by SmartTots | May 1, 2023 | Clinical Articles, Research Articles
Abstract Objective: To investigate the association between exposure to surgery under general anesthesia and brain abnormalities and neurodevelopmental outcomes in very preterm infants. Study design: This prospective observational study includes 392 infants born at or...
by SmartTots | May 1, 2023 | Clinical Articles, Research Articles
Abstract Background: There are inconsistent reports regarding the association between general anesthesia and adverse neurodevelopmental and behavioral disorders in children. Methods: This nationwide administrative cohort study included children born in Korea between...
by SmartTots | Apr 28, 2023 | News
The TREX (Toxicity Remifentanil DEXmedetomidine) Trial Investigators are pleased to announce the completion of enrollment of the 450 trial subjects. The TREX Trial is a multicenter, multinational study of two anesthetic regimens for prolonged anesthesia in infants and...
by SmartTots | Apr 14, 2023 | Clinical Articles, Research Articles
Abstract Background: The effect of labor epidural anesthesia (LEA) on the risk of autism spectrum disorder (ASD) in offspring has been investigated recently, and available results are inconsistent. Methods: We searched the PubMed and EMBASE databases for relevant...
by SmartTots | Feb 14, 2023 | Preclinical Articles, Research Articles
Abstract Developmental sevoflurane exposure leads to widespread neuronal cell death known as sevoflurane-induced neurotoxicity (SIN). Receptor-interacting protein kinase-3 (RIPK3) and mixed lineage kinase domain-like (MLKL)-driven necroptosis plays an important role...
