The possibility that exposure to general anesthetics during early life results in long-term impairment of neural function attracted considerable interest over the past decade. Extensive laboratory data suggest that administration of these drugs during critical stages of central nervous system development can lead to cell death, impaired neurogenesis, and synaptic growth as well as cognitive deficits. These observations are corroborated by several recent human epidemiological studies arguing that such cognitive impairment might also occur in humans.
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- Perinatal and neonatal use of sedation and analgesia
- More than 3 hours and less than 3 years: Safety of anaesthetic procedures in infants less than 3 years old subjected to surgery for more the 3 hours
- Ionizing radiation from computed tomography versus anesthesia for magnetic resonance imaging in infants and children: patient safety considerations
- Pediatric Anesthesia Considerations for Interventional Radiology