by SmartTots | Feb 14, 2023 | Preclinical Articles, Research Articles
Abstract Growing animal studies suggest a risk of neuronal damage following early childhood exposure to anesthesia and sedation drugs including propofol. Inhibition of transient receptor potential canonical 6 (TRPC6) degradation has been shown to protect neurons from...
by SmartTots | Feb 14, 2023 | Preclinical Articles, Research Articles
Abstract Objective: Anaesthesia is required in 0.4-1% of pregnant women, and prolonged and repeated exposures to anaesthesia may be required. It is unknown whether these exposures may result in foetal neurotoxicity in humans. As sheep have a gestation comparable to...
by SmartTots | Feb 14, 2023 | Clinical Articles, Research Articles
Abstract Children undergoing general anesthesia and surgery in the early years of life are exposed to the possible neurotoxicity of anesthetic agents. Prospective studies have shown deficits in behavior, executive function, social communication, and motor function in...
by SmartTots | Feb 14, 2023 | Clinical Articles, Research Articles
Abstract Purpose: To evaluate the impact of clinical protocol change via active minimisation on the number of general anaesthetic (GA)/sedation episodes for diagnostic ophthalmic purposes at Children’s Health Ireland at Temple Street (CHI-TS), Dublin, Ireland,...
by SmartTots | Feb 14, 2023 | Clinical Articles, Research Articles
A recent laboratory study in the British Journal of Anaesthesia examined the effects of repeated exposures of neonatal mice to fentanyl on autism-like behaviour via opioid receptor-mediated DNA hypermethylation of the Grin2B gene, which encodes the GluN2B subunit of...
