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National Center for Toxicological Research (NCTR)

by SmartTots | Jun 1, 2022 | Research Articles

FDA’s National Center for Toxicological Research (NCTR) is conducting non-clinical studies in both rodents and nonhuman primates to assess: 1) the mechanisms underlying the neurotoxicity associated with clinically-relevant general anesthetics such as ketamine,...

Pediatric Anesthesia NeuroDevelopment Assessment (PANDA Study)

by SmartTots | Feb 1, 2022 | Research Articles

The Pediatric Anesthesia & Neurodevelopment Assessment (PANDA) project is a large, multi-center study based at the Morgan Stanley Children’s Hospital of New York (Columbia University). The project aims to examine two groups of children – those who have been...

Mayo Clinic Research: MASK (Mayo Safety in Kids) Study

by SmartTots | Jul 1, 2021 | Research Articles

Researchers at the Mayo Clinic in collaboration with the National Center for Toxicological Research (NCTR) are conducting a population-based study of long-term cognitive development in a large cohort of Rochester, MN children. The study compares performance of...

SmartTots Panel on Pediatric Anesthesia Neurotoxicity Research

by SmartTots | May 23, 2021 | Research Articles

Moderated by SmartTots Medical Officer, Dean Andropoulos, MD Pre-Clinical Research: What are the priorities? Laszlo Vutskits, MD, PhD Challenges with Clinical Studies and Update on the T-REX Trial -Andrew Davidson, MBBS, MD, FANZCA Clinical Anesthetic Neurotoxicity:...

Anesthesia and Neurotoxicity Study Design, Execution, and Reporting in the Non-Human Primate: A Deep Dive

by SmartTots | May 23, 2021 | Research Articles

Feng Gao, MD, Investigator Baylor College of Medicine What is the quality of non-human primate (NHP) studies used to support the concern for anesthesia-related neurodevelopmental delays in children? This poster session describes a systematic review of 18 manuscripts...
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Recent Posts

  • Update on SmartTots Initiative and Research Funding on April 16, 2023
  • Comparer Pommes et Oranges: Perils of Translating Rodent Studies to Human Outcomes
  • Repeated sevoflurane exposures inhibit neurogenesis by inducing the upregulation of glutamate transporter 1 in astrocytes.
  • The propofol-induced mitochondrial damage in fetal rat hippocampal neurons via the AMPK/P53 signaling pathway.
  • Ketamine modulates neural stem cell differentiation by regulating TRPC3 expression through the GSK3β/β-catenin pathway.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

90 New Montgomery Street
Suite 412
San Francisco, CA 94105
Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

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SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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