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NPAS4 suppresses propofol-induced neurotoxicity by inhibiting autophagy in hippocampal neuronal cells.
Archives of Biochemistry and Biophysics October 30, 2021
Astrogliosis in juvenile non-human primates 2 years after infant anaesthesia exposure.
British Journal of Anaesthesia September 2021
Does Anesthesia and Surgery During Pregnancy Really Affect Learning and Behavior in the Offspring: The Holy Grail in Anesthesiology Research.
Anesthesia & Analgesia September 2021
Repeated neonatal sevoflurane induced neurocognitive impairment through NF-κB-mediated pyroptosis.
Journal of Neuroinflammation August 21, 2021
Dexmedetomidine does not compromise neuronal viability, synaptic connectivity, learning and memory in a rodent model.
Scientific Reports August 9, 2021
The Increased Channel Activity of N-Methyl-D-Aspartate Receptors at Extrasynaptic Sites in the Anterior Cingulate Cortex of Neonatal Rats Following Prolonged Ketamine Exposure.
Journal of Pain Research August 8, 2021
Neuroprotective Effects of Dexmedetomidine on the Ketamine-Induced Disruption of the Proliferation and Differentiation of Developing Neural Stem Cells in the Subventricular Zone.
Frontiers in Pediatrics July 27, 2021
Effects of sevoflurane exposure during different stages of pregnancy on the brain development of rat offspring.
Journal of Anesthesia July 19, 2021
Long-term evidence of neonatal anaesthesia neurotoxicity linked to behavioural phenotypes in monkeys: where do we go from here?
British Journal of Anesthaesia July 13, 2021
Neonatal Anesthesia and dysregulation of the Epigenome. Cabrera, Useinovic, Jevtovic-Todorovic.
Biology of Reproduction July 13, 2021
Association Between Behavioral and Learning Outcomes and Single Exposures to Procedures Requiring General Anesthesia Before Age 3: Secondary Analysis of Data From Olmsted County, MN.
Anesthesia & Analgesia July 2021
Research Progress of Pharmacological Intervention of Sevoflurane-induced Nerve Injury in the Developing Brain.
ACTA ACADEMIAE MEDICINAE SINICAE June 30, 2021
Neonatal administration of a subanaesthetic dose of JM-1232(-) in mice results in no behavioural deficits in adulthood.
Scientific Reports June 18, 2021
Testosterone is Sufficient to Impart Susceptibility to Isoflurane Neurotoxicity in Female Neonatal Rats.
Journal of Neurosurgical Anesthesiology June 15, 2021
Histone Deacetylase 2-Mediated Epigenetic Regulation is Involved in the Early Isoflurane Exposure-Related Increase in Susceptibility to Anxiety-Like Behaviour Evoked by Chronic Variable Stress in Mice.
Neurochemical Research June 8, 2021
lncRNA Xist regulates sevoflurane-induced social and emotional impairment by modulating miR-98-5p/EDEM1 signaling axis in neonatal mice.
Molecular Therapy – Nucleic Acids June 4, 2021
Parental Decision-Making for Surgery and Anesthesia in Young Children.
Western Journal of Nursing Research June 4, 2021
A decade later, there are still major issues to be addressed in paediatric anaesthesia.
Current Opinion in Anaesthesiology June 2021
Effect of operative trauma and multiple propofol anesthesia on neurodevelopment and cognitive function in developmental rats.
Journal of Zhejiang University (Medical Sciences) June 2021
Maternal sevoflurane exposure induces temporary defects in interkinetic nuclear migration of radial glial progenitors in the fetal cerebral cortex through the Notch signalling pathway.
Cell Proliferation June 2021
Evaluation of the Neuroprotective Effect of Pycnogenol in a Hypoxic-Ischemic Brain Injury Model in Newborn Rats.
American Journal of Perinatology May 27, 2021
Recent advances in understanding cognitive and behavioural alterations after early-in-life anaesthesia exposure and new mitigation/alternative strategies in preclinical studies.
Current Opinion in Anaesthesiology May 18, 2021
Why do We Use the Concepts of Adult Anesthesia Pharmacology in Developing Brains? Will It Have an Impact on Outcomes? Challenges in Neuromonitoring and Pharmacology in Pediatric Anesthesia.
J Clin Med May 18, 2021
RIPK1/RIPK3-Mediated Necroptosis is Involved in Sevoflurane-Induced Neonatal Neurotoxicity in the Rat Hippocampus.
