by SmartTots | May 1, 2023 | Preclinical Articles, Research Articles
Abstract Background: Sevoflurane is an inhalational anesthetic for the induction and maintenance of general anesthesia in pediatric surgery. However, few studies have paid attention to the multiple organ toxicity and the mechanism behind it. Methods: Inhalation...
by SmartTots | May 1, 2023 | Preclinical Articles, Research Articles
Abstract An increasing number of studies reveal the deleterious effects of isoflurane (Iso) exposure during pregnancy on offspring cognition. However, no effective therapeutic strategy for Iso-induced deleterious effects has been well developed. Angelicin exerts an...
by SmartTots | May 1, 2023 | Preclinical Articles, Research Articles
Abstract Sevoflurane (Sevo) is one of the most commonly used general anesthetics for infants and young children. We investigated whether Sevo impairs neurological functions, myelination, and cognition via the γ-aminobutyric acid A receptor (GABAAR) and...
by SmartTots | May 1, 2023 | Preclinical Articles, Research Articles
Abstract Background: The anesthetic isoflurane can cause neurotoxicity in fetuses and offspring of rats, affecting their neurodevelopment. However, the underlying mechanisms and therapeutic targets of isoflurane-induced neurotoxicity remain to be identified....
