Abstract
Sevoflurane is one of the most commonly used volatile anaesthetics in general anaesthesia in children. Sevoflurane anaesthesia (2–2.5% for 4–6 h) can cause neuronal apoptosis and long-term learning and memory impairment in multiple brain regions of neonatal rats. Therefore, it is necessary to study the acute and chronic mechanism of general anaesthetic-induced brain developmental injury. This study examined the changes in nectin-1 after exposure to sevoflurane in newborn mice in the hippocampal CA3 area.