Over the past decade, a large body of evidence has suggested that there may be an association between anesthesia exposure and neurocognitive deficits in children. The majority of data are derived from animal studies, but some human studies support an association between single or multiple anesthesia exposures in young children and cognitive deficits.1 With the exception of a recent prospective study and a recent ambidirectional study,2,3 human studies are limited to retrospective cohort studies that lack adequate controls or attention to the impact of confounding variables. On December 14, 2016, the US Food and Drug Administration (FDA) issued the warning that “repeated or lengthy use of general anesthetic and sedation drugs during surgeries or procedures in children younger than 3 years or in pregnant women during their third trimester may affect the development of children’s brains.
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- Changes in sensory processing after anesthesia in toddlers.
- Caffeine Augments Anesthesia Neurotoxicity in the Fetal Macaque Brain.
- Persistent alteration in behavioural reactivity to a mild social stressor in rhesus monkeys repeatedly exposed to sevoflurane in infancy.
- A neurosteroid analogue with T-type calcium channel blocking properties is an effective hypnotic, but is not harmful to neonatal rat brain.