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Neuroprotective effects of pterostilbene against isoflurane-induced apoptosis through regulating the JNK and PI3K/Akt pathway in neonatal rats

by SmartTots | Mar 1, 2015 | Research Articles

Bangladesh Journal of Pharmacology, 2015. Liu TD, Yang K, Li FK Abstract Increasing numbers of children undergo surgery and are exposed to anesthesia that raises concerns regarding the safety of frequently employed anesthetics. Isoflurane, often used in pediatric...

Researchers Warn on Anesthesia, Unsure of Risk to Children

by SmartTots | Feb 25, 2015 | Research Articles

The New York Times, FEB. 25, 2015 Faced with mounting evidence that general anesthesia may impair brain development in babies and young children, experts said Wednesday that more research is greatly needed and that when planning surgery for a child, parents and...

Is There Evidence for Long-Term Neurocognitive Effects of Sedatives

by SmartTots | Feb 24, 2015 | Research Articles

Pediatric Sedation Outside of the Operating Room: A Multispecialty International Collaboration, 2015. Soriano SG, Vutskits L Abstract The potential neurotoxic effects of drugs used for anesthesia and sedation have captured the attention of pediatric care providers. As...

Dexamethasone but not the equivalent doses of hydrocortisone induces neurotoxicity in neonatal rat brain.

by SmartTots | Feb 24, 2015 | Research Articles

Pediatr Res, February 2015. Feng Y, Kumar P, Wang J, Bhatt AJ Abstract Background: The use of dexamethasone (Dex) in premature infants to treat or prevent chronic lung disease adversely affects neurodevelopment. Recent clinical studies suggest that hydrocortisone (HC)...

Anesthetic neurotoxicity–clinical implications of animal models

by SmartTots | Feb 24, 2015 | Research Articles

N Engl J Med, February 2015. Rappaport BA, Suresh S, Hertz S, Evers AS, Orser BA Abstract Some anesthetics and sedatives have been shown to cause neurotoxic effects in laboratory animals. The FDA collaboration SmartTots recommends undertaking large-scale clinical...
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Recent Posts

  • A Scoping Review of the Mechanisms Underlying Developmental Anesthetic Neurotoxicity
  • 2025 Annual Meeting, presented by the International Anesthesia Research Society (IARS) and the Society of Critical Care Anesthesiologists (SOCCA), March 20 – 23, 2025, Honolulu, HI
  • Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses: A Natural Experiment Using Appendectomy
  • Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN): a multicentre, open-label, randomised controlled phase 4 trial. Claire Elizabeth Wainwright, et al. June 2024
  • Columbia University Physician Scientist and SmartTots Investigator, Caleb Ing, MD, publishes new findings regarding prenatal exposure to general anesthesia and subsequent risk to the child.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

Phone: 415-296-6905
Fax: 415-296-6901

E-mail: smarttots@iars.org

Tax Information

SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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