by SmartTots | Sep 6, 2016 | Research Articles
Summary We analysed the association of independent variables with non-verbal cognition at 6 years in children with complete data (3441 from a cohort of 9901), of whom 415 were anaesthetised before the age of 5 years. Using multivariable regression, cognition was...
by SmartTots | Sep 6, 2016 | Research Articles
Abstract Pre-clinical studies have consistently found that most general anaesthetics produce accelerated apoptosis in the developing brain. The effect has been seen in species ranging from the nematode to the non-human primate. A variety of other effects are also...
by SmartTots | Sep 6, 2016 | Research Articles
Abstract BACKGROUND: Exposure to isoflurane increases apoptosis among postnatally generated hippocampal dentate granule cells. These neurons play important roles in cognition and behavior, so their permanent loss could explain deficits after surgical procedures....
by SmartTots | Sep 6, 2016 | Research Articles
Abstract Background: Animal studies demonstrate general anesthetic (GA) toxicity in the developing brain. Clinical reports raise concern, but the risk of GA exposure to neurodevelopment in children remains uncertain. Methods: The authors undertook a retrospective...
by SmartTots | Aug 31, 2016 | Research Articles
Abstract Many studies have demonstrated a neurodegenerative effect of anesthetic drugs in cubs and young animals, raising the concern that similar effects can happen in children, and that the administration of anesthesia in young children undergoing surgical or...
