The possibility that exposure to general anesthetics during early life results in long-term impairment of neural function attracted considerable interest over the past decade. Extensive laboratory data suggest that administration of these drugs during critical stages of central nervous system development can lead to cell death, impaired neurogenesis, and synaptic growth as well as cognitive deficits. These observations are corroborated by several recent human epidemiological studies arguing that such cognitive impairment might also occur in humans.
- Overexpression of lncRNA Gm15621 alleviates apoptosis and inflammation response resulting from sevoflurane treatment through inhibiting miR-133a/Sox4.
- Role of autophagy in sevoflurane-induced neurotoxicity in neonatal rat hippocampal cells.
- The positive allosteric modulation of GABAA receptors mRNA in immature hippocampal rat neurons by midazolam affects receptor expression and induces apoptosis.
- Euxanthone Ameliorates Sevoflurane-Induced Neurotoxicity in Neonatal Mice.
- Toxicity mechanism of sevoflurane in neural stem cells of rats through DNA methylation.