Cellular and Molecular Neurobiology May 15, 2021
Maternal anesthesia with sevoflurane during the mid-gestation induces social interaction deficits in offspring C57BL/6 mice.
Biochemical and Biophysical Research Communications May 14, 2021
The effect of xenon on fetal neurodevelopment following maternal sevoflurane anesthesia and laparotomy in rabbits.
Neurotoxicology and Teratology May 5, 2021
Accounting for General Anesthesia: A Pre-Op Primer and Post-Op Factor.
Pediatric Annals May 1, 2021
Effect of dexmedetomidine on sevoflurane-induced neurodegeneration in neonatal rats.
British Journal of Anaesthesia May 2021
Effects of sevoflurane general anesthesia during early pregnancy on AIM2 expression in the hippocampus and parietal cortex of Sprague-Dawley offspring rats.
Experimental and Therapeutic Medicine May 2021
Longitudinal associations between exposure to anesthesia and neurocognitive functioning in pediatric medulloblastoma.
European Journal of Cancer May 2021
Sevoflurane impairs m6A-mediated mRNA translation and leads to fine motor and cognitive deficits.
Cell Biology and Toxicology April 29, 2021
Ferroptosis contributes to isoflurane-induced neurotoxicity and learning and memory impairment.
Cell Death Discovery April 7, 2021
Long Noncoding RNA SPRY4-IT1 Modulates Ketamine-Induced Neurotoxicity in Human Embryonic Stem Cell-Derived Neurons through EZH2.
Developmental Neuroscience April 7, 2021
Effects of general anaesthesia during pregnancy on neurocognitive development of the fetus: a systematic review and meta-analysis.
British Journal of Anaesthesia April 6, 2021
Intrapartum opioid analgesia and childhood neurodevelopmental outcomes among infants born preterm.
American Journal of Obstetrics & Gynecology MFM April 5, 2021
Anaesthesia, neural activity, and brain development: interneurones in the spotlight.
British Journal of Anaesthesia April 1, 2021
Ketamine inhibits neuronal differentiation by regulating brain-derived neurotrophic factor (BDNF) signaling
Toxicology in Vitro April 2021
MicroRNA-1297 suppressed the Akt/GSK3 β signaling pathway and stimulated neural apoptosis in an in vivo sevoflurane exposure model
Journal of International Medical Research April 2021
Anesthetic Exposure in Staged Versus Single-Stage Cleft Lip and Palate Repair: Can We Reduce Risk of Anesthesia-Induced Developmental Neurotoxicity?
Journal of Craniofacial Surgery March-April 2021
Edaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway.
Drug Design, Development and Therapy March 30, 2021
Intranasal levosimendan prevents cognitive dysfunction and apoptotic response induced by repeated isoflurane exposure in newborn rats.
Naunyn-Schmiedeberg’s Archives of Pharmacology March 27, 2021
Protective Effect of GM1 Attenuates Hippocampus and Cortex Apoptosis After Ketamine Exposure in Neonatal Rat via PI3K/AKT/GSK3β Pathway.
Molecular Neurobiology March 17, 2021
Prediction of levobupivacaine concentrations in neonates and infants following neuraxial rescue blocks.
Pediatric Anesthesia March 8, 2021
Anesthesia and the Developing Brain: A Review of Sevoflurane-induced Neurotoxicity in Pediatric Populations.
Clinical Therapeutics March 2, 2021
Predictors of Anesthetic Exposure in Pediatric MRI.
American Journal of Roentgenology March 2021
Ketamine-induced neurotoxicity in neurodevelopment: A synopsis of main pathways based on recent in vivo experimental findings.
Journal of Anaesthesiology Clinical Pharmacology January-March 2021
Behavioural impairments after exposure of neonatal mice to propofol are accompanied by reductions in neuronal activity in cortical circuitry.
British Journal of Anaesthesia February 26, 2021
A synthetic peptide rescues rat cortical neurons from anesthetic-induced cell death, perturbation of growth and synaptic assembly
Scientific Reports February 25, 2021
FOXO3 Regulates Sevoflurane-Induced Neural Stem Cell Differentiation in Fetal Rats
Cellular and Molecular Neurobiology February 19, 2021
Developmental exposure to general anaesthesia: missed connections?
British Journal of Anaesthesia February 11, 2021
Changes in Plasma Glial Fibrillary Acidic Protein in Children Receiving Sevoflurane Anesthesia: A Preliminary Randomized Trial.
