by SmartTots | Jun 1, 2022 | Research Articles
FDA’s National Center for Toxicological Research (NCTR) is conducting non-clinical studies in both rodents and nonhuman primates to assess: 1) the mechanisms underlying the neurotoxicity associated with clinically-relevant general anesthetics such as ketamine,...
by SmartTots | May 23, 2021 | Research Articles
Moderated by SmartTots Medical Officer, Dean Andropoulos, MD Pre-Clinical Research: What are the priorities? Laszlo Vutskits, MD, PhD Challenges with Clinical Studies and Update on the T-REX Trial -Andrew Davidson, MBBS, MD, FANZCA Clinical Anesthetic Neurotoxicity:...
by SmartTots | May 23, 2021 | Research Articles
Feng Gao, MD, Investigator Baylor College of Medicine What is the quality of non-human primate (NHP) studies used to support the concern for anesthesia-related neurodevelopmental delays in children? This poster session describes a systematic review of 18 manuscripts...
by SmartTots | May 23, 2021 | Research Articles
Arsène Pinguelo, Ph.D. candidate University of Toronto Using cortical astrocytes and hippocampal neurons from fetal mice, investigators explore mechanisms that raise inhibitory tonic current (surface expression) linked to post-anesthetic cognitive deficits generated...
by SmartTots | May 1, 2021 | Research Articles
Abstract Background Both animal and retrospective human studies have linked extended and repeated general anaesthesia during early development with cognitive and behavioural deficits later in life. However, the neuronal circuit mechanisms underlying this...
