Two major literature review articles and three editorials by experts on the effects of anesthesia in the developing brain were published in a recent issue of Anesthesiology, the peer-reviewed medical journal of the American Society of Anesthesiologists (ASA), to address a warning issued by the U.S. Food and Drug Administration (FDA) in December 2016 noting that repeated or lengthy use of general anesthesia and sedation drugs may affect the development of children’s brains. The warning was based primarily on results from studies of laboratory animals that may not translate to humans.
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- Pack your bags, we’re going to Montreal!
- Neurodevelopmental effects of anesthesia and environmental factors
- Role of environmental stressors in determining the developmental outcome of neonatal anesthesia
- Insufficient Astrocyte-Derived Brain-Derived Neurotrophic Factor Contributes to Propofol-Induced Neuron Death through Akt/Glycogen Synthase Kinase 3β/Mitochondrial Fission Pathway
- Early Developmental Exposure to General Anesthetic Agents in Primary Neuron Culture Disrupts Synapse Formation via Actions on the mTOR Pathway