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Anesthetic Neurotoxicity Meets Big Data: Reasons to Be Cheerful?

by SmartTots | Aug 6, 2016 | News

FOR more than a decade, the possibility that exposure to anesthetics may be harmful to the developing human brain has intrigued anesthesiologists and the public alike. The urgent desire to create more clarity and the need to inform parents of young children who need...

Ketamine Affects the Neurogenesis of the Hippocampal Dentate Gyrus in 7-Day-Old Rats

by SmartTots | Aug 6, 2016 | Research Articles

Abstract Ketamine has been reported to cause neonatal neurotoxicity via a neuronal apoptosis mechanism; however, no in vivo research has reported whether ketamine could affect postnatal neurogenesis in the hippocampal dentate gyrus (DG). A growing number of...

Volatile Anesthetics Transiently Disrupt Neuronal Development in Neonatal Rats

by SmartTots | Aug 6, 2016 | Research Articles

Abstract Volatile anesthetics can cause neuronal and glial toxicity in the developing mammalian brain, as well as long-term defects in learning and memory. The goals of this study were to compare anesthetics using a clinically relevant exposure paradigm, and to assess...

AAP REPORT UPDATES SAFE PRACTICES WHEN SEDATING A PEDIATRIC PATIENT

by SmartTots | Jun 29, 2016 | News

More children undergo medical and dental procedures that require sedation than in prior decades, prompting the American Academy of Pediatrics to update recommendations that provide a safety net for pediatric patients. The clinical report, “Guidelines for Monitoring...

Xenon depresses aEEG background voltage activity whilst maintaining cardiovascular stability in sedated healthy newborn pigs

by SmartTots | Jun 28, 2016 | Research Articles

Abstract BACKGROUND: Changes in electroencephalography (EEG) voltage range are used to monitor the depth of anaesthesia, as well as predict outcome after hypoxia-ischaemia in neonates. Xenon is being investigated as a potential neuroprotectant after hypoxic-ischaemic...
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Recent Posts

  • A Scoping Review of the Mechanisms Underlying Developmental Anesthetic Neurotoxicity
  • 2025 Annual Meeting, presented by the International Anesthesia Research Society (IARS) and the Society of Critical Care Anesthesiologists (SOCCA), March 20 – 23, 2025, Honolulu, HI
  • Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses: A Natural Experiment Using Appendectomy
  • Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN): a multicentre, open-label, randomised controlled phase 4 trial. Claire Elizabeth Wainwright, et al. June 2024
  • Columbia University Physician Scientist and SmartTots Investigator, Caleb Ing, MD, publishes new findings regarding prenatal exposure to general anesthesia and subsequent risk to the child.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

Tax Information

SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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