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Ketamine-Induced Toxicity in Neurons Differentiated from Neural Stem Cells

by SmartTots | Jun 9, 2015 | Research Articles

 Mol Neurobiol, June 2015.  Slikker W Jr, Liu F, Rainosek SW, Patterson TA, Sadovova N, Hanig JP, Paule MG, Wang C  Abstract  Ketamine is used as a general anesthetic, and recent data suggest that anesthetics can cause neuronal damage when exposure occurs during...

Early Exposure to General Anesthesia Disrupts Spatial Organization of Presynaptic Vesicles in Nerve Terminals of the Developing Rat Subiculum

by SmartTots | Jun 8, 2015 | Research Articles

Mol Neurobiol, June 2015. Lunardi N, Oklopcic A, Prillaman M, Erisir A, Jevtovic-Todorovic V. Abstract  Exposure to general anesthesia (GA) during critical stages of brain development induces widespread neuronal apoptosis and causes long-lasting behavioral deficits in...

Surgical Anesthesia in Young Children Linked to Effects on IQ, Brain Structure

by SmartTots | Jun 8, 2015 | Research Articles

CINCINNATI – Children who received general anesthesia for surgery before age 4 had diminished language comprehension, lower IQ and decreased gray matter density in posterior regions of their brain, according to a new study in the journal Pediatrics. Researchers from...

Long-term NMDA receptor inhibition affects NMDA receptor expression and alters glutamatergic activity in developing rat hippocampal neurons

by SmartTots | Jun 7, 2015 | Research Articles

Toxicology, June 2015.  Sinner B, Friedrich O, Lindner R, Bundscherer A, Graf BM  Abstract  Ketamine and its stereoisomer S(+)-ketamine are widely used for sedation in pediatric anesthesia and intensive care medicine. Numerous experimental studies indicate that...

Safe Anesthesia For Every Tot – The SAFETOTS initiative

by SmartTots | Jun 2, 2015 | Research Articles

Curr Opin Anaesthesiol, June 2015.  Weiss M, Vutskits L, Hansen TG, Engelhardt T   Abstract  PURPOSE OF REVIEW: The term ‘safe use of anesthesia in children is ill-defined and requires definition of and focus on the ‘safe conduct of pediatric...
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Recent Posts

  • A Scoping Review of the Mechanisms Underlying Developmental Anesthetic Neurotoxicity
  • 2025 Annual Meeting, presented by the International Anesthesia Research Society (IARS) and the Society of Critical Care Anesthesiologists (SOCCA), March 20 – 23, 2025, Honolulu, HI
  • Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses: A Natural Experiment Using Appendectomy
  • Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN): a multicentre, open-label, randomised controlled phase 4 trial. Claire Elizabeth Wainwright, et al. June 2024
  • Columbia University Physician Scientist and SmartTots Investigator, Caleb Ing, MD, publishes new findings regarding prenatal exposure to general anesthesia and subsequent risk to the child.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

Tax Information

SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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