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Altered Metabolomic Profiles May Be Associated with Sevoflurane-Induced Neurotoxicity in Neonatal Rats.

by SmartTots | Feb 17, 2015 | Research Articles

Neurochem Res, February 2015. Liu B, Gu Y, Xiao H, Lei X, Liang W, Zhang J Abstract Experimental studies demonstrate that inhaled anesthetics can cause neurodegeneration and neurobehavioral dysfunctions. Evidence suggests changes in cerebral metabolism following...

Letter to the Editor: Effects of anesthesia and surgery on the developing brain: problem solved?

by SmartTots | Feb 12, 2015 | Research Articles

David O. Warner1 1 Professor of Anesthesiology, Department of Anesthesiology, Mayo Clinic, Rochester; USA Randall P. Flick2 2 Associate Professor of Anesthesiology and Pediatrics, Departments of Anesthesiology and Pediatrics and Adolescent Medicine, Mayo Clinic,...

Neurosurgical conditions and procedures in infancy are associated with mortality and academic performances in adolescence: a nationwide cohort study

by SmartTots | Feb 11, 2015 | Research Articles

Paediatr Anaesth, February 2015. Hansen TG, Pedersen JK, Henneberg SW, Morton NS, Christensen K Abstract BACKGROUND:  Few human cohort studies on anesthesia-related neurotoxicity and the developing brain have focused on and compared specific surgeries and conditions....

Special aspects of pediatric anesthesia in ophthalmic surgery

by SmartTots | Feb 9, 2015 | Research Articles

Ophthalmologe, February 2015. Keilhauer J, Trieschmann U, Böttiger BW   Abstract  In ophthalmic surgery, children are anesthetized for various reasons. The airway needs special attention as children have higher oxygen requirements and brief periods of apnea can result...

Anesthetic neurotoxicity–clinical implications of animal models

by SmartTots | Feb 3, 2015 | Research Articles

N Engl J Med, February 2015. Rappaport BA, Suresh S, Hertz S, Evers AS, Orser BA Abstract Some anesthetics and sedatives have been shown to cause neurotoxic effects in laboratory animals. The FDA collaboration SmartTots recommends undertaking large-scale clinical...
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Recent Posts

  • A Scoping Review of the Mechanisms Underlying Developmental Anesthetic Neurotoxicity
  • 2025 Annual Meeting, presented by the International Anesthesia Research Society (IARS) and the Society of Critical Care Anesthesiologists (SOCCA), March 20 – 23, 2025, Honolulu, HI
  • Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses: A Natural Experiment Using Appendectomy
  • Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN): a multicentre, open-label, randomised controlled phase 4 trial. Claire Elizabeth Wainwright, et al. June 2024
  • Columbia University Physician Scientist and SmartTots Investigator, Caleb Ing, MD, publishes new findings regarding prenatal exposure to general anesthesia and subsequent risk to the child.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

Tax Information

SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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