by SmartTots | Aug 31, 2023 | Clinical Articles, Research Articles
Abstract Background: Multiple human studies have shown no significant long-term results of anesthesia exposure during early childhood compared to the general population; however, reports on short-term neurodevelopmental assessment before and after anesthesia exposure...
by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract Objectives: Isoflurane (ISO) is widely used in the clinic and research. The authors aimed to explore whether Neobaicalein (Neob) could protect neonatal mice from ISO-induced cognitive damage. Method: The open field test, Morris water maze test, and tail...
by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract Impaired cerebellar development of premature infants and the associated impairment of cerebellar functions in cognitive development could be crucial factors for neurodevelopmental disorders. Anesthetic- and hyperoxia-induced neurotoxicity of the immature...
by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract Anesthetics such as sevoflurane are commonly administered to infants and children. However, the possible neurotoxicity caused by prolonged or repetitive exposure to it should be a concern. The neuroprotective effects of metformin are observed in many models...
by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract Propofol is neurotoxic to trigger neuronal pyroptosis and dexmedetomidine possesses the ability to suppress proptosis. This study expounded on the protective functions of dexmedetomidine on propofol-induced pyroptosis of primary hippocampal neurons via...
