In the section of “Developmental Neurotoxicity: An Update” of the Pediatric Anesthesia Neurodevelopmental Assessment (PANDA) symposium 2018 the speakers presented the current literature in translational and clinical research. Dr. Brambrink spoke about translational research in anesthetic neurotoxicity, beginning with discovery in the rodent model, then focusing on evidence from nonhuman primates. Dr. Waspe applied the methodology of Adverse Outcome Pathways from the field of toxicology to developmental neurotoxicity of anesthetics. Dr. O’Leary presented relevant clinical studies that were published in 2017 divided by a focus on academic performance, clinical outcomes or diagnoses, or neuropsychological testing.
- SmartTots Panel on Pediatric Anesthesia Neurotoxicity Research
- Anesthesia and Neurotoxicity Study Design, Execution, and Reporting in the Non-Human Primate: A Deep Dive
- Anesthetic activation of GABAA receptors in astrocytes trigger a persistent increase in cell-surface expression of α5GABAA receptors in neurons via IL-1β in mice
- Behavioural impairments after exposure of neonatal mice to propofol are accompanied by reductions in neuronal activity in cortical circuitry.
- Protective Effect of GM1 Attenuates Hippocampus and Cortex Apoptosis After Ketamine Exposure in Neonatal Rat via PI3K/AKT/GSK3β Pathway.