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Modeling anesthetic developmental neurotoxicity using human stem cells

by SmartTots | Dec 10, 2013 | Research Articles

Semin Cardiothorac Vasc Anesth, December 2013. Bai X, Twaroski D, Bosnjak ZJ. Abstract Mounting preclinical evidence in rodents and nonhuman primates has demonstrated that prolonged exposure of developing animals to general anesthetics can induce widespread neuronal...

Early life exposure to sevoflurane impairs adulthood spatial memory in the rat

by SmartTots | Dec 10, 2013 | Research Articles

Neurotoxicology, December 2013. Shen X, Liu Y, Xu S, Zhao Q, Guo X, Shen R, Wang F. Abstract Sevoflurane is a general anesthetic commonly used in the pediatric setting because it is sweet-smelling, nonflammable, fast acting and has a very short recovery time. Although...

Anesthesia for the young child undergoing ambulatory procedures: current concerns regarding harm to the developing brain

by SmartTots | Dec 10, 2013 | Research Articles

Curr Opin Anaesthesiol, December 2013. Olsen EA, Brambrink AM Abstract PURPOSE OF REVIEW: Sedation and anesthesia are often necessary for children at any age, and are frequently provided in ambulatory settings. Concerns have mounted, based on both laboratory studies...

Neonatal exposure to sevoflurane causes significant suppression of hippocampal long-term potentiation in postgrowth rats.

by SmartTots | Dec 10, 2013 | Research Articles

Anesth Analg, December 2013. Kato R, Tachibana K, Nishimoto N, Hashimoto T, Uchida Y, Ito R, Tsuruga K, Takita K, Morimoto Y. Abstract Background: The inhaled anesthetic sevoflurane is commonly used for neonates in the clinical setting. Recent studies have indicated...

Do we actually need to anesthetize the neonate?

by SmartTots | Dec 5, 2013 | Research Articles

Pediatric Anesthesia, December 2013. Davidson, Andrew. Abstract In this issue of Pediatric Anesthesia, authors discuss several key aspects of the theory and practice of neonatal anesthesia. Recurring themes are that neonatal physiology is substantially different to...
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Recent Posts

  • A Scoping Review of the Mechanisms Underlying Developmental Anesthetic Neurotoxicity
  • 2025 Annual Meeting, presented by the International Anesthesia Research Society (IARS) and the Society of Critical Care Anesthesiologists (SOCCA), March 20 – 23, 2025, Honolulu, HI
  • Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses: A Natural Experiment Using Appendectomy
  • Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN): a multicentre, open-label, randomised controlled phase 4 trial. Claire Elizabeth Wainwright, et al. June 2024
  • Columbia University Physician Scientist and SmartTots Investigator, Caleb Ing, MD, publishes new findings regarding prenatal exposure to general anesthesia and subsequent risk to the child.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

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SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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