by SmartTots | Feb 14, 2026 | Clinical Articles, Research Articles
As early as 1999, research began showing that general anesthetic drugs, once assumed to have no lasting effects after elimination from the body, may potentially impact brain development, prompting concerns about their safety in infants and young children. In response,...
by SmartTots | Feb 14, 2026 | Clinical Articles, Research Articles
Abstract Background: Anesthetic exposure in young children raises concerns about neurodevelopmental safety, with preclinical evidence suggesting potential neurotoxicity of volatile anesthetics. This study aimed to assess whether the combination of dexmedetomidine and...
by SmartTots | Feb 14, 2026 | Clinical Articles, Research Articles
Abstract Although anesthesia makes painful or uncomfortable diagnostic and interventional health care procedures tolerable, it may also disrupt key cellular processes in neurons and glia, harm the developing brain, and thereby impair cognition and behavior in...
by SmartTots | Feb 14, 2026 | Clinical Articles, Research Articles
Abstract Anesthetics and sedatives may cause long-term negative neurocognitive consequences in children. Many clinical reports on this subject have had a profound impact on the field of clinical pediatric anesthesiology. Findings from animal models suggest that early...
by SmartTots | Feb 14, 2026 | Clinical Articles, Research Articles
Abstract Background: The impact of anesthesia and surgery on neurocognitive and behavioral development in infants and children remains inadequately understood. Objective: To investigate the impact of early-life exposure to general anesthesia and surgery on cognitive...
by SmartTots | Feb 14, 2026 | Preclinical Articles, Research Articles
Abstract Background: Normal sleep architecture is important for brain development, and we previously demonstrated that a single exposure to isoflurane during the neonatal period did not induce changes in the sleep architecture and only minimally altered neuronal beta...
