The possibility that exposure to general anesthetics during early life results in long-term impairment of neural function attracted considerable interest over the past decade. Extensive laboratory data suggest that administration of these drugs during critical stages of central nervous system development can lead to cell death, impaired neurogenesis, and synaptic growth as well as cognitive deficits. These observations are corroborated by several recent human epidemiological studies arguing that such cognitive impairment might also occur in humans.
- Cyclophilin D Contributes to Anesthesia Neurotoxicity in the Developing Brain
- Evaluation of the Toxicity of Sugammadex in Zebrafish Larvae
- Potential Neurodevelopmental Effects of Pediatric Intensive Care Sedation and Analgesia: Repetitive Benzodiazepine and Opioid Exposure Alters Expression of Glial and Synaptic Proteins in Juvenile Rats
- Sevoflurane inhibits neuronal migration and axon growth in the developing mouse cerebral cortex
- Iron overload contributes to general anaesthesia-induced neurotoxicity and cognitive deficits