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Dr. Alastair Wood and Holger Liepmann To Champion SmartTots

by SmartTots | Jun 27, 2013 | Research Articles

Dr. Michael Roizen, Chair of the SmartTots Executive Board announced the addition of two executive board members, Alastair J.J. Wood, M.B. Ch.B. FRCP FACP and Holger Liepmann. SmartTots funds research with the goal of making surgery safer for the millions of infants...

Neurotoxicity of Anesthetics in the Developing Brain: Summary Points (Last revised: October 1, 2012)

by SmartTots | Jun 23, 2013 | News

1. The major excitatory neurotransmitter, glutamate, and the major inhibitory neurotransmitter, gamma-aminobutyric acid (GABA), are generally associated with neuronal communication in the adult brain.(1)   2. In the developing brain, these transmitters play a...

Myron Yaster, MD Speaks to Pediatric Anesthesia (PodCast)

by SmartTots | Jun 12, 2013 | News

Myron Yaster, MD Speaks to Pediatric Anesthesia (PodCast)      

Cell age-specific vulnerability of neurons to anesthetic toxicity

by SmartTots | Jun 3, 2013 | Research Articles

Department of Anesthesiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH; Program in Neuroscience, University of Cincinnati, Cincinnati, OH, June 2013. Hofacer RD, Deng M, Ward CG, Joseph B, Hughes EA, Jiang C, Danzer SC, Loepke AW Abstract...

Neuroprotective effects of dexmedetomidine against glutamate agonist-induced neuronal cell death are related to increased astrocyte brain-derived neurotrophic factor expression.

by SmartTots | Jun 1, 2013 | Research Articles

Abstract BACKGROUND: Brain-derived neurotrophic factor (BDNF) plays a prominent role in neuroprotection against perinatal brain injury. Dexmedetomidine, a selective agonist of α2-adrenergic receptors, also provides neuroprotection against glutamate-induced damage....
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Recent Posts

  • A Scoping Review of the Mechanisms Underlying Developmental Anesthetic Neurotoxicity
  • 2025 Annual Meeting, presented by the International Anesthesia Research Society (IARS) and the Society of Critical Care Anesthesiologists (SOCCA), March 20 – 23, 2025, Honolulu, HI
  • Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses: A Natural Experiment Using Appendectomy
  • Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN): a multicentre, open-label, randomised controlled phase 4 trial. Claire Elizabeth Wainwright, et al. June 2024
  • Columbia University Physician Scientist and SmartTots Investigator, Caleb Ing, MD, publishes new findings regarding prenatal exposure to general anesthesia and subsequent risk to the child.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

Tax Information

SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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