Millions of babies and children undergo anaesthesia every year. Preclinical evidence shows that all common anaesthetic drugs are associated with neuro-apoptosis and neurodevelopmental deficits in immature rodent models. Xenon, a low-potency anaesthetic gas, renowned for producing cardiostable anaesthesia and with neuroprotective properties in multiple pathologies, was recently used to reduce sevoflurane requirements of babies and young children undergoing cardiac catheterisation. Preclinical studies have shown the addition of xenon reduced neuroapoptosis induced by 0.7% isoflurane in vivo and in vitro.
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- Cell cycle activation contributes to isoflurane-induced neurotoxicity in the developing brain and the protective effect of CR8.
- Protective Effects of Xenon on Propofol-Induced Neurotoxicity in Human Neural Stem Cell-Derived Models.
- Neonatal exposure to propofol affects interneuron development in the piriform cortex and causes neurobehavioral deficits in adult mice.
- The expression of glucose transporters and mitochondrial division and fusion proteins in rats exposed to hypoxic preconditioning to attenuate propofol neurotoxicity.
- Inhibition of microRNA-375 ameliorated ketamine-induced neurotoxicity in human embryonic stem cell derived neurons.