Resources

Postoperative Delirium, Learning, and Anesthetic Neurotoxicity: Some Perspectives and Directions.
Frontiers in Neurology. March 2018

Reducing the Number of Anesthetic Exposures in the Early Years of Life: Circumcision and Myringotomy as an Example.
Clinical Pediatrics. March 2018

A Systematic Review of Risk Factors Associated With Cognitive Impairment After Pediatric Critical Illness.
Pediatric Critical Care Medicine. March 2018

S100β in newborns after C-section with general vs. epidural anesthesia: a prospective observational study.
Acta Anaesthesiologica Scandinavica. March 2018

Changes in sensory processing after anesthesia in toddlers.
Minerva Anestesiologica. February 5, 2018

Lipoic acid inhibited desflurane-induced hippocampal neuronal apoptosis through Caspase3 and NF-KappaB dependent pathway.
Tissue & Cell.” February 2018

Changes in tissue and cerebral oxygenation following spinal anesthesia in infants: a prospective study.
Journal of Anesthesia. January 12, 2018

Reducing sedation for pediatric body MRI using accelerated and abbreviated imaging protocols.
Pediatric Radiology. January 2018

Food and Drug Administration warning on anesthesia and brain development: implications for obstetric and fetal surgery.
American Journal of Obstetrics and Gynecology. January 2018

Pediatric Anesthesia Considerations for Interventional Radiology
Anesthesiology December 2017

Challenges in the anesthetic management of ambulatory patients in the MRI suites
Current Opinion in Anestiology December 2017

Xenon as an adjuvant to sevoflurane anesthesia in children younger than 4 years of age, undergoing interventional or diagnostic cardiac catheterization: A randomized controlled clinical trial 
Paediatric anaesthesia December 2017

Caffeine combined with sedative/anesthetic drugs triggers widespread neuroapoptosis in a mouse model of prematurity
The Journal of Maternal-Fetal & Neonatal Medicine December 2017

Hydrogen gas attenuates sevoflurane neurotoxicity through inhibiting nuclear factor κ-light-chain-enhancer of activated B cells signaling and proinflammatory cytokine release in neonatal rats
NeuroRepprt December 6, 2017

Protective effects of a green tea polyphenol, epigallocatechin-3-gallate, against sevoflurane-induced neuronal apoptosis involve regulation of CREB/BDNF/TrkB and PI3K/Akt/mTOR signaling pathways in neonatal mice
Canadian Journal of Physiology and Pharmacology 2017 Dec

Exposure of Developing Brain to General Anesthesia: What Is the Animal Evidence?
Anesthesiology. 2017 Dec 22

Systematic review of the neurocognitive outcomes used in studies of paediatric anaesthesia neurotoxicity.
British Journal of Anaesthesia. November 21, 2017

Effect of repeated neonatal sevoflurane exposure on the learning, memory and synaptic plasticity at juvenile and adult age.
American Journal of Translational Research. November 15, 2017

Repeated 2% sevoflurane administration in 7‑ and 60-day-old rats : Neurotoxicity and neurocognitive dysfunction.
Der Anaesthesist. November 2017

Caffeine combined with sedative/anesthetic drugs triggers widespread neuroapoptosis in a mouse model of prematurity
The Journal of Maternal-Fetal & Neonatal Medicine November 2017

Predictors of Anesthetic Duration in Common Pediatric General Surgical Procedures
Anesthesioligy Today

Isoflurane exposure regulates the cell viability and BDNF expression of astrocytes via upregulation of TREK‑1
Mol Med Rep. 2017 Nov

Subsequent maternal separation exacerbates neurobehavioral abnormalities in rats neonatally exposed to sevoflurane anesthesia
Neuroscience Letters 20 November 2017

Epidemiology of Exposure to Anesthesia, Surgery, and Mortality in a Children’s Hospital Population
American Society of Anesthesiologists. October 21, 2017

Perinatal and neonatal use of sedation and analgesia
sfnm journal. October 7, 17

Non-Anaesthetic Effects of Volatile Anaesthetics: A Short Trip on the Sea of Translational Medicine October 2017

Debate Over Neurotoxicity in Pediatric Anesthesia Draws No Firm Conclusions
Clinical Anesthesiology September 5, 2017

Alternative technique or mitigating strategy for sevoflurane-induced neurodegeneration: a randomized controlled dose-escalation study of dexmedetomidine in neonatal rats
BJA: British Journal of Anaesthesia, 1 September 2017

Reproducibility of science and developmental anaesthesia neurotoxicity: a tale of two cities.
British Journal of Anaesthesia. September 2017

Editorial: Can We Really Suggest that Anesthesia Might Cause Attention-deficit/Hyperactivity Disorder?
Anesthesiology, August 2017

Association between Exposure of Young Children to Procedures Requiring General Anesthesia and Learning and Behavioral Outcomes in a Population-based Birth Cohort
Anesthesiology, August 2017

Overexpression cdc42 attenuates isoflurane-induced neurotoxicity in developmental brain of rats
Biochemical and Biophysical Research Communications 26 August 2017

Neonatal Propofol Anesthesia Changes Expression of Synaptic Plasticity Proteins and Increases Stereotypic and Anxyolitic Behavior in Adult Rats
Neurotox Res. 2017 Aug

Dexmedetomidine Mitigates Neuroapoptosis Induced by Prenatal Intravenous Anesthetic Exposure in Rats
Presented at ASA, October 26, 2015.

