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Anesthetics interfere with the polarization of developing cortical neurons

by SmartTots | Oct 24, 2012 | Research Articles

J Neurosurg Anesthesiol. 2012 Oct;24(4):368-75. PMID:23085784 Mintz CD, Smith SC, Barrett KM, Benson DL Abstract Numerous studies from the clinical and preclinical literature indicate that general anesthetic agents have toxic effects on the developing brain, but the...

Preclinical research into the effects of anesthetics on the developing brain: promises and pitfalls

by SmartTots | Oct 24, 2012 | Research Articles

J Neurosurg Anesthesiol. 2012 Oct;24(4):362-7 Mintz CD, Wagner M, Loepke AW Abstract Every year millions of children are treated with anesthetics and sedatives to alleviate pain and distress during invasive procedures. Accumulating evidence suggests the possibility...

Pediatric anesthesia and neurodevelopmental impairments: a Bayesian meta-analysis

by SmartTots | Oct 24, 2012 | Research Articles

J Neurosurg Anesthesiol. 2012 Oct;24(4):376-81. DiMaggio C, Sun LS, Ing C, Li G. Abstract Experimental evidence of anesthesia-induced neurotoxicity has caused serious concern about the long-term effect of commonly used volatile anesthetic agents on young children....

Elective procedures and anesthesia in children: pediatric surgeons enter the dialogue on neurotoxicity questions, surgical options, and parental concerns

by SmartTots | Oct 24, 2012 | Research Articles

J Neurosurg Anesthesiol. 2012 Oct;24(4):396-400. Byrne MW, Ascherman JA, Casale P, Cowles RA, Gallin PF, Maxwell LG. Abstract The Pediatric Anesthesia NeuroDevelopment Assessment research group at Columbia University Medical Center Department of Anesthesiology has...

Feasibility and pilot study of the Pediatric Anesthesia NeuroDevelopment Assessment (PANDA) project

by SmartTots | Oct 24, 2012 | Research Articles

J Neurosurg Anesthesiol. 2012 Oct;24(4):382-8. Sun LS, Li G, DiMaggio CJ, Byrne MW, Ing C, Miller TL, Bellinger DC, Han S, McGowan FX. Abstract BACKGROUND: Animal studies have documented that exposure of the developing brain to commonly used anesthetic agents induces...
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Recent Posts

  • A Scoping Review of the Mechanisms Underlying Developmental Anesthetic Neurotoxicity
  • 2025 Annual Meeting, presented by the International Anesthesia Research Society (IARS) and the Society of Critical Care Anesthesiologists (SOCCA), March 20 – 23, 2025, Honolulu, HI
  • Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses: A Natural Experiment Using Appendectomy
  • Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN): a multicentre, open-label, randomised controlled phase 4 trial. Claire Elizabeth Wainwright, et al. June 2024
  • Columbia University Physician Scientist and SmartTots Investigator, Caleb Ing, MD, publishes new findings regarding prenatal exposure to general anesthesia and subsequent risk to the child.

About SmartTots

The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year.

Contact SmartTots

Phone: 415-296-6905
Fax: 415-296-6901

E-mail: [email protected]

Tax Information

SmartTots is a research initiative of the IARS, a 501 c (3) non-profit organization.

Federal Tax ID 34-0750348

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