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Prognostic Study of Sevoflurane-Based General Anesthesia on Cognitive Function in Children

by SmartTots | Feb 3, 2013 | Research Articles

J Anesth. 2013 Feb 6. [Epub ahead of print] Abstract PURPOSE: It is unclear whether volatile general anesthetics have sustained adverse effects on the immature brains of children. We performed a self-controlled study to evaluate the effects of strabismus surgery under...

Anesthetics Interfere with Axon Guidance in Developing Mouse Neocortical Neurons In Vitro via a γ-Aminobutyric Acid Type A Receptor Mechanism

by SmartTots | Jan 29, 2013 | Research Articles

Mintz, C. David M.D., Ph.D.; Barrett, Kendall M. S.; Smith, Sarah C. M.D.; Benson, Deanna L. Ph.D.; Harrison, Neil L. Ph.D. Anesthesiology. 2013 Jan 29. [Epub ahead of print] Abstract Background: The finding that exposure to general anesthetics (GAs) in childhood may...

Dual Effects of Isoflurane on Proliferation, Differentiation, and Survival in Human Neuroprogenitor Cells

by SmartTots | Jan 11, 2013 | Research Articles

Zhao, Xuli; Yang, Zeyong; Liang, Ge; Wu, Zhen; Peng, Yi; Joseph, Donald J.; Inan, Saadet; Wei, Huafeng Anesthesiology. 2013 Jan 11. [Epub ahead of print] Abstract Background: Previous studies have demonstrated that isoflurane can provide both neuroprotection and...

Early Developmental Exposure to Volatile Anesthetics Causes Behavioral Defects in Caenorhabditis elegans

by SmartTots | Jan 11, 2013 | Research Articles

Caenorhabditis elegans Anesthesia & Analgesia. January 2013, 116 (1). Katherine R. Gentry, MD, Louise M. Steele, PhD, Margaret M. Sedensky, MD and Philip G. Morgan, MD. Abstract BACKGROUND: Mounting evidence from animal studies shows that anesthetic exposure in...

Selective Anesthesia-induced Neuroinflammation in Developing Mouse Brain and Cognitive Impairment

by SmartTots | Jan 9, 2013 | Research Articles

Shen, Xia M.D., Ph.D.; Dong, Yuanlin M.D., M.S.; Xu, Zhipeng M.D., Ph.D.; Wang, Hui M.D., Ph.D.; Miao, Changhong M.D., Ph.D.; Soriano, Sulpicio G. M.D.; Sun, Dandan M.D., Ph.D.; Baxter, Mark G. Ph.D.; Zhang, Yiying M.D., M.S.; Xie, Zhongcong M.D., Ph.D....
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Recent Posts

  • A Scoping Review of the Mechanisms Underlying Developmental Anesthetic Neurotoxicity
  • 2025 Annual Meeting, presented by the International Anesthesia Research Society (IARS) and the Society of Critical Care Anesthesiologists (SOCCA), March 20 – 23, 2025, Honolulu, HI
  • Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses: A Natural Experiment Using Appendectomy
  • Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN): a multicentre, open-label, randomised controlled phase 4 trial. Claire Elizabeth Wainwright, et al. June 2024
  • Columbia University Physician Scientist and SmartTots Investigator, Caleb Ing, MD, publishes new findings regarding prenatal exposure to general anesthesia and subsequent risk to the child.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

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SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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