by SmartTots | May 1, 2021 | Research Articles
Abstract Background Structural brain abnormalities in newborn animals after prolonged exposure to all routinely used general anaesthetics have raised substantial concerns for similar effects occurring in millions of children undergoing surgeries annually. Combining a...
by SmartTots | May 1, 2021 | Research Articles
Abstract Anesthetic-induced toxicity in early life may lead to risk of cognitive decline at later ages. Notably, multiple exposures to isoflurane (ISO) cause acute apoptotic cell death in the developing brain and long-term cognitive dysfunction. This study is the...
by SmartTots | May 1, 2021 | Research Articles
Abstract Developing brain networks are particularly receptive to acquiring certain kinds of information and even need those instructive signals for their continued functional assembly. Information input is commonly translated into neural activity driven primarily by...
by SmartTots | May 1, 2021 | Research Articles
Abstract Objective Common inhalation anesthetics used for clinical anesthesia (such as sevoflurane) may induce nerve cell apoptosis during central nervous system development. Furthermore, anesthetics can produce cognitive impairments, such as learning and memory...
by SmartTots | May 1, 2021 | Research Articles
Abstract The aim of the present study was to investigate the effect of exposure to sevoflurane general anesthesia during early pregnancy on interferon-inducible protein AIM2 (AIM2) expression in the hippocampus and parietal cortex of the offspring Sprague-Dawley (SD)...
