by SmartTots | Jan 14, 2020 | Research Articles
Abstract Ample evidence has surfaced documenting the neurotoxic effects of various general anesthetic (GA) agents in the mammalian brain when administered at critical periods of synaptogenesis. However, little is known about how this neurotoxic insult affects...
by SmartTots | Jan 14, 2020 | Research Articles
Abstract Sedatives and anesthetics can injure the developing brain. They cause apoptosis of neurons and oligodendrocytes, impair synaptic plasticity, inhibit neurogenesis and trigger long-term neurocognitive deficits. The projected vulnerable period in humans extends...
by SmartTots | Jan 14, 2020 | Research Articles
Abstract Fifteen years ago Olney and colleagues began using animal models to evaluate the effects of anesthetic and sedative agents (ASAs) on neurodevelopment. The results from ongoing studies indicate that, under certain conditions, exposure to these drugs during...
by SmartTots | Jan 14, 2020 | Research Articles
Abstract Isoflurane anesthesia induces neuroapoptosis in the development of the brain. In this study, neonatal rats and hippocampal neurons were subjected to isoflurane exposure, in which the effect of miR‐124 on the neurological deficits induced by isoflurane was...
by SmartTots | Jan 14, 2020 | Research Articles
Abstract Aims Anaesthesia-related neurotoxicity in the developing brain is a controversial issue that has recently attracted much attention. Hemin plays a protective role in hypoxic and ischemic brain damage; however, its effects on sevoflurane-induced neurotoxicity...
by SmartTots | Jan 14, 2020 | Research Articles
Abstract Editor’s Perspective: What We Already Know about This Topic: Oligodendrocyte proliferation and maturation are prerequisites for myelination in the central nervous system. Disruption of these processes can lead to long-term impairment of neural function....
