
Anaesthesia January 2019
Using Neuroimaging to Study the Effects of Pain, Analgesia, and Anesthesia on Brain Development
Journal of Neurosurgical Anesthesiology January 2019
2017 Research Articles
December
BMC Anesthesiology. December 19, 2017
Effects of short-term exposure to sevoflurane on the survival, proliferation, apoptosis, and differentiation of neural precursor cells derived from human embryonic stem cells.
Journal of Anesthesia. December 2017
More than 3 hours and less than 3 years: Safety of anaesthetic procedures in infants less than 3 years old subjected to surgery for more the 3 hours
Anales de Pediatría December 2017
Pediatric Anesthesia Considerations for Interventional Radiology
Anesthesiology December 2017
Challenges in the anesthetic management of ambulatory patients in the MRI suites
Current Opinion in Anestiology December 2017
Xenon as an adjuvant to sevoflurane anesthesia in children younger than 4 years of age, undergoing interventional or diagnostic cardiac catheterization: A randomized controlled clinical trial
Paediatric anaesthesia December 2017
Caffeine combined with sedative/anesthetic drugs triggers widespread neuroapoptosis in a mouse model of prematurity
The Journal of Maternal-Fetal & Neonatal Medicine December 2017
Hydrogen gas attenuates sevoflurane neurotoxicity through inhibiting nuclear factor κ-light-chain-enhancer of activated B cells signaling and proinflammatory cytokine release in neonatal rats
NeuroRepprt December 6, 2017
Protective effects of a green tea polyphenol, epigallocatechin-3-gallate, against sevoflurane-induced neuronal apoptosis involve regulation of CREB/BDNF/TrkB and PI3K/Akt/mTOR signaling pathways in neonatal mice
Canadian Journal of Physiology and Pharmacology 2017 Dec
Exposure of Developing Brain to General Anesthesia: What Is the Animal Evidence?
Anesthesiology. 2017 Dec 22
November
Frontiers in Cellular Neuroscience. November 22, 2017
Systematic review of the neurocognitive outcomes used in studies of paediatric anaesthesia neurotoxicity.
British Journal of Anaesthesia. November 21, 2017
Effect of repeated neonatal sevoflurane exposure on the learning, memory and synaptic plasticity at juvenile and adult age.
American Journal of Translational Research. November 15, 2017
Repeated 2% sevoflurane administration in 7‑ and 60-day-old rats : Neurotoxicity and neurocognitive dysfunction.
Der Anaesthesist. November 2017
Caffeine combined with sedative/anesthetic drugs triggers widespread neuroapoptosis in a mouse model of prematurity
The Journal of Maternal-Fetal & Neonatal Medicine November 2017
Predictors of Anesthetic Duration in Common Pediatric General Surgical Procedures
Anesthesioligy Today
Isoflurane exposure regulates the cell viability and BDNF expression of astrocytes via upregulation of TREK‑1
Mol Med Rep. 2017 Nov
Subsequent maternal separation exacerbates neurobehavioral abnormalities in rats neonatally exposed to sevoflurane anesthesia
Neuroscience Letters 20 November 2017
October
American Society of Anesthesiologists. October 21, 2017
Perinatal and neonatal use of sedation and analgesia
sfnm journal. October 7, 2017
Non-Anaesthetic Effects of Volatile Anaesthetics: A Short Trip on the Sea of Translational Medicine
October 2017
Sedation Analgesia and Neuromuscular Blockade in Pediatric Critical Care: Overview and Current Landscape.
Pediatric Clinics of North America. October 2017
September
Clinical Anesthesiology September 5, 2017
Reproducibility of science and developmental anaesthesia neurotoxicity: a tale of two cities.
British Journal of Anaesthesia. September 2017
August
Neurotox Res.2017 Apr 24
Are Anesthesia and Surgery during Infancy Associated with Decreased White Matter Integrity and Volume During Childhood?
Anesthesiology Newly August 24, 2017
Editorial: Can We Really Suggest that Anesthesia Might Cause Attention-deficit/Hyperactivity Disorder?
