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Anesthetic activation of GABA_A receptors in astrocytes trigger a persistent increase in cell-surface expression of α5GABA_A receptors in neurons via IL-1β in mice

by SmartTots | May 23, 2021 | Research Articles

Arsène Pinguelo, Ph.D. candidate University of Toronto Using cortical astrocytes and hippocampal neurons from fetal mice, investigators explore mechanisms that raise inhibitory tonic current (surface expression) linked to post-anesthetic cognitive deficits generated...

Behavioural impairments after exposure of neonatal mice to propofol are accompanied by reductions in neuronal activity in cortical circuitry.

by SmartTots | May 1, 2021 | Research Articles

Abstract Background Both animal and retrospective human studies have linked extended and repeated general anaesthesia during early development with cognitive and behavioural deficits later in life. However, the neuronal circuit mechanisms underlying this...

Protective Effect of GM1 Attenuates Hippocampus and Cortex Apoptosis After Ketamine Exposure in Neonatal Rat via PI3K/AKT/GSK3β Pathway.

by SmartTots | May 1, 2021 | Research Articles

Abstract Ketamine is a widely used analgesic and anesthetic in obstetrics and pediatrics. Ketamine is known to promote neuronal death and cognitive dysfunction in the brains of humans and animals during development. Monosialotetrahexosyl ganglioside (GM1), a promoter...

Singular and short-term anesthesia exposure in the developing brain induces persistent neuronal changes consistent with chronic neurodegenerative disease.

by SmartTots | May 1, 2021 | Research Articles

Abstract The potential adverse impact of inhalational anesthetics on the developing brain was highlighted by the addition of a medication warning by the U.S. Food and Drug Administration for their use in the pediatric population. To investigate mechanisms by which...

Edaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway.

by SmartTots | May 1, 2021 | Research Articles

Abstract Background To investigate the neuroprotective effect of edaravone on excessive-dose propofol-induced neurotoxicity in the hippocampus of newborn rats and HT22 cells. Methods Cell proliferation was investigated by assessing ki67 expression in the neural stem...

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Anesthetic activation of GABA_A receptors in astrocytes trigger a persistent increase in cell-surface expression of α5GABA_A receptors in neurons via IL-1β in mice

Behavioural impairments after exposure of neonatal mice to propofol are accompanied by reductions in neuronal activity in cortical circuitry.

Protective Effect of GM1 Attenuates Hippocampus and Cortex Apoptosis After Ketamine Exposure in Neonatal Rat via PI3K/AKT/GSK3β Pathway.

Singular and short-term anesthesia exposure in the developing brain induces persistent neuronal changes consistent with chronic neurodegenerative disease.

Edaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway.

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Anesthetic activation of GABAA receptors in astrocytes trigger a persistent increase in cell-surface expression of α5GABAA receptors in neurons via IL-1β in mice

Behavioural impairments after exposure of neonatal mice to propofol are accompanied by reductions in neuronal activity in cortical circuitry.

Protective Effect of GM1 Attenuates Hippocampus and Cortex Apoptosis After Ketamine Exposure in Neonatal Rat via PI3K/AKT/GSK3β Pathway.

Singular and short-term anesthesia exposure in the developing brain induces persistent neuronal changes consistent with chronic neurodegenerative disease.

Edaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway.

Categories

Recent Posts

Anesthetic activation of GABA_A receptors in astrocytes trigger a persistent increase in cell-surface expression of α5GABA_A receptors in neurons via IL-1β in mice