Over the past decade, a large body of evidence has suggested that there may be an association between anesthesia exposure and neurocognitive deficits in children. The majority of data are derived from animal studies, but some human studies support an association between single or multiple anesthesia exposures in young children and cognitive deficits.1 With the exception of a recent prospective study and a recent ambidirectional study,2,3 human studies are limited to retrospective cohort studies that lack adequate controls or attention to the impact of confounding variables. On December 14, 2016, the US Food and Drug Administration (FDA) issued the warning that “repeated or lengthy use of general anesthetic and sedation drugs during surgeries or procedures in children younger than 3 years or in pregnant women during their third trimester may affect the development of children’s brains.
- Neonatal Isoflurane Anesthesia or Disruption of Postsynaptic Density-95 Protein Interactions Change Dendritic Spine Densities and Cognitive Function in Juvenile Mice.
- Autophagic Network Analysis of the Dual Effect of Sevoflurane on Neurons Associated with GABARAPL1 and 2.
- Effects of ketamine on neurogenesis, extracellular matrix homeostasis and proliferation in hypoxia-exposed HT22 murine hippocampal neurons.
- LncRNA Rik-203 Contributes to Sevoflurane Induced Neurotoxicity?
- Upregulation of miR-215 attenuates propofol-induced apoptosis and oxidative stress in developing neurons by targeting LATS2.