by SmartTots | Jul 21, 2022 | News
IARS is pleased to announce the funding of two new research studies totaling $309,000, aimed at addressing remaining pediatric anesthetic neurotoxicity questions. IARS, and its generous members and donors, have provided the needed funding to continue the work that...
by SmartTots | Jul 7, 2022 | Research Articles
Abstract Background: Sevoflurane, a volatile anesthetic, is known to induce widespread neuronal degeneration and apoptosis. Recently, the stress-inducible protein sestrin 2 and adenosine monophosphate-activated protein kinase (AMPK) have been found to regulate the...
by SmartTots | Jul 7, 2022 | Research Articles
Abstract Objective: Neonatal exposure to propofol has been reported to cause neurotoxicity and neurocognitive decline in adulthood; however, the underlying mechanism has not been established. Methods: SD rats were exposed to propofol on postnatal day 7 (PND-7)....
by SmartTots | Jul 7, 2022 | Research Articles
Abstract It has been widely demonstrated by numerous preclinical studies and clinical trials that the neonates receiving repeated or long-time general anesthesia (GA) could develop prolonged cognitive dysfunction. However, the definite mechanism remains largely...
by SmartTots | Jul 7, 2022 | Research Articles
Abstract Inhaled anesthetics are known to induce neurotoxicity in the developing brains of rodents, although the mechanisms are not well understood. The aim of this study was to elucidate the molecular mechanisms underlying anesthetics-induced neurodevelopmental...
