by SmartTots | Jan 4, 2023 | Preclinical Articles, Research Articles
Abstract Sevoflurane anesthesia is reported to repress neurogenesis of neural stem cells (NSCs), thereby affecting the brain development, but the underlying mechanism of sevoflurane on the proliferation of NSCs remains unclear. Thus, this study aims to discern the...
by SmartTots | Jan 4, 2023 | Preclinical Articles, Research Articles
Abstract Repeated or prolonged early life exposure to anesthesia is neurotoxic in animals and associated with neurocognitive impairment in later life in humans. We used electron microscopy with unbiased stereological sampling to assess synaptic ultrastructure in...
by SmartTots | Jan 4, 2023 | Preclinical Articles, Research Articles
Abstract Sevoflurane inhalation is prone to initiate cognitive deficits in infants. The early growth response-2 (Egr-2) gene is DNA-binding transcription factor, involving in cognitive function. In this study we explored the molecular mechanisms underlying the...
by SmartTots | Jan 4, 2023 | Preclinical Articles, Research Articles
Abstract Repeated or prolonged, but not short-term, general anesthesia during the early postnatal period causes long-lasting impairments in memory formation in various species. The mechanisms underlying long-lasting impairment in cognitive function are poorly...
by SmartTots | Jan 4, 2023 | Preclinical Articles, Research Articles
Abstract General anesthetics-induced neurotoxicity and cognitive impairment in developing brains have become one of the current research hotspots in the medical science community. The underlying mechanisms are complex and involve various related molecular signaling...
