January 2013

Request for Applications Update

SmartTots will begin accepting applications for its second round of research grants in early February. Two $200,000 grants will be available. View the preliminary RFA.

Recent Literature

Sevoflurane Anesthesia in Pregnant Mice Induces Neurotoxicity in Fetal and Offspring Mice

Each year, over 75,000 pregnant women in the United States undergo anesthesia care. The authors set out to assess the effects of the anesthetic sevoflurane on neurotoxicity in pregnant mice and on learning and memory in fetal and offspring mice. Read more

Early Developmental Exposure to Volatile Anesthetics Causes Behavioral Defects in Caenorhabditis elegans

The authors hypothesized that exposing the nematode (C. elegans) to volatile anesthetics early in life would induce neuron cell death, producing a behavioral defect that would be manifested in adulthood. Read more

Selective Anesthesia-induced Neuroinflammation in Developing Mouse Brain and Cognitive Impairment

The authors have established an animal model with single versus multiple exposures of anesthetic(s) in young versus adult mice, aiming to distinguish the role of different types of anesthesia in cognitive impairment. Read more

Repeated Exposure to Propofol Potentiates Neuroapoptosis and Long-term Behavioral Deficits in Neonatal Rats

The authors investigated the effects of neonatal propofol anesthesia on neuroapoptosis and long-term spatial learning/memory functions. Read more

Perioperative Central Nervous System Injury in Neonates

Authors suggest clinicians should be cognizant of the literature and ongoing investigations on anesthetic-induced developmental neurotoxicity (AIDN), and raise awareness of the risks of both surgery and anesthesia. Read more

Upcoming Events

SPA/AAP Pediatric Anesthesiology 2013

March 14-17, 2013 | Red Rock Resort, Las Vegas, NV
Visit SmartTots at booth #100 in the exhibit hall!

IARS 2013 Annual Meeting

May 4-7, 2013 | Sheraton Hotel & Marina, San Diego, CA
Related Sessions

  • SmartTots Panel: Update on New Scientific Advances in Anesthetic Neurotoxicity in the Developing Brain
  • Anesthesia Patient Safety Foundation (APSF) Panel
  • ISAP Panel: The Best of the New in Clinical Pharmacology