Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN): a multicentre, open-label, randomised controlled phase 4 trial. Claire Elizabeth Wainwright, et al. June 2024

by | Jun 17, 2024 | Clinical Articles, News, Research Articles

Data gathered from the original Australasian Cystic Fibrosis Bronchoalveolar Lavage (ACFBAL) trial provided a unique, optimal opportunity to examine the long-term effects of multiple exposures to general anaesthesia in a randomised controlled trial setting.  The...

Columbia University Physician Scientist and SmartTots Investigator, Caleb Ing, MD, publishes new findings regarding prenatal exposure to general anesthesia and subsequent risk to the child.

by | May 24, 2024 | Clinical Articles, News, Research Articles

The association between prenatal exposure to general anaesthesia for maternal surgery during pregnancy and subsequent risk of disruptive or internalising behavioural disorder diagnosis in the child has not been well-defined. Columbia researchers, led by Caleb Ing,...

TREX Trial Milestone – Enrollment is complete!

by | Apr 28, 2023 | News

The TREX (Toxicity Remifentanil DEXmedetomidine) Trial Investigators are pleased to announce the completion of enrollment of the 450 trial subjects. The TREX Trial is a multicenter, multinational study of two anesthetic regimens for prolonged anesthesia in infants and...

SmartTots: 13 Years of Progress

by | Oct 12, 2022 | News

During the 2000’s, preclinical research studies began to find that laboratory animals exposed to commonly used anesthetic and sedative drugs early in life showed changes to the brain and nervous system that interfered with memory and learning.  Additional research...