News and EventsSmartTots and IARS News, Press Releases and Events
SmartTots – Perspectives from the Front Lines
Millions of children undergo surgery annually. Recent studies suggest there may be reason for concern. This video, featuring Dr. Dean Andropoulos, Dr. Peter Davis, and Dr. Caleb Ing, provides a summary as to why research is needed and the type that is needed.
SmartTots to Help Make Anesthetics and Sedatives Safer for Children
Dr. Janet Woodcock, director of the Center for Drug Evaluation and Research at the Food and Drug Administration, and Dr. Michael Roizen, of the International Anesthesia Research Society, unveil a new partnership that aims to make anesthesia safer for children.
Pediatric Anesthesia Questions and Myths-Mayo Clinic
Dr. Randall Flick at Mayo Clinic “debunks myths” and answers common questions raised by parents in regard to anesthesia.
Pharmacological inhibition of PTEN attenuates cognitive deficits caused by neonatal repeated exposures to isoflurane via inhibition of NR2B-mediated tau phosphorylation in rats
Abstract Evidence has shown that children exposed to repeated anesthesia in early childhood display long-term cognitive disabilities. However, the underlying mechanisms remain largely unclear. Our previous study has indicated the involvement of phosphatase and tensin...
Repeated or lengthy use of general anesthetic and sedation drugs in infants, toddlers and pregnant women in their third trimester might damage children’s developing brains, the U.S. Food and Drug Administration warned this month. Upset that the warning about pregnant...
Children’s hospitals across Canada are advising parents not to delay necessary surgeries out of fears raised by a U.S. Food and Drug Administration warning that repeated or lengthy exposure to general anesthesia may harm brain development in children under 3. The FDA...
Repeated or lengthy use — longer than three hours — of general anesthetic and sedation drugs may harm the developing brains of fetuses and children younger than 3 years old, the U.S. Food and Drug Administration warned Wednesday. After reviewing the latest published...
For more than 15 years, the potential for lasting neurotoxic effects of agents used to induce general anesthesia and sedation when administered to young children — and indirectly through pregnant women to fetuses with developing brains — has been a subject of concern...
Neonatal anesthetic neurotoxicity: Insight into the molecular mechanisms of long-term neurocognitive deficits
Abstract Mounting animal studies have demonstrated that almost all the clinically used general anesthetics could induce widespread neuroapoptosis in the immature brain. Alarmingly, some published findings have reported long-term neurocognitive deficits in response to...
In the Media
A Less Risky Anesthesia for Babies
- SmartTots Urges Continued Research on Possible Effects of Anesthesia on Young Children; Issues Supplement to Recent Consensus Statement
- Anesthetic-Related Neurotoxicity in Children – ASA Works in Close Cooperation With FDA and Others to Advance Research