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Molecular pathways of mitochondrial dysfunctions: Possible cause of cell death in anesthesia-induced developmental neurotoxicity.

by SmartTots | Jan 9, 2015 | Research Articles

Brain Res Bull, January 2015. Li L, Yu Q, Liang W. Abstract The effect of anesthesia on the developing brain has attracted more attention and arguments. This review summarizes various studies on developmental neurotoxicity induced by anesthesia, particularly focuses...

Long-term effects of single or multiple neonatal sevoflurane exposures on rat hippocampal ultrastructure

by SmartTots | Jan 9, 2015 | Research Articles

Anesthesiology, January 2015.  Amrock LG, Starner ML, Murphy KL, Baxter MG   Abstract  BACKGROUND:  Neonatal exposure to general anesthetics may pose significant neurocognitive risk. Human epidemiological studies demonstrate higher rates of learning disability among...

Propofol inhibits proliferation and induces neuroapoptosis of hippocampal neurons in vitro via downregulation of NF-κB p65 and Bcl-2 and upregulation of caspase-3

by SmartTots | Dec 27, 2014 | Research Articles

Cell Biochem Funct, December 2014. Zhong Y, Liang Y, Chen J, Li L, Qin Y, Guan E, He D, Wei Y, Xie Y, Xiao Q Abstract Propofol is widely used in paediatric anaesthesia and intensive care unit because of its essentially short-acting anaesthetic effect. Recent data have...

Neurodevelopment of children exposed to anesthesia: Design of the Mayo Anesthesia Safety in Kids (MASK) study

by SmartTots | Dec 24, 2014 | Research Articles

Contemp Clin Trials, December 2014. Gleich SJ, Flick R, Hu D, Zaccariello MJ, Colligan RC, Katusic SK, Schroeder DR, Hanson A, Buenvenida S, Wilder RT, Sprung J, Voigt RG, Paule MG, Chelonis JJ, Warner DO Abstract There is increasing evidence that exposure of...

Are Caudal Blocks for Pain Control Safe in Children? An Analysis of 18,650 Caudal Blocks from the Pediatric Regional Anesthesia Network (PRAN) Database.

by SmartTots | Dec 21, 2014 | Research Articles

Anesthesia & Analgesia, November 2014. Suresh S, Long J, Birmingham PK, Oliveira GS Jr. Abstract BACKGROUND: The caudal block is the most commonly performed regional anesthesia technique in pediatric patients undergoing surgical procedures, but safety concerns...
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Recent Posts

  • A Scoping Review of the Mechanisms Underlying Developmental Anesthetic Neurotoxicity
  • 2025 Annual Meeting, presented by the International Anesthesia Research Society (IARS) and the Society of Critical Care Anesthesiologists (SOCCA), March 20 – 23, 2025, Honolulu, HI
  • Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses: A Natural Experiment Using Appendectomy
  • Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN): a multicentre, open-label, randomised controlled phase 4 trial. Claire Elizabeth Wainwright, et al. June 2024
  • Columbia University Physician Scientist and SmartTots Investigator, Caleb Ing, MD, publishes new findings regarding prenatal exposure to general anesthesia and subsequent risk to the child.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

Tax Information

SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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