by SmartTots | Nov 2, 2022 | Preclinical Articles, Research Articles
Abstract Background: Sevoflurane is one of the most popular inhalational anesthetics during perioperative period but presenting neurotoxicity among pediatric and aged populations. Recent experiments in vivo and in vitro have indicated that ferroptosis may contribute...
by SmartTots | Nov 2, 2022 | Preclinical Articles, Research Articles
Abstract As one of the commonly used inhalation anesthetics in clinical practice, sevoflurane is currently widely applied in surgery for children and the elderly due to its safety and efficacy. However, the neurotoxicity and cognitive impairment induced by sevoflurane...
by SmartTots | Nov 2, 2022 | Preclinical Articles, Research Articles
Abstract Damage to hippocampus, cerebellum, and cortex associated with cognitive functions due to anesthetic-induced toxicity early in life may cause cognitive decline later. Aquaporin 4 (AQP4), a key protein in waste clearance pathway of brain, is involved in...
by SmartTots | Nov 2, 2022 | Clinical Articles, Research Articles
Abstract Background: Electroencephalogram (EEG) discontinuity can occur at high concentrations of anesthetic drugs, reflecting suppression of electrocortical activity. This EEG pattern has been reported in children and reflects a deep state of anesthesia. Isoelectric...
by SmartTots | Nov 2, 2022 | Clinical Articles, Research Articles
Abstract Background: Infants with prenatal opioid and substance exposure are at higher risk of poor neurobehavioral outcomes in later childhood. Early brain imaging in infancy has the potential to identify early brain developmental alterations that may help predict...
