by SmartTots | Nov 2, 2022 | Preclinical Articles, Research Articles
Abstract The profound programming effects of early life stress (ELS) on brain and behavior are thought to be primarily mediated by adrenal glucocorticoids (GCs). However, in mice, stressors are often administered between postnatal days 2 and 12 (PND2-12), during the...
by SmartTots | Nov 2, 2022 | Preclinical Articles, Research Articles
Abstract Background: Prolonged exposure to general anesthesia (GA) results in long-lasting cognitive impairment, especially during critical stages of brain development. An exaggerated neuroinflammation induced by anesthesia is generally considered to be a key cause of...
by SmartTots | Nov 2, 2022 | Preclinical Articles, Research Articles
Abstract Sevoflurane anesthesia induces neurocognitive impairment and pyroptosis in the developing brain. Pleckstrin homology-like domain, family A, member 1 (PHLDA1) was involved in neuronal apoptosis, oxidative stress and inflammation during ischemic stroke. The...
by SmartTots | Nov 2, 2022 | Preclinical Articles, Research Articles
Abstract Background: In neonatal mice, anesthesia with sevoflurane depolarizes the GABA Type A receptor (GABAAR), which leads to cognitive impairment. Calcium accumulation in neurons can lead to neurotoxicity. Voltage-gated calcium channels (VGCCs) can increase...
by SmartTots | Nov 2, 2022 | Preclinical Articles, Research Articles
Abstract Background: General anesthesia (GA) in pediatric patients represents a clinical routine. Factors such as increased birth age and maternal chronic conditions cause more infants to experience hypoxic-ischemic encephalopathy, an additional risk for anesthesia....
