by SmartTots | Nov 2, 2022 | Preclinical Articles, Research Articles
Abstract Background: Developing brain is highly plastic and can be easily affected. Growing pediatric usage of anesthetics during painless procedures has raised concerns about the effect of low-dose anesthetics on neurodevelopment. It is urgent to ascertain the...
by SmartTots | Nov 2, 2022 | Preclinical Articles, Research Articles
Abstract Background: Ketamine, a non-competitive N-methyl-D-aspartate receptor (NMDAR) antagonist, is widely applicable to anesthesia, analgesia, and sedation. However, the function and mechanisms of ketamine in the long-term learning and memory function of neonatal...
by SmartTots | Nov 2, 2022 | Preclinical Articles, Research Articles
Abstract Use of the inhalation anesthetic isoflurane may increase the risk of cognitive deficiency and neurotoxicity after birth. A growing body of evidence suggests that melatonin is an effective treatment for various types of oxidative stress damage and...
by SmartTots | Nov 2, 2022 | Preclinical Articles, Research Articles
Abstract The profound programming effects of early life stress (ELS) on brain and behavior are thought to be primarily mediated by adrenal glucocorticoids (GCs). However, in mice, stressors are often administered between postnatal days 2 and 12 (PND2-12), during the...
by SmartTots | Nov 2, 2022 | Preclinical Articles, Research Articles
Abstract Background: Prolonged exposure to general anesthesia (GA) results in long-lasting cognitive impairment, especially during critical stages of brain development. An exaggerated neuroinflammation induced by anesthesia is generally considered to be a key cause of...