Latent Class Analysis of Neuropsychological Deficit After Exposure to Anesthesia in Early Childhood
Presented at ASA, October 26, 2015.

Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial
The Lancet, October 24, 2015.

Anaesthetics, infants, and neurodevelopment: case closed?
The Lancet, October 24, 2015.

Neonatal MRI: Can We Reduce Anesthesia Exposure? A National Survey
Presented at ASA, October 24, 2015.

Estimation and Analysis of Unnecessarily Early Procedures in Infants Younger than Six Month of Age in the United States
Presented at ASA, October 24, 2015.

Development of a Translational, Preclinical Piglet Model of Anesthesia-Induced Neurotoxicity Mechanisms in the Pediatric Population
Presented at ASA, October 24, 2015.

Identifying Children at Risk for Anesthetic Neurotoxicity
The Lancet, October 24, 2015.

Negotiating the dilemma of anaesthesia and sedation in NICUs
Presented at ASA, October 7, 2015.

Can we reduce anesthesia exposure? Neonatal brain MRI: Swaddling vs. sedation, a national survey
JOURNAL OF CLINICAL ANESTHESIA May 2017

Optimization of Pediatric PET/CT
Semin Nucl Med. 2017 May

Visual recognition memory is impaired in rhesus monkeys repeatedly exposed to sevoflurane in infancy
Br J Anaesth aew473 31 May 2017

Elamipretide (SS-31) Ameliorates Isoflurane-Induced Long-Term Impairments of Mitochondrial Morphogenesis and Cognition in Developing Rats
Front Cell Neurosci 2017 Apr 25

Neurotoxicity of Generic Anesthesia Agents in Infants and Children: An Orphan Research Question in Search of a Sponsor
JAMA, April 12, 2015.

Only extra-high dose of ketamine affects l-glutamate-induced intracellular Ca2+ elevation and neurotoxicity
Neurosci Res, April 10, 2015.

Is There Evidence for Long-Term Neurocognitive Effects of Sedatives
Pediatric Sedation Outside of the Operating Room: A Multispecialty International Collaboration, April 6,2015.

Repeated Exposure to Ketamine-Xylazine during Early Development Impairs Motor Learning-dependent Dendritic Spine Plasticity in Adulthood
Anesthesiology, April 4, 2015.

Dexmedetomidine Attenuates Neurotoxicity Induced by Prenatal Propofol Exposure.
J Neurosurg Anesthesiol, April 4, 2015.

Neurodevelopmental implications of the general anesthesia in neonate and infants
Exp Neurol, April 3, 2015.

Isoflurane induced cognitive impairment in aged rats through hippocampal calcineurin/NFAT signaling
Biochem Biophys Res Commun, April 3, 2015.

Oregon Health & Science University: Ansgar Brambrink, MD, PhD
SmartTots, April 2, 2015.

Developmental stage-dependent impact of midazolam on calbindin, calretinin and parvalbumin expression in the immature rat medial prefrontal cortex during the brain growth spurt.
Int J Dev Neurosci, April 2, 2015.

A comparison of functional magnetic resonance imaging findings in children with and without a history of early exposure to general anesthesia
Paediatr Anaesth, March 2015.

Pre-treatment with a Xingnaojing preparation ameliorates sevoflurane-induced neuroapoptosis in the infant rat striatum.
Mol Med Rep, March 2015.

Effect of apoptosis in neural stem cells treated with sevoflurane
BioMed Central Anesthesiology, 2015.

Neuroprotective effects of pterostilbene against isoflurane-induced apoptosis through regulating the JNK and PI3K/Akt pathway in neonatal rats
Bangladesh Journal of Pharmacology, 2015.

Repeated Exposure to Ketamine-Xylazine during Early Development Impairs Motor Learning-dependent Dendritic Spine Plasticity in Adulthood
Anesthesiology, 2015.

Additives to local anesthetics for peripheral nerve blocks or local anesthesia: a review of the literature
Pain Manag, March 2015.

Interventional Procedures for Chronic Pain in Children and Adolescents: A Review of the Current Evidence
Pain Pract,, March 2015.

Safety and feasibility of xenon as an adjuvant to sevoflurane anaesthesia in children undergoing interventional or diagnostic cardiac catheterization: study protocol for a randomised controlled trial
Trials, March 2015.

Anesthetic neurotoxicity–clinical implications of animal models
N Engl J Med, February 2015.

Dexamethasone but not the equivalent doses of hydrocortisone induces neurotoxicity in neonatal rat brain.
Pediatr Res, February 2015.

Is There Evidence for Long-Term Neurocognitive Effects of Sedatives
Pediatric Sedation Outside of the Operating Room: A Multispecialty International Collaboration, 2015.