Journal of Clinical Medicine February 9, 2021
General anaesthesia during infancy reduces white matter micro-organisation in developing rhesus monkeys
British Journal of Anaesthesia February 3, 2021
Epidural analgesia, intrapartum hyperthermia, and neonatal brain injury: a systematic review and meta-analysis.
British Journal of Anaesthesia February 2021
Expression Signature of lncRNAs and mRNAs in Sevoflurane-Induced Mouse Brain Injury: Implication of Involvement of Wide Molecular Networks and Pathways
International Journal of Molecular Sciences January 30, 2021
Detrimental effects of general anaesthesia on young primates: are we closer to understanding the link?
British Journal of Anaesthesia January 25, 2021
Prenatal Exposure to General Anesthesia and Childhood Behavioral Deficit
Pediatric Anesthesia January 22, 2021
The effects of early anesthesia on neurodevelopment: A systematic review
The Journal of Pediatrics January 19, 2021
The Role of the lncRNA-LRCF in Propofol-Induced Oligodendrocyte Damage in Neonatal Mouse
Neurochemical Research January 7, 2021
Dexmedetomidine attenuates sevoflurane‑induced neurocognitive impairment through α2‑adrenoceptors
Molecular Medicine Reports January 2021
Fundamentals and innovations in regional anaesthesia for infants and children.
Anaesthesia January 2021
Resveratrol ameliorates sevoflurane-induced cognitive impairment by activating the SIRT1/NF-κB pathway in neonatal mice
Journal of Nutritional Biochemistry December 31, 2020
Hypermethylation of EFEMP1 in the Hippocampus May Be Related to the Deficit in Spatial Memory of Rat Neonates Triggered by Repeated Administration of Propofol.
BioMed Research International December 19, 2020
Emerging Role of Long Noncoding RNAs in Perioperative Neurocognitive Disorders and Anesthetic-Induced Developmental Neurotoxicity
Anesthesia & Analgesia December 16, 2020
Hypotension and adverse neurodevelopmental outcomes among children with multiple exposures to general anesthesia: Subanalysis of the Mayo Anesthesia Safety in Kids (MASK) Study
Paediatric Anaesthesia December 15, 2020
Sevoflurane-induced neuronal apoptosis in neonatal mice is prevented with intranasal administration of insulin
American Journal of Translational Research December 15, 2020
Neurodevelopmental Outcomes after Premedication with Atropine/Propofol vs Atropine/Atracurium/Sufentanil for Neonatal Intubation: 2-Year Follow-Up of a Randomized Clinical Trial
The Journal of Pediatrics December 8, 2020
Sevoflurane Exposure Induces Neuronal Cell Parthanatos Initiated by DNA Damage in the Developing Brain via an Increase of Intracellular Reactive Oxygen Species
Frontiers in Cellular Neuroscience December 3, 2020
Neonatal exposure to ketamine disrupts developmental synapse unsilencing and predisposes adult mice for stressor-evoked anxiety
Neuropharmacology December 1, 2020
Prenatal sevoflurane exposure: Effects of iron metabolic dysfunction on offspring cognition and potential mechanism
International Journal of Developmental Neuroscience December 1, 2020
Prospectively assessed neurodevelopmental outcomes in studies of anaesthetic neurotoxicity in children: a systematic review and meta-analysis
British Journal of Anaesthesia November 27, 2020
Interval-dependent neurotoxicity after multiple ketamine injections in late postnatal mice
Journal of Anesthesia November 24, 2020
Infant isoflurane exposure affects social behaviours, but does not impair specific cognitive domains in juvenile non-human primates
British Journal of Anaesthesia November 13, 2020
The differential effects of isoflurane and sevoflurane on neonatal mice
Scientific Reports November 9, 2020
Anesthesia in Childhood and Neurodevelopmental Outcome: The Ongoing Hunt for a Phenome
Anesthesiology November 2020
Hot Topics in Safety for Pediatric Anesthesia
Children November 2020
Neuroprotection of the Developing Brain by Dexmedetomidine Is Mediated by Attenuating Single Propofol-induced Hippocampal Apoptosis and Synaptic Plasticity Deficits
Experimental Neurobiology October 31, 2020
Behavior and Regional Cortical BOLD Signal Fluctuations Are Altered in Adult Rabbits After Neonatal Volatile Anesthetic Exposure
Frontiers in Neuroscience October 23, 2020
miR-455-3p alleviates propofol-induced neurotoxicity by reducing EphA4 expression in developing neurons
Biomarkers October 18, 2020
An Overview on the Mechanisms of Neuroprotection and Neurotoxicity of Isoflurane and Sevoflurane in Experimental Studies
Brain Research Bulletin October 17, 2020
MicroRNA-204-5p mediates sevoflurane-induced cytotoxicity in HT22 cells by targeting brain-derived neurotrophic factor
Histology & Histopathology October 2, 2020
Androgenic Modulation of the Chloride Transporter NKCC1 Contributes to Age-dependent Isoflurane Neurotoxicity in Male Rats
Anesthesiology October 1, 2020
A Methyltransferase Inhibitor (Decitabine) Alleviates Intergenerational Effects of Paternal Neonatal Exposure to Anesthesia With Sevoflurane
Anesthesia & Analgesia October 2020
Sevoflurane leads to learning and memory dysfunction via breaking the balance of tPA/PAI-1.
