by SmartTots | May 1, 2021 | Research Articles
Abstract Background Both animal and retrospective human studies have linked extended and repeated general anaesthesia during early development with cognitive and behavioural deficits later in life. However, the neuronal circuit mechanisms underlying this...
by SmartTots | May 1, 2021 | Research Articles
Abstract Ketamine is a widely used analgesic and anesthetic in obstetrics and pediatrics. Ketamine is known to promote neuronal death and cognitive dysfunction in the brains of humans and animals during development. Monosialotetrahexosyl ganglioside (GM1), a promoter...
by SmartTots | May 1, 2021 | Research Articles
Abstract The potential adverse impact of inhalational anesthetics on the developing brain was highlighted by the addition of a medication warning by the U.S. Food and Drug Administration for their use in the pediatric population. To investigate mechanisms by which...
by SmartTots | May 1, 2021 | Research Articles
Abstract Background To investigate the neuroprotective effect of edaravone on excessive-dose propofol-induced neurotoxicity in the hippocampus of newborn rats and HT22 cells. Methods Cell proliferation was investigated by assessing ki67 expression in the neural stem...
by SmartTots | May 1, 2021 | Research Articles
Abstract Background Structural brain abnormalities in newborn animals after prolonged exposure to all routinely used general anaesthetics have raised substantial concerns for similar effects occurring in millions of children undergoing surgeries annually. Combining a...
by SmartTots | May 1, 2021 | Research Articles
Abstract Anesthetic-induced toxicity in early life may lead to risk of cognitive decline at later ages. Notably, multiple exposures to isoflurane (ISO) cause acute apoptotic cell death in the developing brain and long-term cognitive dysfunction. This study is the...
