The development and refinement of practices for the safe administration of anesthesia to children is a major success story in modern medicine. During the past several decades, there have been significant improvements in safety standards, cardiopulmonary monitoring, delivery systems, and airway management specific to the pediatric patient undergoing anesthesia. Millions of children receive anesthesia each year for surgical, procedural, or diagnostic purposes, and the majority of these patients receive a general anesthetic.
- A holistic approach to anesthesia-induced neurotoxicity and its implications for future mechanistic studies
- Sevoflurane decreases self-renewal capacity and causes c-Jun N-terminal kinase-mediated damage of rat fetal neural stem cells
- Minimally invasive biomarkers of general anesthetic-induced developmental neurotoxicity
- Neonatal inhibition of Na+-K+-2Cl−-cotransporter prevents ketamine induced spatial learning and memory impairments
- Isoflurane exposure leads to apoptosis of neurons and oligodendrocytes in 20- and 40-day old rhesus macaques