SmartTots
  • Home
  • About
    • Who We Are
    • FAQ
  • News
  • Resources
    • Healthcare Professionals Resources
    • Advice for Parents and Caregivers
    • Clinical Research Articles
    • Preclinical Research Articles
    • Live Stream
    • Newsletter Archive
    • Presentation Videos
    • Research and Grants
    • FDA Drug Safety Communication
  • Donor Recognition
  • Newsletter Signup
  • Contact
Select Page

Unanswered questions of anesthesia neurotoxicity in the developing brain.

by SmartTots | Aug 31, 2023 | Clinical Articles, Research Articles

Abstract Purpose of review: This article reviews recent advances and controversies of developmental anesthesia neurotoxicity research with a special focus on the unanswered questions in the field both from clinical and preclinical perspectives. Recent...

Anesthesia, the developing brain, and dexmedetomidine for neuroprotection.

by SmartTots | Aug 31, 2023 | Clinical Articles, Research Articles

Anesthesia-induced neurotoxicity is a set of unfavorable adverse effects on central or peripheral nervous systems associated with administration of anesthesia. Several animal model studies from the early 2000’s, from rodents to non-human primates, have shown that...

Association between maternal labour epidural analgesia and autistic traits in offspring.

by SmartTots | Aug 31, 2023 | Clinical Articles, Research Articles

Abstract Study objective: Studies investigating associations between maternal epidural analgesia (MEA) and autism spectrum disorder (ASD) in the offspring are conflicting and lack prospective neurobehavioral follow-up assessments for autistic traits. We aim to...

First anesthesia exposure effects on short-term neurocognitive function among 1- to 36-month-old children: a case-control pilot study.

by SmartTots | Aug 31, 2023 | Clinical Articles, Research Articles

Abstract Background: Multiple human studies have shown no significant long-term results of anesthesia exposure during early childhood compared to the general population; however, reports on short-term neurodevelopmental assessment before and after anesthesia exposure...

Clinical investigations on anesthesia-induced developmental neurotoxicity: The knowns, the unknowns and future prospects.

by SmartTots | Jun 28, 2023 | Clinical Articles, Research Articles

Abstract Pre-clinical experimental evidence, along with a plausible biological rational suggests that exposure of neonates and young children to anesthesia may harm brain development. However, the translational relevance of these observations remains unsolved. While a...

Neuroprotective strategies in anesthesia-induced neurotoxicity.

by SmartTots | Jun 28, 2023 | Clinical Articles, Research Articles

Abstract Over the past 20 years, hundreds of preclinical studies of the developing central nervous system have been published concluding that the common γ-aminobutryic acid and N-methyl-d-aspartate binding anesthetic agents cause neuroapoptosis and other forms of...
« Older Entries

Categories

  • Clinical Articles
  • Events
  • News
  • Preclinical Articles
  • Research Articles

Recent Posts

  • Editorial: Anesthetic neurotoxicity in developing brains: mechanisms, biomarkers, and therapeutic targets.
  • Development of a primate model to evaluate the effects of ketamine and surgical stress on the neonatal brain.
  • Sevoflurane anaesthesia induces cognitive impairment in young mice through sequential tau phosphorylation.
  • Dexmedetomidine suppresses hippocampal astrocyte pyroptosis in cerebral hypoxic-ischemic neonatal rats by upregulating microRNA-148a-3p to inactivate the STAT/JMJD3 axis.
  • miR-34a targets SIRT1 to reduce p53 deacetylation and promote sevoflurane inhalation anesthesia-induced neuronal autophagy and apoptosis in neonatal mice.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

Tax Information

SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

GuideStar/Candid

Guidestar

View our Summary

  • Privacy Policy
  • Terms of Use
  • International Anesthesia Research Society
  • Newsletter Signup
  • X

Designed by Elegant Themes | Powered by WordPress