Neurochemistry International October 2020
Maternal sevoflurane exposure affects differentiation of hippocampal neural stem cells by regulating miR-410-3p and ATN1
Stem Cell Research & Therapy September 29, 2020
Anesthesia plus surgery in neonatal period impairs preference for social novelty in mice at the juvenile age.
Biochemical and Biophysical Research Communications September 24, 2020
Protective role of protocatechuic acid in sevoflurane-induced neuron apoptosis, inflammation and oxidative stress in mice
Restorative Neurology and Neuroscience September 24, 2020
Conditions requiring hospitalisations, more than general anaesthesia itself, are associated with diagnosis of learning disorders in children
Anaesthesia Critical Care & Pain Medicine September 23, 2020
Effects of early postnatal sevoflurane exposure on oligodendrocyte maturation and myelination in cerebral white matter of the rat
Biomedicine & Pharmacotherapy September 18, 2020
Neonatal exposure to sevoflurane expands the window of vulnerability to adverse effects of subsequent exposure to sevoflurane and alters hippocampal morphology via decitabine-sensitive mechanisms
Neuroscience Letters September 14, 2020
Sevoflurane Post-Conditioning Ameliorates Neuronal Deficits and Axon Demyelination After Neonatal Hypoxic Ischemic Brain Injury: Role of Microglia/Macrophage
Cellular and Molecular Neurobiology September 2, 2020
Propofol inhibits the expression of Abelson nonreceptor tyrosine kinase without affecting learning or memory function in neonatal rats
Brain and Behavior September 1, 2020
Is Anesthesia Bad for the Brain? Current Knowledge on the Impact of Anesthetics on the Developing Brain.
Anesthesiology Clinics September 2020
Sevoflurane Induces Hippocampal Neuronal Apoptosis by Altering the Level of Neuropeptide Y in Neonatal Rats.
Neurochemical Research September 2020
Tau Contributes to Sevoflurane-induced Neurocognitive Impairment in Neonatal Mice
Anesthesiology September 2020
The Unspoken Question!
Anesthesia & Analgesia September 2020
Yes‑associated protein protects and rescues SH‑SY5Y cells from ketamine‑induced apoptosis
Molecular Medicine Reports September 2020
Propofol Exposure Disturbs the Differentiation of Rodent Neural Stem Cells via an miR-124-3p/Sp1/Cdkn1b Axis
Frontiers in Cell and Developmental Biology August 27, 2020
Dexmedetomidine: What’s New for Pediatrics? A Narrative Review
Journal of Clinical Medicine August 24, 2020
Dusp4 Contributes to Anesthesia Neurotoxicity via Mediated Neural Differentiation in Primates
Frontiers in Cell and Developmental Biology August 19, 2020
Research progress and treatment strategies for anesthetic neurotoxicity.
Brain Research Bulletin August 13, 2020
Anesthesia Exposure during Therapy Predicts Neurocognitive Outcomes in Survivors of Childhood Medulloblastoma
The Journal of Pediatrics August 2020
Sevoflurane Induces Learning and Memory Impairment in Young Mice Through a Reduction in Neuronal Glucose Transporter 3
Cellular and Molecular Neurobiology August 2020
Regions of the basal ganglia and primary olfactory system are most sensitive to neurodegeneration after extended sevoflurane anesthesia in the perinatal rat.
Neurotoxicology and Teratology July-August 2020
Association between surgical procedures under general anesthesia in infancy and developmental outcomes at 1 year: the Japan Environment and Children’s Study.
Environmental Health and Preventive Medicine July 25, 2020
LncRNA Rik-203 Contributes to Sevoflurane Induced Neurotoxicity?