Anesthesiology, August 2017
Association between Exposure of Young Children to Procedures Requiring General Anesthesia and Learning and Behavioral Outcomes in a Population-based Birth Cohort
Anesthesiology, August 2017
Overexpression cdc42 attenuates isoflurane-induced neurotoxicity in developmental brain of rats
Biochemical and Biophysical Research Communications 26 August 2017
Neonatal Propofol Anesthesia Changes Expression of Synaptic Plasticity Proteins and Increases Stereotypic and Anxyolitic Behavior in Adult Rats
Neurotox Res. 2017 Aug
July
Psychoneuroendocrinology. July 2017
Latent Class Analysis of Neurodevelopmental Deficit After Exposure to Anesthesia in Early Childhood
Journal of Neurosurgical Anesthesiology. July 2017
Insufficient Astrocyte-Derived Brain-Derived Neurotrophic Factor Contributes to Propofol-Induced Neuron Death through Akt/Glycogen Synthase Kinase 3β/Mitochondrial Fission Pathway
Anesthesia & Analgesia. July 2017
EDITORIAL Reducing risk in pediatric anesthesia: What are the implications from the APRICOT study?
Pediatric Anesthesia July 2017
June
Current Opinion in Anaesthesiology. June 30, 2017
Propofol-induced downregulation of NR2B membrane translocation in hippocampus and spatial memory deficits of neonatal mice
Brain Behav. June 2, 2017
May
Journal of the American College of Surgeons. May 2017
Rutin attenuates isoflurane-induced neuroapoptosis via modulating JNK and p38 MAPK pathways in the hippocampi of neonatal rats
Exp Ther Med. 2017 May
Can we reduce anesthesia exposure? Neonatal brain MRI: Swaddling vs. sedation, a national survey
JOURNAL OF CLINICAL ANESTHESIA May 2017
Optimization of Pediatric PET/CT
Semin Nucl Med. 2017 May
Visual recognition memory is impaired in rhesus monkeys repeatedly exposed to sevoflurane in infancy
Br J Anaesth aew473 31 May 2017
April
Dermatol Surg. 2017 Apr
Elamipretide (SS-31) Ameliorates Isoflurane-Induced Long-Term Impairments of Mitochondrial Morphogenesis and Cognition in Developing Rats
Front Cell Neurosci 2017 Apr 25
March
SCIENTIFIC AMERICAN March 2017
Editorial: The new FDA drug safety communication on the use of general anesthetics in young children: what should we make of it?
Pediatric Anesthesia 16 MAR 17
Why Some Pediatric Neurologists Are Concerned About a New FDA Warning About Anesthesia
Neurologists Today 16 March 2017
February
Oncotarget. February 7, 2017
Anesthesia, Brain Changes, and Behavior: Insights from Neural Systems Biology
ScieceDirect 8 February 2017
Letter to the Editor: Was isoflurane the only cause of IL-1β upregulation?
Journal of Anesthesia 16 February 2017
Anesthetic-Related Neurotoxicity and Neuroimaging in Children: A Call for Conversation
Journal of Child Neurology
Scoping review: Awareness of neurotoxicity from anesthesia in children in otolaryngology literature
Laryngoscope 2017 Feb 22
Anesthesia and Developing Brains—Implications of the FDA Warning
N Engl J Med 2017
Introduction to the special issue “Developmental neurotoxicity associated with pediatric general anesthesia: Preclinical findings”
Neurotoxicology and Teratology 2017.02.01
January
Neurotoxicol Teratol. 2017 Jan 6
Selective induction of IL-1β after a brief isoflurane anesthetic in children undergoing MRI examination
J Anesth. 2017 Jan 3
Current thinking regarding potential neurotoxicity of general anesthesia in infants
Curr Opin Urol. 2017 Jan;27
The Neurotoxicity of General Anesthetic Drugs: Emphasis on the Extremes of Age Annu Rev Nurs Res. 2017 Jan 3
2015 Research Articles
December
HealthDay News, December 15, 2015
November
Pediatric Anesthesia, Ward CG, Hines SJ, Maxwell LG, McGowan FX, Sun LS.
