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Propofol-Induced Developmental Neurotoxicity: From Mechanisms to Therapeutic Strategies.

by SmartTots | May 1, 2023 | Preclinical Articles, Research Articles

Abstract Propofol is the most commonly used intravenous general anesthetic in clinical anesthesia, and it is also widely used in general anesthesia for pregnant women and infants. Some clinical and preclinical studies have found that propofol causes damage to the...

Prenatal anesthetic exposure and offspring neurodevelopmental outcomes-A narrative review.

by SmartTots | May 1, 2023 | Clinical Articles, Research Articles

Abstract While it is common for pregnant women to take anesthesia during surgery, the effects of prenatal anesthesia exposure (PAE) on the long-term neurodevelopment of the offspring remain to be clarified. Preclinical animal research has shown that in...

Age-Stratified Propofol Dosage for Pediatric Procedural Sedation and Analgesia.

by SmartTots | May 1, 2023 | Clinical Articles, Research Articles

Abstract Background: Procedural sedation and analgesia (PSA) for diagnostic and minimally invasive therapeutic procedures has become common practice in children of all ages. Based on our clinical experience, we suspected an inverse relation between age and dosage....

Comparative Sedation with Sevoflurane and Thiopental in Children Undergoing MR Imaging.

by SmartTots | May 1, 2023 | Clinical Articles, Research Articles

Abstract Objective: To compare the use of propofol and thiopental in children undergoing MRI. Study design: Descriptive, comparative study. Place and duration of study: University of Health Sciences, Van Training and Research Hospital, Van, Turkey, between January 01...

Perinatal Anesthesia Exposure and Autism Spectrum Disorders.

by SmartTots | May 1, 2023 | Clinical Articles, Research Articles

Abstract Epidural analgesia is frequently used during labor among pregnant people in the United States. Different factors have been associated with the development of autism spectrum disorder in the epidemiological literature: maternal health, infectious and...
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Recent Posts

  • A Scoping Review of the Mechanisms Underlying Developmental Anesthetic Neurotoxicity
  • 2025 Annual Meeting, presented by the International Anesthesia Research Society (IARS) and the Society of Critical Care Anesthesiologists (SOCCA), March 20 – 23, 2025, Honolulu, HI
  • Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses: A Natural Experiment Using Appendectomy
  • Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN): a multicentre, open-label, randomised controlled phase 4 trial. Claire Elizabeth Wainwright, et al. June 2024
  • Columbia University Physician Scientist and SmartTots Investigator, Caleb Ing, MD, publishes new findings regarding prenatal exposure to general anesthesia and subsequent risk to the child.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

Tax Information

SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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