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Anesthesia-related neurotoxicity and the developing animal brain is not a significant problem in children.

by SmartTots | Sep 3, 2014 | Research Articles

Paediatric Anaesthesia, September 2014. Hansen TG Abstract A multitude of animal studies have shown that virtually all general anesthetics used in clinical practice possibly during a vulnerable period of brain development (i.e., brain growth spurt, peak of...

Erythropoietin protects newborn rat against sevoflurane-induced neurotoxicity

by SmartTots | Sep 1, 2014 | Research Articles

Pediatric Anesthesia, July 2014. Pellegrini L, Bennis Y, Velly L, Grandvuillemin I, Pisano P, Bruder N, Guillet B Abstract Introduction: Recent data on newborn animals exposed to anesthetics have raised safety concerns regarding anesthesia practices in young children....

Cognitive Outcomes After Infant Spinal Anesthesia: The Other Side of the Coin

by SmartTots | Sep 1, 2014 | Research Articles

Anesthesia & Analgesia, September 2014. Nemergut ME, Crow S, Flick RP Editorial Summary In their study, Williams et al. sought to isolate the effect of surgery from that of general anesthesia by retrospectively comparing the cognitive outcomes of a cohort of...

Anesthetic Preconditioning Inhibits Isoflurane-Mediated Apoptosis in the Developing Rat Brain.

by SmartTots | Aug 5, 2014 | Research Articles

Anesthesia & Analgesia, Aug. 5, 2014. Peng J, Drobish J, Liang Ge, Wu Z, Liu C, Joseph D, Abdou H, Eckenhoff M, Wei H. Abstract Background: We hypothesized that preconditioning (PC) with a short exposure to isoflurane (ISO) would reduce neurodegeneration induced...

Long term neurotoxicity by general anesthetics in infants

by SmartTots | Aug 3, 2014 | Research Articles

Anaesthesia, Pain & Intensive Care, 2014. Rudrashish Haldar, Sukhminder Jit Singh Bajwa. Abstract Development of neurotoxicity in infants and children who had been exposed to general anesthetics has garnered attention in recent times and sparked vigorous debates....
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Recent Posts

  • A Scoping Review of the Mechanisms Underlying Developmental Anesthetic Neurotoxicity
  • 2025 Annual Meeting, presented by the International Anesthesia Research Society (IARS) and the Society of Critical Care Anesthesiologists (SOCCA), March 20 – 23, 2025, Honolulu, HI
  • Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses: A Natural Experiment Using Appendectomy
  • Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN): a multicentre, open-label, randomised controlled phase 4 trial. Claire Elizabeth Wainwright, et al. June 2024
  • Columbia University Physician Scientist and SmartTots Investigator, Caleb Ing, MD, publishes new findings regarding prenatal exposure to general anesthesia and subsequent risk to the child.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

Tax Information

SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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