October
Presented at ASA, October 27, 2015
Dexmedetomidine Mitigates Neuroapoptosis Induced by Prenatal Intravenous Anesthetic Exposure in Rats
Presented at ASA, October 26, 2015
Latent Class Analysis of Neuropsychological Deficit After Exposure to Anesthesia in Early Childhood
Presented as ASA, October 26, 2015
Identifying Children at Risk for Anesthetic Neurotoxicity
Presented as ASA,October 24, 2015
Development of a Translational, Preclinical Piglet Model of Anesthesia-Induced Neurotoxicity Mechanisms in the Pediatric Population
Presented at ASA, October 24, 2015
Estimation and Analysis of Unnecessarily Early Procedures in Infants Younger than Six Month of Age in the United States
Presented at ASA, October 24, 2015
Neonatal MRI: Can We Reduce Anesthesia Exposure? A National Survey
Presented at ASA, October 24, 2015
Sedation and analgesia practices in neonatal intensive care units (EUROPAIN): results from a prospective cohort study
The Lancet, October 2015
September
Korean J Anesthesiol. 2015 Oct; 68(5): 434–441.
Published online 2015 Sep 30.
August
Int J Clin Exp Med. 2015; 8(8): 14397–14409.
Published online 2015 Aug 15.
Pediatric dental sedation: challenges and opportunities
Clin Cosmet Investig Dent. 2015; 7: 97–106.
Published online 2015 Aug 26.
July
Behavioral Neuroscience, Vol 129(5),
Craig, M. M., & Bajic, D. (2015, July 27).
Long-term action of propofol on cognitive function and hippocampal neuroapoptosis in neonatal rats
Int J Clin Exp Med. 2015; 8(7): 10696–10704.
Published online 2015 Jul 15.
Neuroprotective properties of vitamin C on equipotent anesthetic concentrations of desflurane, isoflurane, or sevoflurane in high fat diet fed neonatal mice
Int J Clin Exp Med. 2015; 8(7): 10444–10458.
Published online 2015 Jul 15.
Anesthetic use in newborn infants: the urgent need for rigorous evaluation
Pediatr Res. 2015 Jul; 78(1): 2–6.
Published online 2015 Apr 8.
Cognition and Brain Structure Following Early Childhood Surgery With Anesthesia
Pediatrics, June 2015
Barynia Backeljauw, Scott K. Holland, Mekibib Altaye, Andreas W. Loepke
Propofol: A Review of its Role in Pediatric Anesthesia and Sedation
CNS Drugs, July 2015, Volume 29, Issue 7, pp 543-563
Age-dependent electroencephalogram (EEG) patterns during sevoflurane general anesthesia in infants
eLIFE, July 2015
Age-dependency of sevoflurane-induced electroencephalogram dynamics in children
British Journal of Anaesthesia, 2015
June
Pediatrics, June 2015.
Backeljawu B, Holland SK, Altaye M, Loepke AW
microRNA Expression Profiling of Propofol-Treated Developing Rat Hippocampal
DNA Cell Biol, June 2015.
Sun W, Pei L
Regional (spinal, epidural, caudal) versus general anaesthesia in preterm infants undergoing inguinal herniorrhaphy in early infancy
Cochrane Database Syst Rev., June 2015.
Jones LJ, Craven PD, Lakkundi A, Foster JP, Badawi N
Ketamine-Induced Toxicity in Neurons Differentiated from Neural Stem Cells
Mol Neurobiol, June 2015.
Slikker W Jr, Liu F, Rainosek SW, Patterson TA, Sadovova N, Hanig JP, Paule MG, Wang C
Early Exposure to General Anesthesia Disrupts Spatial Organization of Presynaptic Vesicles in Nerve Terminals of the Developing Rat Subiculum
Mol Neurobiol, June 2015.
Lunardi N, Oklopcic A, Prillaman M, Erisir A, Jevtovic-Todorovic V.
Long-term NMDA receptor inhibition affects NMDA receptor expression and alters glutamatergic activity in developing rat hippocampal neurons
Toxicology, June 2015.
