Researchers at the Mayo Clinic in collaboration with the National Center for Toxicological Research (NCTR) are conducting a population-based study of long-term cognitive development in a large cohort of Rochester, MN children. The study compares performance of children with no anesthetic exposure to those with single or multiple exposures prior to age three years on an extensive battery of neurocognitive tests including the operant test battery (OTB). Researchers at NCTR and Arkansas Children’s Hospital are using the OTB to evaluate cognitive performance in both children and non-human primates.
- Neurotoxicity of Inhalation Anesthetics in the Neonatal Rat Brain: Effects on Behavior and Neurodegeneration in the Piriform Cortex.
- Does pediatric anesthesia cause brain damage? Addressing parental and provider concerns in light of compelling animal studies and seemingly ambivalent human data.
- The postoperative effect of sevoflurane inhalational anesthesia on cognitive function and inflammatory response of pediatric patients.
- General anesthetics and cytotoxicity: possible implications for brain health.
- Update on developmental anesthesia neurotoxicity.