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Additives to local anesthetics for peripheral nerve blocks or local anesthesia: a review of the literature

by SmartTots | Mar 4, 2015 | Research Articles

Pain Manag, March 2015. Opperer M, Gerner P, Memtsoudis SG   Abstract SUMMARY  A multitude of studies have focused on individual additives to local anesthetics and their effect on quality, onset, duration, spread and selectivity, as well as the potential toxic effects...

Repeated Exposure to Ketamine-Xylazine during Early Development Impairs Motor Learning-dependent Dendritic Spine Plasticity in Adulthood

by SmartTots | Mar 3, 2015 | Research Articles

Anesthesiology, 2015. Huang L, Yang G Abstract BACKGROUND: Recent studies in rodents suggest that repeated and prolonged anesthetic exposure at early stages of development leads to cognitive and behavioral impairments later in life. However, the underlying mechanism...

Effect of apoptosis in neural stem cells treated with sevoflurane

by SmartTots | Mar 3, 2015 | Research Articles

BioMed Central Anesthesiology, 2015. Qiu J, Shi P, Mao W, Zhao Y, Liu W, Wang Y Abstract BACKGROUND: At present, sevoflurane inhalation anesthesia used on infants is well-known. But long-time exposure to inhalation anesthetic could cause neurologic disorder,...

Interventional Procedures for Chronic Pain in Children and Adolescents: A Review of the Current Evidence

by SmartTots | Mar 1, 2015 | Research Articles

Pain Pract, March 2015. Shah RD, Cappiello D, Suresh S   Abstract  This review discusses the role of interventional procedures in the treatment of chronic pain in children and adolescents. Due to lack of scientific evidence, significant controversy surrounds the...

Anesthetic-Related Neurotoxicity in Children – ASA Works in Close Cooperation With FDA and Others to Advance Research

by SmartTots | Mar 1, 2015 | News

SmartTots and FDA American Society of Anesthesiologists Article March 1, 2015 Volume 79, Number 3 Anesthetic-Related Neurotoxicity in Children – ASA Works in Close Cooperation With FDA and Others to Advance Research Randall P. Flick, M.D., M.P.H., Chair Committee on...
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Recent Posts

  • A Scoping Review of the Mechanisms Underlying Developmental Anesthetic Neurotoxicity
  • 2025 Annual Meeting, presented by the International Anesthesia Research Society (IARS) and the Society of Critical Care Anesthesiologists (SOCCA), March 20 – 23, 2025, Honolulu, HI
  • Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses: A Natural Experiment Using Appendectomy
  • Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN): a multicentre, open-label, randomised controlled phase 4 trial. Claire Elizabeth Wainwright, et al. June 2024
  • Columbia University Physician Scientist and SmartTots Investigator, Caleb Ing, MD, publishes new findings regarding prenatal exposure to general anesthesia and subsequent risk to the child.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

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SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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