by SmartTots | Nov 3, 2023 | Preclinical Articles, Research Articles
Abstract In the last two decades, safety concerns about general anesthesia (GA) arose from studies documenting brain cell death in various pharmacological conditions and animal models. Nowadays, a thorough characterization of sevoflurane-induced apoptosis in the...
by SmartTots | Nov 3, 2023 | Preclinical Articles, Research Articles
Abstract Cognitive dysfunction induced by anesthesia in the infant is a crucial clinical issue that is still being debated and the focus of concern for the parents. However, the mechanism of cognitive decline caused by anesthesia and the corresponding treatment...
by SmartTots | Nov 3, 2023 | Preclinical Articles, Research Articles
Abstract Sevoflurane exposure during rapid brain development induces neuronal apoptosis and causes memory and cognitive deficits in neonatal mice. Exosomes that transfer genetic materials including long non-coding RNAs (lncRNAs) between cells play a critical role in...
by SmartTots | Nov 3, 2023 | Preclinical Articles, Research Articles
Abstract Background Clinical studies suggest that anaesthesia exposure early in life affects neurobehavioural development. We designed a non-human primate (NHP) study to evaluate cognitive, behavioural, and brain functional and structural alterations after isoflurane...
by SmartTots | Nov 3, 2023 | Clinical Articles, Research Articles
Abstract Purpose of review: To provide an overview of anesthetic techniques for innovative diagnostic and therapeutic epilepsy procedures performed on pediatric patients. Recent findings: Recent studies have been published on the anesthetic consideration for...
