by SmartTots | Apr 28, 2022 | Research Articles
Abstract Studies on rodents and nonhuman primates suggest that exposure to anesthetics, particularly in the young brain, is associated with neuronal apoptosis as well as hippocampal‑dependent cognitive dysfunction. Disruption of the development of dentate gyrus may...
by SmartTots | Apr 28, 2022 | Research Articles
Abstract Background Sevoflurane is a volatile anesthetic that is widely used in pediatric anesthesia due to its low toxicity. However, whether neonatal exposure to sevoflurane induces long-lasting cognitive impairment remains unclear. It has reported that neuronal...
by SmartTots | Apr 28, 2022 | Research Articles
Abstract General anesthetics are capable of inducing neuronal apoptosis during the rapid synaptogenesis of immature mammalian brains. In this vulnerable time window, physiological apoptosis also occurs to eliminate excess and inappropriately integrated neurons. We...
by SmartTots | Apr 28, 2022 | Research Articles
Abstract Sevoflurane (Sev) is a widely used inhalational anesthetic for general anesthesia in children. Previous studies have confirmed that multiple exposures to inhaled anesthetic can induce long-term neurotoxicity in newborn mice. However, the underlying mechanisms...
by SmartTots | Apr 28, 2022 | Research Articles
Abstract Background: Isoflurane can significantly induce inflammation in children without surgical stress. The toll-like receptor 4 (TLR4) is closely related to noninfectious inflammation in the brain. Objectives: To investigate the role of TLR4-small interfering RNA...
