by SmartTots | Nov 1, 2018 | Research Articles
The primary objective of this study was to describe in a geographically defined population the incidence of procedures requiring general anesthesia up to the child’s third birthday, and the patient characteristics associated with receiving these procedures. A...
by SmartTots | Nov 1, 2018 | Research Articles
Abstract BACKGROUND: The majority of studies evaluating neurocognition in humans who had procedures under anesthesia early in life found long-term deficits even though the typical anesthesia duration normalized to the human life span is much shorter than that shown to...
by SmartTots | Nov 1, 2018 | Research Articles
Abstract BACKGROUND: Growing animal evidence demonstrates that prolonged exposure to propofol during brain development induces widespread neuronal cell death, but there is little information on the role of astrocytes. Astrocytes can release neurotrophic growth factors...
by SmartTots | Nov 1, 2018 | Research Articles
Abstract Human epidemiologic studies and laboratory investigations in animal models suggest that exposure to general anesthetic agents (GAs) have harmful effects on brain development. The mechanism underlying this putative iatrogenic condition is not clear and there...
by SmartTots | Nov 1, 2018 | Research Articles
Abstract N-acetylcysteine, a precursor molecule of glutathione, is an antioxidant. Ketamine, a pediatric anesthetic, has been implicated in cardiotoxicity and neurotoxicity including modulation of monoaminergic systems in mammals and zebrafish. Here, we show that...
by SmartTots | Nov 1, 2018 | Research Articles
Abstract BACKGROUND: Clinical studies report learning disabilities and attention-deficit/hyperactivity disorders in those exposed to general anaesthesia early in life. Rats, primarily males, exposed to GABAergic anaesthetics as neonates exhibit behavioural...
