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Comparer Pommes et Oranges: Perils of Translating Rodent Studies to Human Outcomes

by SmartTots | Jan 16, 2023 | Clinical Articles, Research Articles

This editorial critiques the study by Salaün et al as it attempts to translate findings on the effects of anesthesia in neonatal rodents to children. There are many problems with this comparison: 1) investigators have no access to past anesthesia records in human...

Neurotoxic Impact of Individual Anesthetic Agents on the Developing Brain.

by SmartTots | Jan 4, 2023 | Clinical Articles, Research Articles

Abstract Concerns about the safety of anesthetic agents in children arose after animal studies revealed disruptions in neurodevelopment after exposure to commonly used anesthetic drugs. These animal studies revealed that volatile inhalational agents, propofol,...

Anesthesia and developing brain: What have we learned from recent studies.

by SmartTots | Jan 4, 2023 | Clinical Articles, Research Articles

Abstract Anesthesia is unavoidable in surgical procedures. However, whether the general anesthetics are neurotoxic to immature brains remains undefined. Neurodevelopmental impairment induced by anesthesia has been a critical health issue and topic of concern. This...

Anesthesia and neurodevelopment after 20 years: where are we now and where to next?

by SmartTots | Jan 4, 2023 | Clinical Articles, Research Articles

This editorial discusses recent government warnings on anesthesia in pregnant women and young children, the latest findings from clinical trials, unanswered questions about anesthesia and its association to neurotoxicity, and new directions in pediatric anesthesia...

Environmental enrichment holds promise as a novel treatment for anesthesia-induced neurocognitive disorders.

by SmartTots | Jan 4, 2023 | Clinical Articles, Research Articles

Abstract In recent years, since the need for anesthetic interventions in pregnant women, newborns, and older patients has been increasing, the anesthesia-induced cognitive impairment has received widespread attention and highlighted the urgent requirement for...

Readability, Content, and Quality of Online Patient Education Materials on Anesthesia and Neurotoxicity in the Pediatric Population.

by SmartTots | Jan 4, 2023 | Clinical Articles, Research Articles

Abstract Objective: Internet-based patient education materials (PEMs) are often above the recommended sixth grade reading level recommended by the U.S. Department of Health and Human Services. In 2016 the U.S. Food and Drug Administration (FDA) released a warning...
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Recent Posts

  • Comparer Pommes et Oranges: Perils of Translating Rodent Studies to Human Outcomes
  • Repeated sevoflurane exposures inhibit neurogenesis by inducing the upregulation of glutamate transporter 1 in astrocytes.
  • The propofol-induced mitochondrial damage in fetal rat hippocampal neurons via the AMPK/P53 signaling pathway.
  • Ketamine modulates neural stem cell differentiation by regulating TRPC3 expression through the GSK3β/β-catenin pathway.
  • Sevoflurane induces microRNA-18a to delay rat neurodevelopment via suppression of the RUNX1/Wnt/β-catenin axis.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

90 New Montgomery Street
Suite 412
San Francisco, CA 94105
Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

Tax Information

SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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