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Inhibition of Acetylcholinesterase Modulates NMDA Receptor Antagonist Mediated Alterations in the Developing Brain

by SmartTots | Mar 13, 2014 | Research Articles

Int. J. Mol. Sci., March 3, 2014. Bendix I, Serdar M, Herz J, von Haefen C, Nasser F, Rohrer B, Endesfelder S, Felderhoff-Mueser U, Spies CD, Sifringer M Abstract Exposure to N-methyl-d-aspartate (NMDA) receptor antagonists has been demonstrated to induce...

Physiological disturbance may contribute to neurodegeneration induced by isoflurane or sevoflurane in 14 day old rats

by SmartTots | Mar 10, 2014 | Research Articles

Med Gas Res, March 2014. Zhang L, Zhang J, Dong Y, Swain CA, Zhang Y, Xie Z. Abstract BACKGROUND: Anesthesia with multiple exposures of commonly used inhalation anesthetic sevoflurane induces neuroinflammation and cognitive impairment in young mice, but anesthesia...

The potential dual effects of sevoflurane on AKT/GSK3beta signaling pathway

by SmartTots | Mar 10, 2014 | Research Articles

Med Gas Res, March 2014. Zhang L, Zhang J, Dong Y, Swain CA, Zhang Y, Xie Z. Abstract BACKGROUND: Anesthesia with multiple exposures of commonly used inhalation anesthetic sevoflurane induces neuroinflammation and cognitive impairment in young mice, but anesthesia...

Isoflurane-induced Apoptosis of Neurons and Oligodendrocytes in the Fetal Rhesus Macaque Brain

by SmartTots | Mar 10, 2014 | Research Articles

Anesthesiology, March 2014. Creeley CE, Dikranian KT, Dissen GA, Back SA, Olney JW, Brambrink AM. Abstract Background: The authors have previously shown that exposure of the neonatal nonhuman primate (NHP) brain to isoflurane for 5 h causes widespread acute apoptotic...

Neonatal Morphine in Extremely and Very Preterm Neonates: Its Effect on the Developing Brain, a Review

by SmartTots | Mar 10, 2014 | Research Articles

J Matern Fetal Neonatal Med, March 2014. Schuurmans J, Benders M, Lemmers P, van Bel F. Abstract Objective: Preterm infants requiring intensive care experience a large number of stressful and painful procedures. Management of stress and pain is therefore an important...
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Recent Posts

  • A Scoping Review of the Mechanisms Underlying Developmental Anesthetic Neurotoxicity
  • 2025 Annual Meeting, presented by the International Anesthesia Research Society (IARS) and the Society of Critical Care Anesthesiologists (SOCCA), March 20 – 23, 2025, Honolulu, HI
  • Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses: A Natural Experiment Using Appendectomy
  • Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN): a multicentre, open-label, randomised controlled phase 4 trial. Claire Elizabeth Wainwright, et al. June 2024
  • Columbia University Physician Scientist and SmartTots Investigator, Caleb Ing, MD, publishes new findings regarding prenatal exposure to general anesthesia and subsequent risk to the child.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

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SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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