Sinner B, Friedrich O, Lindner R, Bundscherer A, Graf BM
Anesthesia-related critical incidents in the perioperative period in children; a proposal for an anesthesia-related reporting system for critical incidents in children
Paediatr Anaesth, June 2015.
De Graaff JC, Sarfo MC, van Wolfswinkel L, van der Werff DB, Schouten AN
Safe Anesthesia For Every Tot – The SAFETOTS initiative.
Curr Opin Anaesthesiol, June 2015. Weiss M, Vutskits L, Hansen TG, Engelhardt T
Surgical Anesthesia in Young Children Linked to Effects on IQ, Brain Structure
Cincinnati Surgical, June 08, 2015
May
Free Radic Biol Med.2015 May 29. pii: S0891-5849(15)00252-X. doi: 10.1016/j.freeradbiomed.2015.05.029. [Epub ahead of print] Cheng Y1, Mitchell-Flack MJ2, Wang A<2, Levy RJ
Apnea after Awake Regional and General Anesthesia in Infants: The General Anesthesia Compared to Spinal Anesthesia Study-Comparing Apnea and Neurodevelopmental Outcomes, A Randomized Controlled Trial
Anesthesiology, May 2015. Davidson AJ, Morton NS, Arnup SJ, de Graaff JC, Disma N, Withington DE, Frawley G, Hunt RW, Hardy P, Khotcholava M, von Ungern Sternberg BS, Wilton N, Tuo P, Salvo I, Ormond G, Stargatt R, Locatelli BG, McCann ME
Predictors of Failure of Awake Regional Anesthesia for Neonatal Hernia Repair: Data from the General Anesthesia Compared to Spinal Anesthesia Study-Comparing Apnea and Neurodevelopmental Outcomes. Anesthesiology. 2015 May 14. Frawley G1, Bell G, Disma N, Withington DE, de Graaff JC, Morton NS, McCann ME, Arnup SJ, Bagshaw O, Wolfler A, Bellinger D, Davidson AJ; General Anesthesia compared to Spinal anesthesia (GAS) Consortium.
Is this your (paediatric patient’s) brain on (anaesthetic) drugs?: The search for a potential neurological phenotype of anaesthesia-related neurotoxicity in humans
European Journal of Anaesthesiology, May 2015. Loepke AW, Hansen TG.<
Risk of autistic disorder after exposure to general anaesthesia and surgery: A nationwide, retrospective matched cohort study
European Journal of Anaesthesiology, May 2015. Ko WR, Huang JY, Chiang YC, Nfor ON, Ko PC, Jan SR, Lung CC, Chang HC, Lin LY, Liaw YP
Anesthesia and the developing brain: a way forward for clinical research.
Paediatr Anaesth, May 2015. Davidson AJ, Becke K, de Graff J, Giribaldi G, Habre W, Hansen T, Hunt RW, Ing C, Loepke A, McCann ME, Ormond GD, Pini Prato A, Salvo I, Sun L, Vutskits L, Walker S, Disma N.
Impact of propofol anaesthesia on cytokine expression profiles in the developing rat brain: A randomised placebo-controlled experimental in-vivo study
Eur J Anaesthesiol, May 2015. Kargaran P, Lenglet S, Montecucco F, Mach F, Copin JC, Vutskits L
Regional anaesthesia in neonates, infants and children: An educational review
European Journal of Anaesthesiology, May 2015. Martin J
Elevation of Sestrin-2 expression attenuates Sevoflurane induced neurotoxicity
Metab Brain Dis, May 2015. Yi W, Zhang Y, Guo Y, Li D, Li X
April
Dexmedetomidine Attenuates Neurotoxicity Induced by Prenatal Propofol Exposure.
J Neurosurg Anesthesiol, April 2015.
Li J, Xiong M, Nadavaluru PR, Zuo W, Ye JH, Eloy JD, Bekker A.
Repeated Exposure to Ketamine-Xylazine during Early Development Impairs Motor Learning-dependent Dendritic Spine Plasticity in Adulthood
Anesthesiology, April 2015. Huang L, Yang G
Neurodevelopmental implications of the general anesthesia in neonate and infants
Exp Neurol, April 2015.
