Two major literature review articles and three editorials by experts on the effects of anesthesia in the developing brain were published in a recent issue of Anesthesiology, the peer-reviewed medical journal of the American Society of Anesthesiologists (ASA), to address a warning issued by the U.S. Food and Drug Administration (FDA) in December 2016 noting that repeated or lengthy use of general anesthesia and sedation drugs may affect the development of children’s brains. The warning was based primarily on results from studies of laboratory animals that may not translate to humans.
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- Dexmedetomidine attenuates ethanol-induced inhibition of hippocampal neurogenesis in neonatal mice
- miR-455-3p alleviates propofol-induced neurotoxicity by reducing EphA4 expression in developing neurons
- Propofol inhibits the expression of Abelson nonreceptor tyrosine kinase without affecting learning or memory function in neonatal rats
- MicroRNA-204-5p mediates sevoflurane-induced cytotoxicity in HT22 cells by targeting brain-derived neurotrophic factor