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Comparer Pommes et Oranges: Perils of Translating Rodent Studies to Human Outcomes

by SmartTots | Jan 16, 2023 | Clinical Articles, Research Articles

This editorial critiques the study by Salaün et al as it attempts to translate findings on the effects of anesthesia in neonatal rodents to children. There are many problems with this comparison: 1) investigators have no access to past anesthesia records in human...

Repeated sevoflurane exposures inhibit neurogenesis by inducing the upregulation of glutamate transporter 1 in astrocytes.

by SmartTots | Jan 4, 2023 | Preclinical Articles, Research Articles

Abstract Sevoflurane is a widely used general anaesthetic in paediatric patients. Although repeated sevoflurane exposure is known to cause neurodevelopmental disorders in children, the mechanism of this neurotoxicity remains largely unknown. Herein, we investigated...

The propofol-induced mitochondrial damage in fetal rat hippocampal neurons via the AMPK/P53 signaling pathway.

by SmartTots | Jan 4, 2023 | Preclinical Articles, Research Articles

Abstract Background Propofol is a commonly used general anesthetic that may cause neuronal damage, especially in infants and young children. Mitochondria play an essential role in cellular metabolism and signal transduction. Propofol may cause neurotoxicity by...

Ketamine modulates neural stem cell differentiation by regulating TRPC3 expression through the GSK3β/β-catenin pathway.

by SmartTots | Jan 4, 2023 | Preclinical Articles, Research Articles

Abstract Ketamine, a popular anesthetic, is often abused by people for its hallucinogenic effect. Thus, the safety of ketamine in pediatric populations has been called into question for potential neurotoxic effects. However, ketamine also has neuroprotective effects...

Sevoflurane induces microRNA-18a to delay rat neurodevelopment via suppression of the RUNX1/Wnt/β-catenin axis.

by SmartTots | Jan 4, 2023 | Preclinical Articles, Research Articles

Abstract Sevoflurane anesthesia is reported to repress neurogenesis of neural stem cells (NSCs), thereby affecting the brain development, but the underlying mechanism of sevoflurane on the proliferation of NSCs remains unclear. Thus, this study aims to discern the...

Neonatal exposures to sevoflurane in rhesus monkeys alter synaptic ultrastructure in later life.

by SmartTots | Jan 4, 2023 | Preclinical Articles, Research Articles

Abstract Repeated or prolonged early life exposure to anesthesia is neurotoxic in animals and associated with neurocognitive impairment in later life in humans. We used electron microscopy with unbiased stereological sampling to assess synaptic ultrastructure in...
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Recent Posts

  • Comparer Pommes et Oranges: Perils of Translating Rodent Studies to Human Outcomes
  • Repeated sevoflurane exposures inhibit neurogenesis by inducing the upregulation of glutamate transporter 1 in astrocytes.
  • The propofol-induced mitochondrial damage in fetal rat hippocampal neurons via the AMPK/P53 signaling pathway.
  • Ketamine modulates neural stem cell differentiation by regulating TRPC3 expression through the GSK3β/β-catenin pathway.
  • Sevoflurane induces microRNA-18a to delay rat neurodevelopment via suppression of the RUNX1/Wnt/β-catenin axis.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

90 New Montgomery Street
Suite 412
San Francisco, CA 94105
Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

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SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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