SmartTots
  • Home
  • About
    • Who We Are
    • FAQ
  • News
    • Newsletter Archive
  • Resources
    • Healthcare Professionals Resources
    • Advice for Parents and Caregivers
    • Clinical Research Articles
    • Preclinical Research Articles
    • Live Stream
    • Newsletter Archive
    • Presentation Videos
    • Research and Grants
    • FDA Drug Safety Communication
  • Donor Recognition
  • Contact
Select Page

Subclinical Carbon Monoxide Limits Apoptosis in the Developing Brain After Isoflurane Exposure

by SmartTots | Jan 10, 2014 | Research Articles

Anesth Analg, January 2014. Cheng Y, Levy RJ. Abstract Background: Volatile anesthetics cause widespread apoptosis in the developing brain. Carbon monoxide (CO) has antiapoptotic properties, and exhaled endogenous CO is commonly rebreathed during low-flow anesthesia...

SmartTots is proud to endorse the EuroSTAR – SmartTots Scientific Network Meeting on Pediatric Anesthesia

by SmartTots | Jan 10, 2014 | Research Articles

San Francisco CA (January 10, 2014) – SmartTots is proud to endorse the EuroSTAR – SmartTots Scientific Network Meeting on Pediatric Anesthesia and Neurotoxicity From the GAS Study to future collaborative trials, taking place in Genoa, Italy on May 23-24,...

Brain regional vulnerability to anaesthesia-induced neuroapoptosis shifts with age at exposure and extends into adulthood for some regions

by SmartTots | Jan 3, 2014 | Research Articles

Br. J. Anaesth, January 2014. Deng M, Hofacer R, Jiang C, Joseph B, Hughes E, Jia B, Danzer S, Loepke A. Abstract Background: General anaesthesia facilitates surgical operations and painful interventions in millions of patients every year. Recent observations of...

Modeling anesthetic developmental neurotoxicity using human stem cells

by SmartTots | Dec 26, 2013 | Research Articles

Semin Cardiothorac Vasc Anesth, December 2013. Bai X, Twaroski D, Bosnjak ZJ. Abstract Mounting preclinical evidence in rodents and nonhuman primates has demonstrated that prolonged exposure of developing animals to general anesthetics can induce widespread neuronal...

Perioperative Central Nervous System Injury in Neonates

by SmartTots | Dec 11, 2013 | Research Articles

British Journal of Anaesthesia. 2012 Dec;109 Suppl 1. McCann ME, Soriano SG. Abstract Anaesthetic-induced developmental neurotoxicity (AIDN) has been clearly established in laboratory animal models. The possibility of neurotoxicity during uneventful anaesthetic...
« Older Entries
Next Entries »

Categories

  • Clinical Articles
  • Events
  • News
  • Preclinical Articles
  • Research Articles

Recent Posts

  • A Scoping Review of the Mechanisms Underlying Developmental Anesthetic Neurotoxicity
  • 2025 Annual Meeting, presented by the International Anesthesia Research Society (IARS) and the Society of Critical Care Anesthesiologists (SOCCA), March 20 – 23, 2025, Honolulu, HI
  • Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses: A Natural Experiment Using Appendectomy
  • Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN): a multicentre, open-label, randomised controlled phase 4 trial. Claire Elizabeth Wainwright, et al. June 2024
  • Columbia University Physician Scientist and SmartTots Investigator, Caleb Ing, MD, publishes new findings regarding prenatal exposure to general anesthesia and subsequent risk to the child.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

Tax Information

SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

GuideStar/Candid

Guidestar

View our Summary

  • Privacy Policy
  • Terms of Use
  • International Anesthesia Research Society
  • X

Designed by Elegant Themes | Powered by WordPress