by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract Objective: Dexmedetomidine use decreases adverse neurocognitive outcomes in adults undergoing cardiovascular surgery, but its effect has been unclear in children with congenital heart disease. Methods: The authors conducted a systematic review using the...
by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract Surgery and anesthesia in neonates may lead to cognitive impairment or abnormal behaviors. It has been shown that autophagy plays a critical role in neuropsychiatric disorders, while the role of autophagy in postoperative cognitive impairment in neonates is...
by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract Neurologic morbidity is highly prevalent in pediatric critical illness, and the use of benzodiazepines and/or opioids is a risk factor for delirium and post-discharge sequelae. However, little is known about how multidrug sedation with these medications...
by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract Ketamine, a noncompetitive N-methyl D-aspartate (NMDA) receptor antagonist, is widely used in pediatric clinical practice. The neuroprotective and neurotoxic effects of ketamine on brain neurons during development remain controversial. The reason may be...
by SmartTots | Jun 28, 2023 | Preclinical Articles, Research Articles
Abstract Aims: Mid-gestational sevoflurane exposure may induce notable long-term neurocognitive impairment in offspring. This study was designed to investigate the role and potential mechanism of ferroptosis in developmental neurotoxicity induced by sevoflurane in the...
