by SmartTots | Nov 3, 2023 | Preclinical Articles, Research Articles
Abstract Propofol is one of the most used intravenous anesthetic agents, which is widely used in clinical anesthesia induction and maintenance of pediatric patients. Exposure of the developing brain to propofol has been reported to lead to adverse brain changes, which...
by SmartTots | Nov 3, 2023 | Preclinical Articles, Research Articles
Abstract In the last two decades, safety concerns about general anesthesia (GA) arose from studies documenting brain cell death in various pharmacological conditions and animal models. Nowadays, a thorough characterization of sevoflurane-induced apoptosis in the...
by SmartTots | Nov 3, 2023 | Preclinical Articles, Research Articles
Abstract Cognitive dysfunction induced by anesthesia in the infant is a crucial clinical issue that is still being debated and the focus of concern for the parents. However, the mechanism of cognitive decline caused by anesthesia and the corresponding treatment...
by SmartTots | Nov 3, 2023 | Preclinical Articles, Research Articles
Abstract Sevoflurane exposure during rapid brain development induces neuronal apoptosis and causes memory and cognitive deficits in neonatal mice. Exosomes that transfer genetic materials including long non-coding RNAs (lncRNAs) between cells play a critical role in...
by SmartTots | Nov 3, 2023 | Preclinical Articles, Research Articles
Abstract Background Clinical studies suggest that anaesthesia exposure early in life affects neurobehavioural development. We designed a non-human primate (NHP) study to evaluate cognitive, behavioural, and brain functional and structural alterations after isoflurane...
