News and Events
SmartTots and IARS News, Press Releases and EventsPanda Symposium
SmartTots – Perspectives from the Front Lines
Millions of children undergo surgery annually. Recent studies suggest there may be reason for concern. This video, featuring Dr. Dean Andropoulos, Dr. Peter Davis, and Dr. Caleb Ing, provides a summary as to why research is needed and the type that is needed.
SmartTots to Help Make Anesthetics and Sedatives Safer for Children
Dr. Janet Woodcock, director of the Center for Drug Evaluation and Research at the Food and Drug Administration, and Dr. Michael Roizen, of the International Anesthesia Research Society, unveil a new partnership that aims to make anesthesia safer for children.
Pediatric Anesthesia Questions and Myths-Mayo Clinic
Dr. Randall Flick at Mayo Clinic “debunks myths” and answers common questions raised by parents in regard to anesthesia.
Mayo Clinic Study Adds Valuable Knowledge to Body of Research on Pediatric Anesthesia
A Mayo Clinic study of children who received one or more exposures to anesthesia before the age of 3 has provided valuable information about the potential neurological and behavioral impact of general anesthesia on very young children.
SmartTots Update Regarding Anesthetic Neurotoxicity in the Developing Brain
Abstract SmartTots (http://smarttots.org/) represents a public–private partnership between the International Anesthesia Research Society and the US Food and Drug Administration. Over the past 7 years, SmartTots has worked in collaboration with various stakeholders to...
SmartTots: Quo Vadis?
Few if any issues received more attention in the field of pediatric perioperative care over the past decade than developmental anesthesia neurotoxicity. While the possibility of a plausible association between anesthesia and postoperative personality changes in...
Epidemiology of Exposure to Anesthesia, Surgery, and Mortality in a Children’s Hospital Population
Advances in anesthesia and surgery enable children to receive anesthesia with relative safety. Recently, young age, prolonged, and multiple anesthetics have been highlighted as risk factors for poorer neurodevelopmental outcome, with neurotoxicity of anesthetic agents as a putative causal link. Because epidemiologic studies cannot fully disentangle patient factors associated with outcome, questions persist about causality, and neurodevelopmental attainment may be a health outcome with multiple genetic, social, and physiologic determinants.
Effects of short-term exposure to sevoflurane on the survival, proliferation, apoptosis, and differentiation of neural precursor cells derived from human embryonic stem cells.
Data from animal experiments suggest that exposure to general anesthetics in early life inhibits neurogenesis and causes long-term memory deficit. Considering short operating times and the popularity of sevoflurane in pediatric anesthesia, it is important to verify the effects of short-period exposure to sevoflurane on the developing brain.
Emulsified isoflurane induces release of cytochrome C in human neuroblastoma SHSY-5Y cells via JNK (c-Jun N-terminal kinases) signaling pathway.
A large number of studies have demonstrated that inhalation anesthetic isoflurane induced neural cell death by apoptosis in various cell and animal models. Emulsified isoflurane (EIso) is a new type of intravenous preparation of isoflurane that attracts increasing research attention as a promising clinical agent due to its both advantages as an intravenous and inhalation anesthetics medication. However, its safety and underlying molecular mechanism of neurotoxicity largely remain unknown.