Lee JH, Zhang J, Wei L, Yu SP
Neurotoxicity of Generic Anesthesia Agents in Infants and Children: An Orphan Research Question in Search of a Sponsor
JAMA, April 2015. Psaty BM, Platt R, Altman RB
Low-dose sevoflurane promotes hippocampal neurogenesis and facilitates the development of dentate gyrus-dependent learning in neonatal rats.
ASN Neuro. April 2015. Chen C, Shen FY, Zhao X, Zhou T, Xu DJ, Wang ZR, Wang YW
Perioperative effects of caudal and transversus abdominis plane (TAP) blocks for children undergoing urologic robot-assisted laparoscopic surgery.
J Pediatr Urol, April 2015. Faasse MA, Lindgren BW, Frainey BT, Marcus CR, Szczodry DM, Glaser AP, Suresh S, Gong EM
Developmental stage-dependent impact of midazolam on calbindin, calretinin and parvalbumin expression in the immature rat medial prefrontal cortex during the brain growth spurt.
Int J Dev Neurosci, April 2015. Osterop SF, Virtanen MA, Loepke JR, Joseph B, Loepke AW, Vutskits L
Surgical Injury in the Neonatal Rat Alters the Adult Pattern of Descending Modulation from the Rostroventral Medulla
Anesthesiology. 2015 Apr 13. Walker SM, Fitzgerald M, Hathway GJ
Neurosurgical conditions and procedures in infancy are associated with mortality and academic performances in adolescence: a nationwide cohort study
Paediatr Anaesth, February 2015. Hansen TG, Pedersen JK, Henneberg SW, Morton NS, Christensen K
March
A comparison of functional magnetic resonance imaging findings in children with and without a history of early exposure to general anesthesia
Paediatr Anaesth, March 2015.
Pre-treatment with a Xingnaojing preparation ameliorates sevoflurane-induced neuroapoptosis in the infant rat striatum.
Mol Med Rep, March 2015.
Effect of apoptosis in neural stem cells treated with sevoflurane
BioMed Central Anesthesiology, 2015.
Neuroprotective effects of pterostilbene against isoflurane-induced apoptosis through regulating the JNK and PI3K/Akt pathway in neonatal rats
Bangladesh Journal of Pharmacology, 2015.
Repeated Exposure to Ketamine-Xylazine during Early Development Impairs Motor Learning-dependent Dendritic Spine Plasticity in Adulthood
Anesthesiology, 2015.
Interventional Procedures for Chronic Pain in Children and Adolescents: A Review of the Current Evidence
Pain Pract, March 2015.
Shah RD, Cappiello D, Suresh S
February
Dexamethasone but not the equivalent doses of hydrocortisone induces neurotoxicity in neonatal rat brain.
Pediatr Res, February 2015.
Is There Evidence for Long-Term Neurocognitive Effects of Sedatives
Pediatric Sedation Outside of the Operating Room: A Multispecialty International Collaboration, 2015.
Special aspects of pediatric anesthesia in ophthalmic surgery
Ophthalmologe, February 2015. Keilhauer J, Trieschmann U, Böttiger BW
Morphological features of the neonatal brain following exposure to regional anesthesia during labor and delivery
Magnetic Resonance Imagning, February, 2015
Anesthetic neurotoxicity–clinical implications of animal models
N Engl J Med, February 2015.
January
The Journal of Neuroscience, January 2015.
Molecular pathways of mitochondrial dysfunctions: Possible cause of cell death in anesthesia-induced developmental neurotoxicity.
Brain Res Bull, January 2015.
Pre-administration of curcumin prevents neonatal sevoflurane exposure-induced neurobehavioral abnormalities in mice
Neurotoxicology, January 2015.
Ji MH, Qiu LL, Yang JJ, Zhang H, Sun XR, Zhu SH, Li WY, Yang JJ
Single sevoflurane exposure increases methyl-CpG island binding protein 2 phosphorylation in the hippocampus of developing mice
Mol Med Rep, January 2015.
Han XD, Li M, Zhang XG, Xue ZG, Cang J
Long-term effects of single or multiple neonatal sevoflurane exposures on rat hippocampal ultrastructure
Anesthesiology, January 2015.
