SmartTots
  • Home
  • About
    • Who We Are
    • FAQ
  • News
    • Newsletter Archive
  • Resources
    • Healthcare Professionals Resources
    • Advice for Parents and Caregivers
    • Clinical Research Articles
    • Preclinical Research Articles
    • Live Stream
    • Newsletter Archive
    • Presentation Videos
    • Research and Grants
    • FDA Drug Safety Communication
  • Donor Recognition
  • Contact
Select Page

Inhibition of aberrant cyclin-dependent kinase 5 activity attenuates isoflurane neurotoxicity in the developing brain

by SmartTots | Feb 17, 2014 | Research Articles

Neuropharmacology, February 2014. Wang WY, Luo Y, Jia LJ, Hu SF, Lou XK, Shen SL, Lu H, Zhang HH, Yang R, Wang H, Ma ZW, Xue QS, Yu BW. Abstract Aberrant CDK5 activity is implicated in a number of neurodegenerative disorders. Isoflurane exposure leads to neuronal...

Anesthesia and the Developing Brain: Relevance to the Pediatric Cardiac Surgery

by SmartTots | Feb 10, 2014 | Research Articles

Brain Sci, February 2014. Wise-Faberowski L, Quinonez ZA, Hammer GB. Abstract Anesthetic neurotoxicity has been a hot topic in anesthesia for the past decade. It is of special interest to pediatric anesthesiologists. A subgroup of children potentially at greater risk...

Adverse effect of inhalational anesthetics on the developing brain

by SmartTots | Feb 4, 2014 | Research Articles

Med Gas Res, February 2014. Wang M, Zhang JH, Applegate RL 2nd. Abstract We did a PubMed search and summarized studies on the potential adverse effect of anesthetics especially neurotoxicity in the developing brain, so named anesthesia-induced developmental...

Brain regional vulnerability to anaesthesia-induced neuroapoptosis shifts with age at exposure and extends into adulthood for some regions

by SmartTots | Jan 24, 2014 | Research Articles

Br. J. Anaesth, January 2014. Deng M, Hofacer R, Jiang C, Joseph B, Hughes E, Jia B, Danzer S, Loepke A. Abstract Background: General anaesthesia facilitates surgical operations and painful interventions in millions of patients every year. Recent observations of...

Physiological disturbance may contribute to neurodegeneration induced by isoflurane or sevoflurane in 14 day old rats

by SmartTots | Jan 10, 2014 | Research Articles

PLoS One, January 2014. Wu B, Yu Z, You S, Zheng Y, Liu J, Gao Y, Lin H, Lian Q Abstract BACKGROUND: Volatile anesthetics are widely used in pediatric anesthesia but their potential neurotoxicity raise significant concerns regarding sequelae after anesthesia. However,...
« Older Entries
Next Entries »

Categories

  • Clinical Articles
  • Events
  • News
  • Preclinical Articles
  • Research Articles

Recent Posts

  • A Scoping Review of the Mechanisms Underlying Developmental Anesthetic Neurotoxicity
  • 2025 Annual Meeting, presented by the International Anesthesia Research Society (IARS) and the Society of Critical Care Anesthesiologists (SOCCA), March 20 – 23, 2025, Honolulu, HI
  • Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses: A Natural Experiment Using Appendectomy
  • Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN): a multicentre, open-label, randomised controlled phase 4 trial. Claire Elizabeth Wainwright, et al. June 2024
  • Columbia University Physician Scientist and SmartTots Investigator, Caleb Ing, MD, publishes new findings regarding prenatal exposure to general anesthesia and subsequent risk to the child.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

Tax Information

SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

GuideStar/Candid

Guidestar

View our Summary

  • Privacy Policy
  • Terms of Use
  • International Anesthesia Research Society
  • X

Designed by Elegant Themes | Powered by WordPress