by SmartTots | Jan 10, 2021 | Research Articles
Abstract Background Recently, there has been significant focus on the effects of anesthesia on the developing brain. Concern is heightened in children 3 hours. Methods We analyzed all cases of hypospadias repair from December 2011 through December 2018 at Texas...
by SmartTots | Jan 10, 2021 | Research Articles
Abstract For decades, the neurotoxicity caused by anesthetics in mammalian brain development has gained increasing attention. Exposure to anesthetics leads to neurotoxicity and apoptosis of nerve cells, which in turn induces cognitive dysfunction. Although most of the...
by SmartTots | Jan 10, 2021 | Research Articles
Abstract Background The potential adverse effects of exposures to general anesthesia on the developing human brain remain controversial. It has been hypothesized that hypotension accompanying anesthesia could be contributory. We hypothesized that among children...
by SmartTots | Jan 10, 2021 | Research Articles
Abstract Preclinical investigations in animal models have consistently demonstrated neurobiological changes and life-long cognitive deficits following exposure to widely used anesthetics early in life. However, the mechanisms by which these exposures affect brain...
by SmartTots | Dec 22, 2020 | Research Articles
General anesthesia induces changes in dendritic spine number and synaptic transmission in developing mice. These changes are rather disturbing, as similar changes are seen in animal models of neurodevelopmental disorders. We previously suggested that mTor-dependent...
