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Identification of microRNA/target gene in the dentate gyrus of 7 day old mice following isoflurane exposure.

by SmartTots | Apr 28, 2022 | Research Articles

Abstract Studies on rodents and nonhuman primates suggest that exposure to anesthetics, particularly in the young brain, is associated with neuronal apoptosis as well as hippocampal‑dependent cognitive dysfunction. Disruption of the development of dentate gyrus may...

Repeated neonatal exposure to sevoflurane induces age-dependent impairments in cognition and synaptic plasticity in mice.

by SmartTots | Apr 28, 2022 | Research Articles

Abstract Background Sevoflurane is a volatile anesthetic that is widely used in pediatric anesthesia due to its low toxicity. However, whether neonatal exposure to sevoflurane induces long-lasting cognitive impairment remains unclear. It has reported that neuronal...

Sevoflurane-Induced Apoptosis in the Mouse Cerebral Cortex Follows Similar Characteristics of Physiological Apoptosis.

by SmartTots | Apr 28, 2022 | Research Articles

Abstract General anesthetics are capable of inducing neuronal apoptosis during the rapid synaptogenesis of immature mammalian brains. In this vulnerable time window, physiological apoptosis also occurs to eliminate excess and inappropriately integrated neurons. We...

Sevoflurane-Induced Neurotoxicity in the Developing Hippocampus via HIPK2/AKT/mTOR Signaling.

by SmartTots | Apr 28, 2022 | Research Articles

Abstract Sevoflurane (Sev) is a widely used inhalational anesthetic for general anesthesia in children. Previous studies have confirmed that multiple exposures to inhaled anesthetic can induce long-term neurotoxicity in newborn mice. However, the underlying mechanisms...

The role and mechanism of TLR4-siRNA in the impairment of learning and memory in young mice induced by isoflurane.

by SmartTots | Apr 28, 2022 | Research Articles

Abstract Background: Isoflurane can significantly induce inflammation in children without surgical stress. The toll-like receptor 4 (TLR4) is closely related to noninfectious inflammation in the brain. Objectives: To investigate the role of TLR4-small interfering RNA...
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Recent Posts

  • Sevoflurane diminishes neurogenesis and promotes ferroptosis in embryonic prefrontal cortex via inhibiting nuclear factor-erythroid 2-related factor 2 expression.
  • Neonatal Anesthesia and Oxidative Stress.
  • LncRNA SNHG12 ameliorates bupivacaine-induced neurotoxicity by sponging miR-497-5p to upregulate NLRX1.
  • Downregulation of HOTAIR reduces neuronal pyroptosis by targeting miR-455-3p/NLRP1 axis in propofol-treated neurons in vitro.
  • MiRNA-384-5p targets GABRB1 to regulate ketamine-Induced Neurotoxicity in Neurons.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

90 New Montgomery Street
Suite 412
San Francisco, CA 94105
Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

Tax Information

SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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