by SmartTots | Nov 3, 2019 | Research Articles
Abstract Aims: It is well established that exposure of common anesthetic isoflurane in early life can induce neuronal apoptosis and long-lasting cognitive deficit, but the underlying mechanisms were not well understood. The cell cycle protein Cyclin B1 plays an...
by SmartTots | Nov 3, 2019 | Research Articles
Abstract Early life exposure to general anesthetics can have neurotoxic consequences. Evidence indicates that xenon, a rare noble gas with anesthetic properties, may lessen neuronal damage under certain conditions. However, its potential neuroprotective properties,...
by SmartTots | Nov 3, 2019 | Research Articles
Abstract Rationale: Animal studies have shown that early postnatal propofol administration is involved in neurobehavioral alterations in adults. However, the underlying mechanism is not clear. Methods: We used c-Fos immunohistochemistry to identify activated neurons...
by SmartTots | Nov 3, 2019 | Research Articles
Abstract Purpose: Evidence has shown that propofol may cause widespread apoptotic neurodegeneration. Hypoxic preconditioning has been demonstrated to provide neuroprotection and brain recovery from both acute and chronic neurodegeneration in several cellular and...
by SmartTots | Nov 3, 2019 | Research Articles
Abstract Excessive exposure to commonly used anesthetic agents, such as ketamine, may induce permanent damage to immature human brains. In this work, we used a human embryonic stem cell (hESC)-derived neuron model to assess the expression and function of human...
by SmartTots | Nov 3, 2019 | Research Articles
Abstract Most clinically used general anesthetics have demonstrated neurotoxicity in animal studies, but the related mechanisms remain unknown. Previous studies suggest that anesthetics affect neuronal development through neuroinflammation, and significant effects of...
