by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract Introduction: The development and maintenance of neural circuits is highly sensitive to neural activity. General anesthetics have profound effects on neural activity and, as such, there is concern that these agents may alter cellular integrity and interfere...
by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract Exposure to commonly used anesthetics leads to neurotoxic effects in animal models-ranging from cell death to learning and memory deficits. These neurotoxic effects invoke a variety of molecular pathways, exerting either immediate or long-term effects at the...
by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract The early developing brain is especially vulnerable to anesthesia, which can result in long lasting functional changes. We examined the effects of early-life propofol on adult excitatory-inhibitory balance and behavior. Postnatal day 7 male mice were exposed...
by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract Zebrafish is known for its widespread neurogenesis and regenerative capacity, as well as several biological advantages, which turned it into a relevant animal model in several areas of research, namely in toxicological studies. Ketamine is a well-known...
by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract General anaesthetics (GA) have been in continuous clinical use for more than 170 years, with millions of young and elderly populations exposed to GA to relieve perioperative discomfort and carry out invasive examinations. Preclinical studies have shown that...