Amrock LG, Starner ML, Murphy KL, Baxter MG
2013 Research Articles
December
Curr Opin Anaesthesiol, December 2013.
Do we actually need to anesthetize the neonate?
Pediatric Anesthesia, December 2013.
Early life exposure to sevoflurane impairs adulthood spatial memory in the rat
Neurotoxicology, December 2013.
Modeling anesthetic developmental neurotoxicity using human stem cells
Semin Cardiothorac Vasc Anesth, December 2013.
Neonatal exposure to sevoflurane causes significant suppression of hippocampal long-term potentiation in postgrowth rats.
Anesth Analg, December 2013.
November
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, Calgary, AB, Canada., November 2013.
October
Department of Anesthesia & Intensive Care, Odense University Hospital, Odense C, Denmark. [email protected], October 2013.
Functional implications of an early exposure to general anesthesia: are we changing the behavior of our children?
Mol Neurobiol, October 2013.
September
Arch Pediatr, September 2013.
August
Department of Anesthesiology and Perioperative Medicine Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Portland, OR, August 29, 2013.
July
Indian Journal of Anaesthesia, July 25, 2013.
Ketamine as Anesthetics can Damage Children’s Learning and Memory Ability
Science Codex, July 19, 2013.
Long-term effects of neonatal single or multiple isoflurane exposures on spatial memory in rats.
Department of Experimental Psychology, University of Oxford, Oxford , UK ; Glickenhaus Laboratory of Neuropsychology, Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai , New York, NY , USA., July 2013.
June
Department of Anesthesiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH; Program in Neuroscience, University of Cincinnati, Cincinnati, OH, June 2013.
May
April
British Journal of Anaesthesia, April 6, 2013.
Characterization and Quantification of Isoflurane-Induced Developmental Apoptotic Cell Death in Mouse Cerebral Cortex
Anesthesia & Analgesia, April 2013.
March
Anesthesiology, March 2013. Department of Anesthesia, ZhongShan hospital, Fudan University, Shanghai, China
February
J Anesth. 2013 Feb 6. [Epub ahead of print]Neurotoxicity of general anesthetics in childhood: does anesthesia leave its mark on premature babies, newborns and infants?
Anaesthesist, February 2013.
Repeated exposure to propofol potentiates neuroapoptosis and long-term behavioral deficits in neonatal rats.
Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan, PR China., February 2013.
January
Anesthesiology. 2013 Jan 29. [Epub ahead of print]Dual Effects of Isoflurane on Proliferation, Differentiation, and Survival in Human Neuroprogenitor Cells Anesthesiology. 2013 Jan 11. [Epub ahead of print]Sevoflurane Anesthesia in Pregnant Mice Induces Neurotoxicity in Fetal and Offspring Mice
Anesthesiology. 2013 January 9. [epub ahead of print]Selective Anesthesia-induced Neuroinflammation in Developing Mouse Brain and Cognitive Impairment
Anesthesiology. 2013 January 9. [epub ahead of print]Early Developmental Exposure to Volatile Anesthetics Causes Behavioral Defects in Caenorhabditis elegans Anesthesia & Analgesia. January 2013, 116 (1).
2011 Research Articles
December
Neurobiology of Disease. 2011 Dec 14. [Epub ahead of print] Boscolo A, Starr JA, Sanchez V, Lunardi N, Digruccio MR, Ori C, Erisir A, Trimmer P, Bennett J, Jevtovic-Todorovic V.
Protective Function of Nicotinamide Against Ketamine-induced Apoptotic Neurodegeneration in the Infant Rat Brain
Journal of Molecular Neuroscience. 2011 Dec 8. [Epub ahead of print] Ullah N, Ullah I, Lee HY, Naseer MI, Seok PM, Ahmed J, Kim MO.