Frontiers in Medicine (Lausanne) July 22, 2020
Increasing the interval between repeated anesthetic exposures reduces long‐lasting synaptic changes in late post‐natal mice
Journal of Neurochemistry July 8, 2020
Coenzyme Q10 Alleviates sevoflurane‑induced Neuroinflammation by Regulating the Levels of Apolipoprotein E and Phosphorylated Tau Protein in Mouse Hippocampal Neurons
Molecular Medicine Reports July 2020
Neurotoxicity effects of anesthetic exposure on the developing brain of non-human primates
Medical Hypotheses July 2020
LncRNA LINC00641 Sponges miR-497-5p to Ameliorate Neural Injury Induced by Anesthesia via Up-Regulating BDNF.
Frontiers in Molecular Neuroscience June 30, 2020
General anesthesia affecting on developing brain: evidence from animal to clinical research.
Journal of Anesthesia June 29, 2020
Autophagic Network Analysis of the Dual Effect of Sevoflurane on Neurons Associated with GABARAPL1 and 2.
BioMed Research International June 26, 2020
Dexmedetomidine in children – when should we be using it?
Anaesthesia June 24, 2020
Neonatal sevoflurane exposure induces impulsive behavioral deficit through disrupting excitatory neurons in the medial prefrontal cortex in mice.
Translational Psychiatry June 20, 2020
An appropriate level of autophagy reduces emulsified isoflurane-induced apoptosis in fetal neural stem cells.
Neural Regeneration Research June 19, 2020
Safety of anesthetic exposure on the developing brain – Do we have the answer yet?
Journal of Anaesthesiology Clinical Pharmacology June 15, 2020
Propofol Attenuates Isoflurane-Induced Neurotoxicity and Cognitive Impairment in Fetal and Offspring Mice
Anesthesia & Analgesia June 10, 2020
Use of Dexmedetomidine and Opioids as the Primary Anesthetic in Infants and Young Children: A Retrospective Cohort Study
Pediatric Anesthesia June 8, 2020
Optimization of Ultrasound Backscatter Spectroscopy to Assess Neurotoxic Effects of Anesthesia in the Newborn Non-human Primate Brain
Ultrasound in Medicine and Biology May 29, 2020
Neonatal Exposure to Anesthesia Leads to Cognitive Deficits in Old Age: Prevention With Intranasal Administration of Insulin in Mice
Neurotoxicity Research May 26, 2020
Neonatal Ketamine Alters High-Frequency Oscillations and Synaptic Plasticity in the Subiculum But Does not Affect Sleep Macrostructure in Adolescent Rats
Frontiers in Systems Neuroscience May 26, 2020
Neuroendocrine, epigenetic, and intergenerational effects of general anesthetics
World Journal of Psychiatry May 19, 2020
Upregulation of miR-215 attenuates propofol-induced apoptosis and oxidative stress in developing neurons by targeting LATS2.
Molecular Medicine May 6, 2020
Neurotoxicity of Sub-Anesthetic Doses of Sevoflurane and Dexmedetomidine Co-Administration in Neonatal Rats
NeuroToxicology May 5, 2020
Upregulation of miR-496 Rescues Propofol-Induced Neurotoxicity by Targeting Rho Associated Coiled-Coil Containing Protein Kinase 2 (ROCK2) in Prefrontal Cortical Neurons
Current Neurovascular Research May 5, 2020
Acetyl-l-carnitine Does Not Prevent Neurodegeneration in a Rodent Model of Prolonged Neonatal Anesthesia
Neurotoxicology and Teratology May 3, 2020
Standards for Preclinical Research and Publications in Developmental Anaesthetic Neurotoxicity: Expert Opinion Statement From the SmartTots Preclinical Working Group
British Journal of Anaesthesia May 2020
What is SmartTots?
What is the National Center for Toxicological Research (NCTR)?
How did the concerns about the safety of anesthetic drugs for infants and young children arise?
IARS 2015 Annual Meeting and International Science Symposium
Improving Health through Discovery and Education
Neurotoxicity of Anesthetics in the Developing Brain – A Translational Update
Ansgar Brambrink, MD, PhD
Key Summary Points
Neurotoxicity of Anesthetics in the Developing Brain
- The major excitatory neurotransmitter, glutamate, and the major inhibitory neurotransmitter, gamma-aminobutyric acid (GABA), are generally associated with neuronal communication in the adult brain.
- In the developing brain, these transmitters play a central role in brain morphogenesis, including synapse formation, proliferation, migration, differentiation and survival of neurons.