by SmartTots | Jun 28, 2016 | Research Articles
Abstract Propofol exerts a cytotoxic influence over immature neurocytes. Our previous study revealed that clinically relevant doses of propofol accelerated apoptosis of primary cultured astrocytes of developing rodent brains via rno-miR-665 regulation. However, the...
by SmartTots | Jun 28, 2016 | Research Articles
Abstract OBJECTIVES: Despite improved survival in children with hypoplastic left heart syndrome (HLHS), significant concern persists regarding their neurodevelopmental (ND) outcomes. Previous studies have identified patient factors, such as prematurity and genetic...
by SmartTots | Jun 28, 2016 | Research Articles
Abstract BACKGROUND: Concerns have risen regarding the potential side effects of clinical exposure of the pediatric population to inhalational anesthetics, and how they might impact cognitive, learning, and memory functions. However, neither the mechanisms of...
by SmartTots | Jun 28, 2016 | Research Articles
ABSTRACT BACKGROUND: Recent concerns regarding possible long-term effects of early anesthesia exposure on neurodevelopment in children have provided an impetus to explore alternative anesthetic techniques using potentially neuroprotective agents. Dexmedetomidine has...
by SmartTots | Jun 27, 2016 | Research Articles
A recent study concluded that very young, healthy children undergoing short surgical procedures requiring a single exposure to general anesthesia did not exhibit any effect on the cognitive outcomes tested, according to SmartTots, a public-private partnership of the...