November
Anesthesia & Analgesia Joss Thomas, Gregory Crosby, John C. Drummond, Michael Todd
Early Childhood Exposure to Anesthesia and Risk of Developmental and Behavioral Disorders in a Sibling Birth Cohort
Anesthesia & Analgesia Dimaggio C, Sun L, Li G
Pediatric Anesthesia Neurotoxicity: An Overview of the 2011 SmartTots Panel
Anesthesia & Analgesia Jevtovic-Todorovic V
SmartTots: A Multidisciplinary Effort to Determine Anesthetic Safety in Young Children
Anesthesia & Analgesia Ramsay JG, Rappaport BA
The Role of Calcium Dysregulation in Anesthetic-Mediated Neurotoxicity
Anesthesia & Analgesia Wei H
The Toxic Effects of S(+)-Ketamine on Differentiating Neurons In Vitro as a Consequence of Suppressed Neuronal Ca2+ Oscillations
Anesthesia & Analgesia Sinner B, Friedrich O, Zink W, Zausig Y, Graf BM
October
Pharmacological Research [Epub ahead of print] Ward CG, Loepke AW
Cognitive and Behavioral Outcomes After Early Exposure to Anesthesia and Surgery
Pediatrics. [Epub adhead of print] Flick RP, Katusic SK, Colligan RC, Wilder RT, Voigt RG, Olson MD, Sprung J, Weaver AL, Schroeder DR, Warner DO
September
Paediatric Drugs [Epub ahead of print] Vutskits L
Neurotoxicity of Anesthetic Drugs in the Developing Brain
Anesthesia & Analgesia [Epub ahead of print] Stratmann G
Neonatal Desflurane Exposure Induces More Robust Neuroapoptosis than Do Isoflurane and Sevoflurane and Impairs Working Memory
Anesthesiology [Epub ahead of print] Kodama M, Satoh Y, Otsubo Y, Araki Y, Yonamine R, Masui K, Kazama T
GABAergic Excitotoxicity Injury of the Immature Hippocampal Pyramidal Neurons’ Exposure to Isoflurane Anesthesia & Analgesia [Epub ahead of print] Zhao YL, Xiang Q, Shi QY, Li SY, Tan L, Wang JT, Jin XG, Luo AL
General Anesthesia Causes Long-term Impairment of Mitochondrial Morphogenesis and Synaptic Transmission in Developing Rat Brain
Anesthesiology [Epub ahead of print] Sanchez V, Feinstein SD, Lunardi N, Joksovic PM, Boscolo A, Todorovic SM, Jevtovic-Todorovic V
August
Current Opinion in Anesthesiology Jevtovic-Todorovic V
Developmental Stage-dependent persistent impact of propofol anesthesia on dendritic spines in the rat medial prefrontal cortex
Anesthesiology Briner A, Nikonenko I, De Roo M, Dayer A, Muller D, Vutskits L
Propofol induces neuronal apoptosis in infant rat brain under hypoxic conditions
Brain Research Bulletin Tu S, Wang X, Yang F, Chen B, Wu S, He W, Yuan X, Zhang H, Chen P, Wei G
July
British Journal of Anaesthesia Hudson AE, Hemmings HC Jr
Disruption of blastomeric F-actin: a potential early biomarker of developmental toxicity in zebrafish Molecular and Cellular Biochemistry Kanungo J, Paule MG
June
Anesthesia & Analgesia Flick RP, Lee K, Hofer RE et al.
Inhalation anesthetic-induced neuronal damage in the developing rhesus monkey
Neurotoxicology and Teratology Zuo X, Liu F, Zhang X et al.
Learning disability in children as an outcome in anesthesia and analgesia research
Anesthesia & Analgesia Radcliffe J, Bellinger DC
Developmental stage-dependent persistent impact of propofol anesthesia dendritic spines in the rat medial prefontal cortex
Anesthesiology Briner A, Nikonenko I, De Roo M, Dayer A, Muller D, Vutskits L
Labor analgesia and the developing human brain
Anesthesia & Analgesia Sun LS
May
FDA considers data on potential risks of anesthesia use in infants, children
The Journal of the American Medical Association Kuehn BM
April
The New England Journal of Medicine Rappaport B, Mellon RD, Simone A, Woodcock J
Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeys Neurotoxicology and Teratology Paule MG, Li M et al.
2009 Research Articles
May
Anesthesiology, May 2009.