by SmartTots | May 1, 2023 | Preclinical Articles, Research Articles
Abstract Background: Sevoflurane is an inhalational anesthetic for the induction and maintenance of general anesthesia in pediatric surgery. However, few studies have paid attention to the multiple organ toxicity and the mechanism behind it. Methods: Inhalation...
by SmartTots | May 1, 2023 | Preclinical Articles, Research Articles
Abstract An increasing number of studies reveal the deleterious effects of isoflurane (Iso) exposure during pregnancy on offspring cognition. However, no effective therapeutic strategy for Iso-induced deleterious effects has been well developed. Angelicin exerts an...
by SmartTots | May 1, 2023 | Preclinical Articles, Research Articles
Abstract Sevoflurane (Sevo) is one of the most commonly used general anesthetics for infants and young children. We investigated whether Sevo impairs neurological functions, myelination, and cognition via the γ-aminobutyric acid A receptor (GABAAR) and...
by SmartTots | May 1, 2023 | Preclinical Articles, Research Articles
Abstract Background: The anesthetic isoflurane can cause neurotoxicity in fetuses and offspring of rats, affecting their neurodevelopment. However, the underlying mechanisms and therapeutic targets of isoflurane-induced neurotoxicity remain to be identified....
by SmartTots | May 1, 2023 | Preclinical Articles, Research Articles
Abstract Background: Prolonged exposure to general anesthetics during development is known to cause neurobehavioral abnormalities, but the cellular and molecular mechanisms involved are unclear. Microglia are the resident immune cells in the central nervous system and...
by SmartTots | May 1, 2023 | Preclinical Articles, Research Articles
Abstract With the advancement of technology, increasingly many newborns are receiving general anesthesia at a young age for surgery, other interventions, or clinical assessment. Anesthetics cause neurotoxicity and apoptosis of nerve cells, leading to memory and...
